Protein name:
Acetylcholinesterase (AChE) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers (By similarity). Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers.
Function:
Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
Subcellular Location:
Isoform H
Cell membrane
Lipid-anchor
GPI-anchor
Extracellular side
Protein Attributes:
50:
MRPPWYPLHT | PSLAFPLLFL | LLSLLGGGAR | AEGREDPQLL | VRVRGGQLRG |
100:
IRLKAPGGPV | SAFLGIPFAE | PPVGSRRFMP | PEPKRPWSGV | LDATTFQNVC |
150:
YQYVDTLYPG | FEGTEMWNPN | RELSEDCLYL | NVWTPYPRPA | SPTPVLIWIY |
200:
GGGFYSGAAS | LDVYDGRFLA | QVEGAVLVSM | NYRVGTFGFL | ALPGSREAPG |
250:
NVGLLDQRLA | LQWVQENIAA | FGGDPMSVTL | FGESAGAASV | GMHILSLPSR |
300:
SLFHRAVLQS | GTPNGPWATV | SAGEARRRAT | LLARLVGCPP | GGAGGNDTEL |
350:
IACLRTRPAQ | DLVDHEWHVL | PQESIFRFSF | VPVVDGDFLS | DTPEALINTG |
400:
DFQDLQVLVG | VVKDEGSYFL | VYGVPGFSKD | NESLISRAQF | LAGVRIGVPQ |
450:
ASDLAAEAVV | LHYTDWLHPE | DPTHLRDAMS | AVVGDHNVVC | PVAQLAGRLA |
500:
AQGARVYAYI | FEHRASTLTW | PLWMGVPHGY | EIEFIFGLPL | DPSLNYTTEE |
550:
RIFAQRLMKY | WTNFARTGDP | NDPRDSKSPQ | WPPYTTAAQQ | YVSLNLKPLE |
600:
VRRGLRAQTC | AFWNRFLPKL | LSATDTLDEA | ERQWKAEFHR | WSSYMVHWKN |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Mouse
Human
Rabbit
Chicken
Bovine
Polyclonal Antibody for Mouse AChE
Polyclonal Antibody for Mouse AChE
Polyclonal Antibody for Mouse AChE
Polyclonal Antibody for Mouse AChE
Polyclonal Antibody for Mouse AChE
Polyclonal Antibody for Mouse AChE
Monoclonal Antibody for Mouse AChE
Monoclonal Antibody for Mouse AChE
Monoclonal Antibody for Mouse AChE
Monoclonal Antibody for Mouse AChE
Monoclonal Antibody for Mouse AChE
Monoclonal Antibody for Mouse AChE
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
2.
"Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
Wilson M.D.
,
Riemer C.
,
Martindale D.W.
,
Schnupf P.
,
Boright A.P.
,
Cheung T.L.
,
Hardy D.M.
,
Schwartz S.
,
Scherer S.W.
,
Tsui L.-C.
,
Miller W.
,
Koop B.F.
Nucleic Acids Res.29:1352-1365(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain :
129/Sv .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Retina .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PRIMA1
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF COMPLEX WITH FASCICULIN-2;DISULFIDE BOND
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS)
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 34-573 IN COMPLEX WITH INHIBITOR