Acetyl-CoA carboxylase 1 (Protein name
), ACACA_MOUSE from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
Acaca(Acac;Gm738);
Protein name:
Acetyl-CoA carboxylase 1(ACC1);
Alternative:
Acetyl-CoA carboxylase 265;ACC-alpha;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer, homodimer, and homotetramer. Can form filamentous polymers. Interacts in its inactive phosphorylated form with the BRCT domains of BRCA1 which prevents ACACA dephosphorylation and inhibits lipid synthesis. Interacts with MID1IP1; interaction with MID1IP1 promotes oligomerization and increases its activity.
Function:
Catalyzes the rate-limiting reaction in the biogenesis of long-chain fatty acids. Carries out three functions: biotin carboxyl carrier protein, biotin carboxylase and carboxyltransferase.
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Precision
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Recovery
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Linearity
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References
1.
"Characterization of the mouse acetyl-CoA carboxylase 1 (ACC1) gene and identification of an intronless pseudogene." Mao J.
,
Wakil S.J.
Submitted (2003-10) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 1-119 (ISOFORM 2)
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-38; 1221-1348 AND 1681-1891
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1501-2345
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Cited for: PROTEIN SEQUENCE OF 298-306 AND 2267-2275;INTERACTION WITH BRCA1;SUBCELLULAR LOCATION
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-25 AND SER-29;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-29 AND SER-79;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-79;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBUNIT;ENZYME REGULATION;INTERACTION WITH MID1IP1;PHOSPHORYLATION AT SER-79;SUBCELLULAR LOCATION
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