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Index > Protein center > Acaca(Gene name) > Mouse
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  • Acaca (Gene name),
  • Acetyl-CoA carboxylase 1 (Protein name ),  ACACA_MOUSE from NCBI database.
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  • General Annotation
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  • Gene name:
    Acaca(Acac;Gm738);
    Protein name:
    Acetyl-CoA carboxylase 1(ACC1);
    Alternative:
    Acetyl-CoA carboxylase 265;ACC-alpha;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
    Function:
    Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    2345
    Sequence:
    50:
    MDEPSPLAKT | LELNQHSRFI | IGSVSEDNSE | DEISNLVKLD | LEEKEGSLSP | 
    100:
    ASVSSDTLSD | LGISGLQDGL | AFHMRSSMSG | LHLVKQGRDR | KKIDSQRDFT | 
    150:
    VASPAEFVTR | FGGNKVIEKV | LIANNGIAAV | KCMRSIRRWS | YEMFRNERAI | 
    200:
    RFVVMVTPED | LKANAEYIKM | ADHYVPVPGG | PNNNNYANVE | LILDIAKRIP | 
    250:
    VQAVWAGWGH | ASENPKLPEL | LLKNGIAFMG | PPSQAMWALG | DKIASSIVAQ | 
    300:
    TAGIPTLPWS | GSGLRVDWQE | NDFSKRILNV | PQDLYEKGYV | KDVDDGLKAA | 
    350:
    EEVGYPVMIK | ASEGGGGKGI | RKVNNADDFP | NLFRQVQAEV | PGSPIFVMRL | 
    400:
    AKQSRHLEVQ | ILADQYGNAI | SLFGRDCSVQ | RRHQKIIEEA | PAAIATPAVF | 
    450:
    EHMEQCAVKL | AKMVGYVSAG | TVEYLYSQDG | SFYFLELNPR | LQVEHPCTEM | 
    500:
    VADVNLPAAQ | LQIAMGIPLF | RIKDIRMMYG | VSPWGDAPID | FENSAHVPCP | 
    550:
    RGHVIAARIT | SENPDEGFKP | SSGTVQELNF | RSNKNVWGYF | SVAAAGGLHE | 
    600:
    FADSQFGHCF | SWGENREEAI | SNMVVALKEL | SIRGDFRTTV | EYLIKLLETE | 
    650:
    SFQLNRIDTG | WLDRLIAEKV | QAERPDTMLG | VVCGALHVAD | VSLRNSISNF | 
    700:
    LHSLERGQVL | PAHTLLNTVD | VELIYEGIKY | VLKVTRQSPN | SYVVIMNGSC | 
    750:
    VEVDVHRLSD | GGLLLSYDGS | SYTTYMKEEV | DRYRITIGNK | TCVFEKENDP | 
    800:
    SVMRSPSAGK | LIQYIVEDGG | HVFAGQCYAE | IEVMKMVMTL | TAVESGCIHY | 
    850:
    VKRPGAALDP | GCVIAKMQLD | NPSKVQQAEL | HTGSLPQIQS | TALRGEKLHR | 
    900:
    VFHYVLDNLV | NVMNGYCLPD | PFFSSRVKDW | VERLMKTLRD | PSLPLLELQD | 
    950:
    IMTSVSGRIP | LNVEKSIKKE | MAQYASNITS | VLCQFPSQQI | ANILDSHAAT | 
    1000:
    LNRKSEREVF | FMNTQSIVQL | VQRYRSGIRG | HMKAVVMDLL | RQYLRVETQF | 
    1050:
    QNGHYDKCVF | ALREENKSDM | NTVLNYIFSH | AQVTKKNLLV | TMLIDQLCGR | 
    1100:
    DPTLTDELLN | ILTELTQLSK | TTNAKVALRA | RQVLIASHLP | SYELRHNQVE | 
    1150:
    SIFLSAIDMY | GHQFCIENLQ | KLILSETSIF | DVLPNFFYHS | NQVVRMAALE | 
    1200:
    VYVRRAYIAY | ELNSVQHRQL | KDNTCVVEFQ | FMLPTSHPNR | GNIPTLNRMS | 
    1250:
    FASNLNHYGM | THVASVSDVL | LDNAFTPPCQ | RMGGMVSFRT | FEDFVRIFDE | 
    1300:
    IMGCFCDSPP | QSPTFPESGH | TSLYDEDKVP | RDEPIHILNV | AIKTDGDIED | 
    1350:
    DRLAAMFREF | TQQNKATLVE | HGIRRLTFLV | AQKDFRKQVN | CEVDQRFHRE | 
    1400:
    FPKFFTFRAR | DKFEEDRIYR | HLEPALAFQL | ELNRMRNFDL | TAIPCANHKM | 
    1450:
    HLYLGAAKVE | VGTEVTDYRF | FVRAIIRHSD | LVTKEASFEY | LQNEGERLLL | 
    1500:
    EAMDELEVAF | NNTNVRTDCN | HIFLNFVPTV | IMDPSKIEES | VRSMVMRYGS | 
    1550:
    RLWKLRVLQA | ELKINIRLTT | TGKAIPIRLF | LTNESGYYLD | ISLYKEVTDS | 
    1600:
    RTAQIMFQAY | GDKQGPLHGM | LINTPYVTKD | LLQSKRFQAQ | SLGTTYIYDI | 
    1650:
    PEMFRQSLIK | LWESMSTQAF | LPSPPLPSDI | LTYTELVLDD | QGQLVHMNRL | 
    1700:
    PGGNEIGMVA | WKMSLKSPEY | PDGRDIIVIG | NDITYRIGSF | GPQEDLLFLR | 
    1750:
    ASELARAEGI | PRIYVAANSG | ARIGLAEEIR | HMFHVAWVDP | EDPYKGYKYL | 
    1800:
    YLTPQDYKRV | SALNSVHCEH | VEDEGESRYK | ITDIIGKEEG | LGAENLRGSG | 
    1850:
    MIAGESSLAY | DEVITISLVT | CRAIGIGAYL | VRLGQRTIQV | ENSHLILTGA | 
    1900:
    GALNKVLGRE | VYTSNNQLGG | IQIMHNNGVT | HSTVCDDFEG | VFTVLHWLSY | 
    1950:
    MPKSVHSSVP | LLNSKDPIDR | IIEFVPTKAP | YDPRWMLAGR | PHPTQKGQWL | 
    2000:
    SGFFDYGSFS | EIMQPWAQTV | VVGRARLGGI | PVGVVAVETR | TVELSIPADP | 
