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Index > Protein center > ABCB9(Gene name) > Human
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  • ABCB9 (Gene name),
  • ATP-binding cassette sub-family B member 9 (Protein name ),  ABCB9_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ABCB9(KIAA1520);
    Protein name:
    ATP-binding cassette sub-family B member 9;
    Alternative:
    TAP-like protein(TAPL);ATP-binding cassette transporter 9(ABC transporter 9 protein;hABCB9);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored.
    Subcellular Location:
    Lysosome membrane Multi-pass membrane protein May be located in membrane rafts.
    Protein Attributes:
    Sequence length:
    766
    Sequence:
    50:
    MRLWKAVVVT | LAFMSVDICV | TTAIYVFSHL | DRSLLEDIRH | FNIFDSVLDL | 
    100:
    WAACLYRSCL | LLGATIGVAK | NSALGPRRLR | ASWLVITLVC | LFVGIYAMVK | 
    150:
    LLLFSEVRRP | IRDPWFWALF | VWTYISLGAS | FLLWWLLSTV | RPGTQALEPG | 
    200:
    AATEAEGFPG | SGRPPPEQAS | GATLQKLLSY | TKPDVAFLVA | ASFFLIVAAL | 
    250:
    GETFLPYYTG | RAIDGIVIQK | SMDQFSTAVV | IVCLLAIGSS | FAAGIRGGIF | 
    300:
    TLIFARLNIR | LRNCLFRSLV | SQETSFFDEN | RTGDLISRLT | SDTTMVSDLV | 
    350:
    SQNINVFLRN | TVKVTGVVVF | MFSLSWQLSL | VTFMGFPIIM | MVSNIYGKYY | 
    400:
    KRLSKEVQNA | LARASNTAEE | TISAMKTVRS | FANEEEEAEV | YLRKLQQVYK | 
    450:
    LNRKEAAAYM | YYVWGSGLTL | LVVQVSILYY | GGHLVISGQM | TSGNLIAFII | 
    500:
    YEFVLGDCME | SVGSVYSGLM | QGVGAAEKVF | EFIDRQPTMV | HDGSLAPDHL | 
    550:
    EGRVDFENVT | FTYRTRPHTQ | VLQNVSFSLS | PGKVTALVGP | SGSGKSSCVN | 
    600:
    ILENFYPLEG | GRVLLDGKPI | SAYDHKYLHR | VISLVSQEPV | LFARSITDNI | 
    650:
    SYGLPTVPFE | MVVEAAQKAN | AHGFIMELQD | GYSTETGEKG | AQLSGGQKQR | 
    700:
    VAMARALVRN | PPVLILDEAT | SALDAESEYL | IQQAIHGNLQ | KHTVLIIAHR | 
    750:
    LSTVEHAHLI | VVLDKGRVVQ | QGTHQQLLAQ | GGLYAKLVQR | QMLGLQPAAD | 
    766:
    FTAGHNEPVA | NGSHKA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    MIM:
    Pfam:
    SMR:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human ATP-binding cassette sub-family B member 9
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    ELISA Kit for Human ATP-binding cassette sub-family B member 9
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    ELISA Kit for Human ATP-binding cassette sub-family B member 9
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    Packing:
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    CLIA Kit for Human ATP-binding cassette sub-family B member 9
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    Packing:
    96T
    CLIA Kit for Human ATP-binding cassette sub-family B member 9
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    U1181r
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    Packing:
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    CLIA Kit for Human ATP-binding cassette sub-family B member 9
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    U1181h
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    MSDS:
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    Packing:
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    Polyclonal Antibody for Human ATP-binding cassette sub-family B member 9
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    P1181Rb-h
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    40ug/0.2ml
    Polyclonal Antibody for Human ATP-binding cassette sub-family B member 9
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    P1181Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human ATP-binding cassette sub-family B member 9
    Cat.:
    P1181Rb-m
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human ATP-binding cassette sub-family B member 9
    Monoclonal Antibody for Human ATP-binding cassette sub-family B member 9
    Monoclonal Antibody for Human ATP-binding cassette sub-family B member 9
    Protein for Human ATP-binding cassette sub-family B member 9
    Protein for Human ATP-binding cassette sub-family B member 9
    Protein for Human ATP-binding cassette sub-family B member 9

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "A half-type ABC transporter TAPL is highly conserved between rodent and man, and the human gene is not responsive to interferon-gamma in contrast to TAP1 and TAP2."
