Gene name:
ACE2 (UNQ868/PRO1885) ;
Protein name:
Angiotensin-converting enzyme 2 ;
Alternative:
Angiotensin-converting enzyme homolog (ACEH) ;ACE-related carboxypeptidase ;Metalloprotease MPROT15 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein.
Function:
Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MSSSSWLLLS | LVAVTAAQST | IEEQAKTFLD | KFNHEAEDLF | YQSSLASWNY |
100:
NTNITEENVQ | NMNNAGDKWS | AFLKEQSTLA | QMYPLQEIQN | LTVKLQLQAL |
150:
QQNGSSVLSE | DKSKRLNTIL | NTMSTIYSTG | KVCNPDNPQE | CLLLEPGLNE |
200:
IMANSLDYNE | RLWAWESWRS | EVGKQLRPLY | EEYVVLKNEM | ARANHYEDYG |
250:
DYWRGDYEVN | GVDGYDYSRG | QLIEDVEHTF | EEIKPLYEHL | HAYVRAKLMN |
300:
AYPSYISPIG | CLPAHLLGDM | WGRFWTNLYS | LTVPFGQKPN | IDVTDAMVDQ |
350:
AWDAQRIFKE | AEKFFVSVGL | PNMTQGFWEN | SMLTDPGNVQ | KAVCHPTAWD |
400:
LGKGDFRILM | CTKVTMDDFL | TAHHEMGHIQ | YDMAYAAQPF | LLRNGANEGF |
450:
HEAVGEIMSL | SAATPKHLKS | IGLLSPDFQE | DNETEINFLL | KQALTIVGTL |
500:
PFTYMLEKWR | WMVFKGEIPK | DQWMKKWWEM | KREIVGVVEP | VPHDETYCDP |
550:
ASLFHVSNDY | SFIRYYTRTL | YQFQFQEALC | QAAKHEGPLH | KCDISNSTEA |
600:
GQKLFNMLRL | GKSEPWTLAL | ENVVGAKNMN | VRPLLNYFEP | LFTWLKDQNK |
650:
NSFVGWSTDW | SPYADQSIKV | RISLKSALGD | KAYEWNDNEM | YLFRSSVAYA |
700:
MRQYFLKVKN | QMILFGEEDV | RVANLKPRIS | FNFFVTAPKN | VSDIIPRTEV |
750:
EKAIRMSRSR | INDAFRLNDN | SLEFLGIQPT | LGPPNQPPVS | IWLIVFGVVM |
800:
GVIVVGIVIL | IFTGIRDRKK | KNKARSGENP | YASIDISKGE | NNPGFQNTDD |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Bovine
ELISA Kit for Human Angiotensin-converting enzyme 2
ELISA Kit for Human Angiotensin-converting enzyme 2
ELISA Kit for Human Angiotensin-converting enzyme 2
ELISA Kit for Human Angiotensin-converting enzyme 2
CLIA Kit for Human Angiotensin-converting enzyme 2
CLIA Kit for Human Angiotensin-converting enzyme 2
CLIA Kit for Human Angiotensin-converting enzyme 2
CLIA Kit for Human Angiotensin-converting enzyme 2
Polyclonal Antibody for Human Angiotensin-converting enzyme 2
Polyclonal Antibody for Human Angiotensin-converting enzyme 2
Polyclonal Antibody for Human Angiotensin-converting enzyme 2
Polyclonal Antibody for Human Angiotensin-converting enzyme 2
Monoclonal Antibody for Human Angiotensin-converting enzyme 2
Monoclonal Antibody for Human Angiotensin-converting enzyme 2
Monoclonal Antibody for Human Angiotensin-converting enzyme 2
Monoclonal Antibody for Human Angiotensin-converting enzyme 2
Protein for Human Angiotensin-converting enzyme 2
Protein for Human Angiotensin-converting enzyme 2
Protein for Human Angiotensin-converting enzyme 2
Protein for Human Angiotensin-converting enzyme 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9."
Donoghue M.
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Hsieh F.
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Baronas E.
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Godbout K.
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Gosselin M.
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Stagliano N.
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Donovan M.
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Breitbart R.E.
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Acton S.
Circ. Res.87:E1-E9(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;FUNCTION;ENZYME REGULATION
tissue :
Heart .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;GLYCOSYLATION;FUNCTION;ENZYME REGULATION
tissue :
Lymphoma .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;ENZYME REGULATION
tissue :
Testis .
4.
"Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population."
Itoyama S.
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Keicho N.
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Hijikata M.
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Quy T.
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Phi N.C.
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Long H.T.
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Ha L.D.
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Matsushita I.
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Yanai H.
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Kirikae F.
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Sasazuki T.
Am. J. Med. Genet. A136:52-57(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-638
tissue :
Lung .
tissue :
Testis .
