ACE2 ELISA Kit for Human(Homo sapiens) | EIAab.comACE2 ELISA Kit for Human(Homo sapiens)

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ACE2 (Gene name),

Angiotensin-converting enzyme 2 (Protein name ), ACE2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ACE2(UNQ868/PRO1885);

Protein name:

Angiotensin-converting enzyme 2;

Alternative:

Angiotensin-converting enzyme homolog(ACEH);ACE-related carboxypeptidase;Metalloprotease MPROT15;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with ITGB1. Interacts with SARS-CoV and HCoV-NL63 spike glycoprotein.

Function:

Carboxypeptidase which converts angiotensin I to angiotensin 1-9, a peptide of unknown function, and angiotensin II to angiotensin 1-7, a vasodilator. Also able to hydrolyze apelin-13 and dynorphin-13 with high efficiency. May be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, serve as functional receptor for the spike glycoprotein of both coronaviruses.

Subcellular Location:

Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

805

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

805:

VQTSF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9BYF1

UniGene:

Hs.178098

Pfam:

PF01401

KEGG:

hsa:59272

MIM:

300335

STRING:

9606.ENSP00000252519

SMR:

Q9BYF1

Uniprot:

Q9BYF1

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ELISA Kit for Human Angiotensin-converting enzyme 2

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E1886h

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96T

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ELISA Kit for Human Angiotensin-converting enzyme 2

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E1886r

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96T

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ELISA Kit for Human Angiotensin-converting enzyme 2

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E1886m

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ELISA Kit for Human Angiotensin-converting enzyme 2

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E1886b

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96T

CLIA Kit for Human Angiotensin-converting enzyme 2

Cat.:

U1886r

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96T

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CLIA Kit for Human Angiotensin-converting enzyme 2

Cat.:

U1886h

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Looking for manual.

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96T

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CLIA Kit for Human Angiotensin-converting enzyme 2

Cat.:

U1886m

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96T

CLIA Kit for Human Angiotensin-converting enzyme 2

Cat.:

U1886b

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96T

Polyclonal Antibody for Human Angiotensin-converting enzyme 2

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P1886Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Angiotensin-converting enzyme 2

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P1886Rb-m

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Polyclonal Antibody for Human Angiotensin-converting enzyme 2

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P1886Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human Angiotensin-converting enzyme 2

Protein for Human Angiotensin-converting enzyme 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9."
Donoghue M. , Hsieh F. , Baronas E. , Godbout K. , Gosselin M. , Stagliano N. , Donovan M. , Woolf B. , Robison K. , Jeyaseelan R. , Breitbart R.E. , Acton S.
Circ. Res.87:E1-E9(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;FUNCTION;ENZYME REGULATION
tissue: Heart.
2.

"A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase."
Tipnis S.R. , Hooper N.M. , Hyde R. , Karran E. , Christie G. , Turner A.J.
J. Biol. Chem.275:33238-33243(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;GLYCOSYLATION;FUNCTION;ENZYME REGULATION
tissue: Lymphoma.
3.

"The novel angiotensin-converting enzyme (ACE) homolog, ACE2, is selectively expressed by adult Leydig cells of the testis."
Douglas G.C. , O'Bryan M.K. , Hedger M.P. , Lee D.K.L. , Yarski M.A. , Smith A.I. , Lew R.A.
Endocrinology145:4703-4711(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;ENZYME REGULATION
tissue: Testis.
4.

"Identification of an alternative 5'-untranslated exon and new polymorphisms of angiotensin-converting enzyme 2 gene: lack of association with SARS in the Vietnamese population."
Itoyama S. , Keicho N. , Hijikata M. , Quy T. , Phi N.C. , Long H.T. , Ha L.D. , Ban V.V. , Matsushita I. , Yanai H. , Kirikae F. , Kirikae T. , Kuratsuji T. , Sasazuki T.
Am. J. Med. Genet. A136:52-57(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-638
tissue: Lung.
tissue: Testis.
5.

"Cloning, expression analysis and chromosomal localization of a novel ACE like enzyme."
Suzuki Y. , Watanabe M. , Sugano S.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
6.

"MPROT15 polypeptide and MPROT15 polynucleotide."
Southan C. , Burgess N.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
7.

"Comparative susceptibility to SARS-CoV mediated by ACE2 protein of 15 different species."
Li K.K.B. , Yip C.W. , Hon C.C. , Lam C.Y. , Leung F.C.C.
Submitted (2009-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
8.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
9.

SeattleSNPs variation discovery resource
Submitted (2003-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ARG-26
10.

Mural R.J. , Istrail S. , Sutton G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
tissue: Testis.
12.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-805 (ISOFORM 1)
tissue: Testis.
13.

"Interaction of ACE2 and integrin beta1 in failing human heart."
Lin Q. , Keller R.S. , Weaver B. , Zisman L.S.
Biochim. Biophys. Acta1689:175-178(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 679-689;IDENTIFICATION BY MASS SPECTROMETRY;INTERACTION WITH ITGB1
14.