    2050:
    ANLDSEAKII | QQAGQVWFPD | SAFKTYQAIK | DFNREGLPLM | VFANWRGFSG | 
    2100:
    GMKDMYDQVL | KFGAYIVDGL | RECSQPVMVY | IPPQAELRGG | SWVVIDPTIN | 
    2150:
    PRHMEMYADR | ESRGSVLEPE | GTVEIKFRKK | DLVKTMRRVD | PVYIRLAERL | 
    2200:
    GTPELSPTER | KELESKLKER | EEFLIPIYHQ | VAVQFADLHD | TPGRMQEKGV | 
    2250:
    INDILDWKTS | RTFFYWRLRR | LLLEDLVKKK | IHNANPELTD | GQIQAMLRRW | 
    2300:
    FVEVEGTVKA | YVWDNNKDLV | EWLEKQLTEE | DGVRSVIEEN | IKYISRDYVL | 
    2345:
    KQIRSLVQAN | PEVAMDSIVH | MTQHISPTQR | AEVVRILSTM | DSPST
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    UniGene:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse ACC1
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    ELISA Kit for Mouse ACC1
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    CLIA Kit for Mouse ACC1
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    Packing:
    96T
    CLIA Kit for Mouse ACC1
    Cat.:
    U1284h
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    CLIA Kit for Mouse ACC1
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    U1284b
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    96T
    Polyclonal Antibody for Mouse ACC1
    Cat.:
    P1284Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse ACC1
    Cat.:
    P1284Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse ACC1
    Cat.:
    P1284Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse ACC1
    Monoclonal Antibody for Mouse ACC1
    Monoclonal Antibody for Mouse ACC1
    Monoclonal Antibody for Mouse ACC1
    Monoclonal Antibody for Mouse ACC1
    Protein for Mouse ACC1
    Protein for Mouse ACC1
    Protein for Mouse ACC1
    Protein for Mouse ACC1

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    References
    1. 1.
      "Characterization of the mouse acetyl-CoA carboxylase 1 (ACC1) gene and identification of an intronless pseudogene."
      Mao J. , Wakil S.J.
      Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: C57BL/6J.
      tissue: Liver.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    3. 3.
      "Asymmetric expression of transcripts derived from the shared promoter between the divergently oriented ACACA and TADA2L genes."
      Travers M.T. , Cambot M. , Kennedy H.T. , Lenoir G.M. , Barber M.C. , Joulin V.
      Genomics85:71-84(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-119 (ISOFORM 2)
      strain: Swiss.
      tissue: Brain.
    4. 4.
      "Acetyl-CoA carboxylase and SREBP expression during peripheral nervous system myelination."
      Salles J. , Sargueil F. , Knoll-Gellida A. , Witters L.A. , Cassagne C. , Garbay B.
      Biochim. Biophys. Acta1631:229-238(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-38; 1221-1348 AND 1681-1891
      strain: C57BL/6.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1501-2345
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      "BRCA1 interacts with acetyl-CoA carboxylase through its tandem of BRCT domains."
      Magnard C. , Bachelier R. , Vincent A. , Jaquinod M. , Kieffer S. , Lenoir G.M. , Venezia N.D.
      Oncogene21:6729-6739(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 298-306 AND 2267-2275;INTERACTION WITH BRCA1;SUBCELLULAR LOCATION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25 AND SER-29;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    8. 8.
      "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
      Zhou H. , Ye M. , Dong J. , Han G. , Jiang X. , Wu R. , Zou H.
      J. Proteome Res.7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29 AND SER-79;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
    9. 9.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;ENZYME REGULATION;INTERACTION WITH MID1IP1;PHOSPHORYLATION AT SER-79;SUBCELLULAR LOCATION
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