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Index > Protein center > ACHE(Gene name) > Human
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  • ACHE (Gene name),
  • Acetylcholinesterase (Protein name ),  ACES_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    ACHE;
    Protein name:
    Acetylcholinesterase(AChE);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers (By similarity). Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers. Isoform R may be monomeric.
    Function:
    Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.
    Subcellular Location:
    Isoform H Cell membrane Lipid-anchor GPI-anchor Extracellular side
    Protein Attributes:
    Sequence length:
    614
    Sequence:
    50:
    MRPPQCLLHT | PSLASPLLLL | LLWLLGGGVG | AEGREDAELL | VTVRGGRLRG | 
    100:
    IRLKTPGGPV | SAFLGIPFAE | PPMGPRRFLP | PEPKQPWSGV | VDATTFQSVC | 
    150:
    YQYVDTLYPG | FEGTEMWNPN | RELSEDCLYL | NVWTPYPRPT | SPTPVLVWIY | 
    200:
    GGGFYSGASS | LDVYDGRFLV | QAERTVLVSM | NYRVGAFGFL | ALPGSREAPG | 
    250:
    NVGLLDQRLA | LQWVQENVAA | FGGDPTSVTL | FGESAGAASV | GMHLLSPPSR | 
    300:
    GLFHRAVLQS | GAPNGPWATV | GMGEARRRAT | QLAHLVGCPP | GGTGGNDTEL | 
    350:
    VACLRTRPAQ | VLVNHEWHVL | PQESVFRFSF | VPVVDGDFLS | DTPEALINAG | 
    400:
    DFHGLQVLVG | VVKDEGSYFL | VYGAPGFSKD | NESLISRAEF | LAGVRVGVPQ | 
    450:
    VSDLAAEAVV | LHYTDWLHPE | DPARLREALS | DVVGDHNVVC | PVAQLAGRLA | 
    500:
    AQGARVYAYV | FEHRASTLSW | PLWMGVPHGY | EIEFIFGIPL | DPSRNYTAEE | 
    550:
    KIFAQRLMRY | WANFARTGDP | NEPRDPKAPQ | WPPYTAGAQQ | YVSLDLRPLE | 
    600:
    VRRGLRAQAC | AFWNRFLPKL | LSATDTLDEA | ERQWKAEFHR | WSSYMVHWKN | 
    614:
    QFDHYSKQDR | CSDL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    KEGG:
    MIM:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human AChE
    Cat.:
    E1195r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human AChE
    Cat.:
    E1195m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human AChE
    Cat.:
    E1195h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Human AChE
    MSDS:
    Please sign in first.
    ELISA Kit for Human AChE
    Cat.:
    E1195c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human AChE
    Cat.:
    E1195b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AChE
    Cat.:
    U1195b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AChE
    Cat.:
    U1195r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AChE
    Cat.:
    U1195h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human AChE
    Cat.:
    U1195c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AChE
    Cat.:
    U1195m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human AChE
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human AChE
    Polyclonal Antibody for Human AChE
    Cat.:
    P1195Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AChE
    Cat.:
    P1195Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AChE
    Polyclonal Antibody for Human AChE
    Polyclonal Antibody for Human AChE
    Cat.:
    P1195Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human AChE
    Monoclonal Antibody for Human AChE
    Monoclonal Antibody for Human AChE
    Monoclonal Antibody for Human AChE
    Monoclonal Antibody for Human AChE
    Monoclonal Antibody for Human AChE
    Protein for Human AChE
    Protein for Human AChE
    Protein for Human AChE
    Protein for Human AChE
    Protein for Human AChE
    Protein for Human AChE

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Molecular cloning and construction of the coding region for human acetylcholinesterase reveals a G + C-rich attenuating structure."
      Soreq H. , Ben-Aziz R. , Prody C.A. , Seidman S. , Gnatt A. , Neville L. , Lieman-Hurwitz J. , Lev-Lehman E. , Ginzberg D. , Lipidot-Lifson Y. , Zakut H.