5.
"Cloning, expression analysis and chromosomal localization of a novel ACE like enzyme."
Suzuki Y.
,
Watanabe M.
,
Sugano S.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
8.
"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F.
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Gurney A.L.
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Abaya E.
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Baker K.
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Baldwin D.T.
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Brush J.
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Chen J.
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Klimowski L.
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Lee J.
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Lewis L.
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Liao D.
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Mark M.R.
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Robbie E.
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Smith V.
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Watanabe C.
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Wieand D.
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Woods K.
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Xie M.-H.
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Yansura D.G.
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Yi S.
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Yu G.
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Yuan J.
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Zhang M.
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Zhang Z.
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Goddard A.D.
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Wood W.I.
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Godowski P.J.
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Gray A.M.
more...
Genome Res.13:2265-2270(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-26
10.
Mural R.J.
,
Istrail S.
,
Sutton G.
,
Florea L.
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Halpern A.L.
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Mobarry C.M.
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Dew I.
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Miller J.R.
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Flanigan M.J.
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Edwards N.J.
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Bolanos R.
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Fasulo D.
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Halldorsson B.V.
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Hannenhalli S.
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Turner R.
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Yooseph S.
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Lu F.
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Nusskern D.R.
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Shue B.C.
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Zheng X.H.
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Zhong F.
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Delcher A.L.
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Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
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Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Brain .
tissue :
Testis .
12.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
,
Rosenfelder H.
,
Duda A.
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Schmidt C.P.
,
Ernst U.
,
Wellenreuther R.
,
Mehrle A.
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Schuster C.
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Bahr A.
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Bloecker H.
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Heubner D.
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Hoerlein A.
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Michel G.
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Wedler H.
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Koehrer K.
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Poustka A.
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more...
BMC Genomics8:399-399(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-805 (ISOFORM 1)
tissue :
Testis .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 679-689;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH ITGB1
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
15.
"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase."
Vickers C.
,
Hales P.
,
Kaushik V.
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Dick L.
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Gavin J.
,
Tang J.
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Godbout K.
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Parsons T.
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Baronas E.
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Hsieh F.
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Acton S.
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Patane M.A.
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Nichols A.
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Tummino P.
J. Biol. Chem.277:14838-14843(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;COFACTOR
16.
"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus."
Li W.
,
Moore M.J.
,
Vasilieva N.
,
Sui J.
,
Wong S.-K.
,
Berne M.A.
,
Somasundaran M.
,
Sullivan J.L.
,
Luzuriaga K.
,
Greenough T.C.
,
Choe H.
,
Farzan M.
Nature426:450-454(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH SARS-COV SPIKE GLYCOPROTEIN;GLYCOSYLATION;IDENTIFICATION BY MASS SPECTROMETRY
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INDUCTION
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SARS-COV SPIKE GLYCOPROTEIN
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-90
tissue :
Bile .
21.
"Myocardial infarction increases ACE2 expression in rat and humans."
Burrell L.M.
,
Risvanis J.
,
Kubota E.
,
Dean R.G.
,
MacDonald P.S.
,
Lu S.
,
Tikellis C.
,
Grant S.L.
,
Lew R.A.
,
Smith A.I.
,
Cooper M.E.
,
Johnston C.I.
Eur. Heart J.26:369-375(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;INDUCTION
22.
"Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2."
Li W.
,
Zhang C.
,
Sui J.
,
Kuhn J.H.
,
Moore M.J.
,
Luo S.
,
Wong S.-K.
,
Huang I.-C.
,
Xu K.
,
Vasilieva N.
,
Murakami A.
,
He Y.
,
Marasco W.A.
,
Guan Y.
,
Choe H.
,
Farzan M.
EMBO J.24:1634-1643(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SARS-COV SPIKE GLYCOPROTEIN;MUTAGENESIS
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC CLEAVAGE
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HCOV-NL63 SPIKE GLYCOPROTEIN
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-546
tissue :
Liver .
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEOLYTIC CLEAVAGE
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;PROTEOLYTIC CLEAVAGE;INTERACTION WITH TMPRSS2
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;PROTEOLYTIC CLEAVAGE
29.
"ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis."
Towler P.
,
Staker B.
,
Prasad S.G.
,
Menon S.
,
Tang J.
,
Parsons T.
,
Ryan D.
,
Fisher M.
,
Williams D.
,
Dales N.A.
,
Patane M.A.
,
Pantoliano M.W.
J. Biol. Chem.279:17996-18007(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 19-615;X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 19-615 IN COMPLEX WITH MLN-4760;DISULFIDE BONDS;GLYCOSYLATION AT ASN-53; ASN-90; ASN-103; ASN-322; ASN-432 AND ASN-546