      Kobayashi A. , Kasano M. , Maeda T. , Hori S. , Motojima K. , Suzuki M. , Fujiwara T. , Takahashi E. , Yabe T. , Tanaka K. , Kasahara M. , Yamaguchi Y. , Maeda M.
      J. Biochem.128:711-718(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION
      tissue: Embryonic kidney.
    2. 2.
      "Characterization of ABCB9, an ATP binding cassette protein associated with lysosomes."
      Zhang F. , Zhang W. , Liu L. , Fisher C.L. , Hui D. , Childs S. , Dorovini-Zis K. , Ling V.
      J. Biol. Chem.275:23287-23294(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Lymphoblast.
    3. 3.
      "Gene organization of human transporter associated with antigen processing-like (TAPL, ABCB9): analysis of alternative splicing variants and promoter activity."
      Kobayashi A. , Hori S. , Suita N. , Maeda M.
      Biochem. Biophys. Res. Commun.309:815-822(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 4 AND 5)
      tissue: Cervix carcinoma.
      tissue: Embryonic kidney.
    4. 4.
      "Alternative splice variants encoding unstable protein domains exist in the human brain."
      Homma K. , Kikuno R.F. , Nagase T. , Ohara O. , Nishikawa K.
      J. Mol. Biol.343:1207-1220(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Brain.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Kikuno R. , Ishikawa K. , Hirosawa M. , Ohara O.
      DNA Res.7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      Ohara O. , Nagase T. , Kikuno R.
      Submitted (2005-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Trachea.
    8. 8.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    10. 10.
      "Membrane localization of transporter associated with antigen processing (TAP)-like (ABCB9) visualized in vivo with a fluorescence protein-fusion technique."
      Kobayashi A. , Maeda T. , Maeda M.
      Biol. Pharm. Bull.27:1916-1922(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DOMAIN
    11. 11.
      "Selective and ATP-dependent translocation of peptides by the homodimeric ATP binding cassette transporter TAP-like (ABCB9)."
      Wolters J.C. , Abele R. , Tampe R.
      J. Biol. Chem.280:23631-23636(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;BIOPHYSICOCHEMICAL PROPERTIES;SUBUNIT
    12. 12.
      "Identification of a lysosomal peptide transport system induced during dendritic cell development."
      Demirel O. , Waibler Z. , Kalinke U. , Grunebach F. , Appel S. , Brossart P. , Hasilik A. , Tampe R. , Abele R.
      J. Biol. Chem.282:37836-37843(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS]
      tissue: Placenta.
    14. 14.
      "Functional dissection of transmembrane domains of human TAP-like (ABCB9)."
      Kamakura A. , Fujimoto Y. , Motohashi Y. , Ohashi K. , Ohashi-Kobayashi A. , Maeda M.
      Biochem. Biophys. Res. Commun.377:847-851(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    15. 15.
      "Biochemical characterization of transporter associated with antigen processing (TAP)-like (ABCB9) expressed in insect cells."
      Ohara T. , Ohashi-Kobayashi A. , Maeda M.
      Biol. Pharm. Bull.31:1-5(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DOMAIN
    16. 16.
      "Peptide specificity and lipid activation of the lysosomal transport complex ABCB9 (TAPL)."
      Zhao C. , Haase W. , Tampe R. , Abele R.
      J. Biol. Chem.283:17083-17091(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Tuning the cellular trafficking of the lysosomal peptide transporter TAPL by its N-terminal domain."
      Demirel O. , Bangert I. , Tampe R. , Abele R.
      Traffic11:383-393(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;DOMAIN;MUTAGENESIS OF 136-LYS-LYS-137
    18. 18.
      "Transporter associated with antigen processing-like (ABCB9) stably expressed in Chinese hamster ovary-K1 cells is sorted to the microdomains of lysosomal membranes."
      Fujimoto Y. , Kamakura A. , Motohashi Y. , Ohashi-Kobayashi A. , Maeda M.
      Biol. Pharm. Bull.34:36-40(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    19. 19.
      "Three hundred twenty-six genetic variations in genes encoding nine members of ATP-binding cassette, subfamily B (ABCB/MDR/TAP), in the Japanese population."
      Saito S. , Iida A. , Sekine A. , Miura Y. , Ogawa C. , Kawauchi S. , Higuchi S. , Nakamura Y.
      J. Hum. Genet.47:38-50(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-121
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