      Proc. Natl. Acad. Sci. U.S.A.87:9688-9692(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM T)
    2. 2.
      "Expression of three alternative acetylcholinesterase messenger RNAs in human tumor cell lines of different tissue origins."
      Karpel R. , Ben Aziz-Aloya R. , Sternfeld M. , Ehrlich G. , Ginzberg D. , Tarroni P. , Clementi F. , Zakut H. , Soreq H.
      Exp. Cell Res.210:268-277(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS H; R AND T)
    3. 3.
      Yang L. , Zhang X.J.
      Submitted (2001-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM T)
    5. 5.
      Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM T)
      tissue: Brain.
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2004-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLN-34; ALA-135 AND ASN-353
    7. 7.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM H);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-546 (ISOFORMS H/R/T)
      tissue: Cerebellum.
      tissue: Hippocampus.
    10. 10.
      "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
      Wilson M.D. , Riemer C. , Martindale D.W. , Schnupf P. , Boright A.P. , Cheung T.L. , Hardy D.M. , Schwartz S. , Scherer S.W. , Tsui L.-C. , Miller W. , Koop B.F.
      Nucleic Acids Res.29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 521-614
    11. 11.
      "Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase."
      Chhajlani V. , Derr D. , Earles B. , Schmell E. , August T.
      FEBS Lett.247:279-282(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 256-273; 306-326; 396-422; 465-480 AND 528-551;FUNCTION;TISSUE SPECIFICITY
      tissue: Erythrocyte.
    12. 12.
      "The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580-->Ala mutant."
      Velan B. , Grosfeld H. , Kronman C. , Leitner M. , Gozes Y. , Lazar A. , Flashner Y. , Marcus D. , Cohen S. , Shafferman A.
      J. Biol. Chem.266:23977-23984(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-611
    13. 13.
      "Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding."
      Shafferman A. , Kronman C. , Flashner Y. , Leitner M. , Grosfeld H. , Ordentlich A. , Gozes Y. , Cohen S. , Ariel N. , Barak D.
      J. Biol. Chem.267:17640-17648(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-206; SER-234; GLU-365; ASP-435 AND HIS-478
    14. 14.
      "Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells."
      Yang L. , He H.Y. , Zhang X.J.
      Neurosci. Res.42:261-268(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    15. 15.
      "External and internal electrostatic potentials of cholinesterase models."
      Felder C.E. , Botti S.A. , Lifson S. , Silman I. , Sussman J.L.
      J. Mol. Graph. Model.15:318-327(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 35-574
    16. 16.
      "Structures of recombinant native and E202Q mutant human acetylcholinesterase complexed with the snake-venom toxin fasciculin-II."
      Kryger G. , Harel M. , Giles K. , Toker L. , Velan B. , Lazar A. , Kronman C. , Barak D. , Ariel N. , Shafferman A. , Silman I. , Sussman J.L.
      Acta Crystallogr. D56:1385-1394(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS) OF 32-614 IN COMPLEX WITH FASCICULIN-2;GLYCOSYLATION AT ASN-381 AND ASN-495;DISULFIDE BOND
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      "The synaptic acetylcholinesterase tetramer assembles around a polyproline II helix."
      Dvir H. , Harel M. , Bon S. , Liu W.-Q. , Vidal M. , Garbay C. , Sussman J.L. , Massoulie J. , Silman I.
      EMBO J.23:4394-4405(2004) [PubMed] [Europe PMC] [Abstract]
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.95 ANGSTROMS) OF COMPLEX WITH FASCICULIN-2;DISULFIDE BOND;GLYCOSYLATION AT ASN-381
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.60 ANGSTROMS) OF 35-573 IN COMPLEX WITH FASCICULIN-2; HUPERZINE A; GALANTAMINE AND DONEPEZIL;GLYCOSYLATION AT ASN-381 AND ASN-495;DISULFIDE BOND
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.10 ANGSTROMS) OF 36-598 IN COMPLEX WITH FASCICULIN-2 AND HUPRINE W;DISULFIDE BOND;GLYCOSYLATION AT ASN-381
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