"Quantitative mRNA expression profiling of ACE 2, a novel homologue of angiotensin converting enzyme."
Harmer D. , Gilbert M. , Borman R. , Clark K.L.
FEBS Lett.532:107-110(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
15.

"Hydrolysis of biological peptides by human angiotensin-converting enzyme-related carboxypeptidase."
Vickers C. , Hales P. , Kaushik V. , Dick L. , Gavin J. , Tang J. , Godbout K. , Parsons T. , Baronas E. , Hsieh F. , Acton S. , Patane M.A. , Nichols A. , Tummino P.
J. Biol. Chem.277:14838-14843(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES;ENZYME REGULATION;COFACTOR
16.

"Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus."
Li W. , Moore M.J. , Vasilieva N. , Sui J. , Wong S.-K. , Berne M.A. , Somasundaran M. , Sullivan J.L. , Luzuriaga K. , Greenough T.C. , Choe H. , Farzan M.
Nature426:450-454(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SARS-COV SPIKE GLYCOPROTEIN;GLYCOSYLATION;IDENTIFICATION BY MASS SPECTROMETRY
17.

"ACE2 gene expression is up-regulated in the human failing heart."
Goulter A.B. , Goddard M.J. , Allen J.C. , Clark K.L.
BMC Med.2:19-19(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
18.

"Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis."
Hamming I. , Timens W. , Bulthuis M.L.C. , Lely A.T. , Navis G.J. , van Goor H.
J. Pathol.203:631-637(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
19.

"Efficient replication of severe acute respiratory syndrome coronavirus in mouse cells is limited by murine angiotensin-converting enzyme 2."
Li W. , Greenough T.C. , Moore M.J. , Vasilieva N. , Somasundaran M. , Sullivan J.L. , Farzan M. , Choe H.
J. Virol.78:11429-11433(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SARS-COV SPIKE GLYCOPROTEIN
20.

"A proteomic analysis of human bile."
Kristiansen T.Z. , Bunkenborg J. , Gronborg M. , Molina H. , Thuluvath P.J. , Argani P. , Goggins M.G. , Maitra A. , Pandey A.
Mol. Cell. Proteomics3:715-728(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-90
tissue: Bile.
21.

"Myocardial infarction increases ACE2 expression in rat and humans."
Burrell L.M. , Risvanis J. , Kubota E. , Dean R.G. , MacDonald P.S. , Lu S. , Tikellis C. , Grant S.L. , Lew R.A. , Smith A.I. , Cooper M.E. , Johnston C.I.
Eur. Heart J.26:369-375(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;INDUCTION
22.

"Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2."
Li W. , Zhang C. , Sui J. , Kuhn J.H. , Moore M.J. , Luo S. , Wong S.-K. , Huang I.-C. , Xu K. , Vasilieva N. , Murakami A. , He Y. , Marasco W.A. , Guan Y. , Choe H. , Farzan M.
EMBO J.24:1634-1643(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SARS-COV SPIKE GLYCOPROTEIN;MUTAGENESIS
23.

"Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)."
Lambert D.W. , Yarski M. , Warner F.J. , Thornhill P. , Parkin E.T. , Smith A.I. , Hooper N.M. , Turner A.J.
J. Biol. Chem.280:30113-30119(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC CLEAVAGE
24.

"Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry."
Hofmann H. , Pyrc K. , van der Hoek L. , Geier M. , Berkhout B. , Poehlmann S.
Proc. Natl. Acad. Sci. U.S.A.102:7988-7993(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HCOV-NL63 SPIKE GLYCOPROTEIN
25.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-546
tissue: Liver.
26.

"Angiotensin-converting enzyme 2 ectodomain shedding cleavage-site identification: determinants and constraints."
Lai Z.W. , Hanchapola I. , Steer D.L. , Smith A.I.
Biochemistry50:5182-5194(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC CLEAVAGE
27.

"A transmembrane serine protease is linked to the severe acute respiratory syndrome coronavirus receptor and activates virus entry."
Shulla A. , Heald-Sargent T. , Subramanya G. , Zhao J. , Perlman S. , Gallagher T.
J. Virol.85:873-882(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;PROTEOLYTIC CLEAVAGE;INTERACTION WITH TMPRSS2
28.

"TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."
Heurich A. , Hofmann-Winkler H. , Gierer S. , Liepold T. , Jahn O. , Poehlmann S.
J. Virol.88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PROTEOLYTIC CLEAVAGE
29.

"ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis."
Towler P. , Staker B. , Prasad S.G. , Menon S. , Tang J. , Parsons T. , Ryan D. , Fisher M. , Williams D. , Dales N.A. , Patane M.A. , Pantoliano M.W.
J. Biol. Chem.279:17996-18007(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 19-615;X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 19-615 IN COMPLEX WITH MLN-4760;DISULFIDE BONDS;GLYCOSYLATION AT ASN-53; ASN-90; ASN-103; ASN-322; ASN-432 AND ASN-546

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