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Index > Protein center > Ache(Gene name) > Mouse
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  • Ache (Gene name),
  • Acetylcholinesterase (Protein name ),  ACES_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Ache;
    Protein name:
    Acetylcholinesterase(AChE);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Isoform H generates GPI-anchored dimers; disulfide linked. Isoform T generates multiple structures, ranging from monomers and dimers to collagen-tailed and hydrophobic-tailed forms, in which catalytic tetramers are associated with anchoring proteins that attach them to the basal lamina or to cell membranes. In the collagen-tailed forms, isoform T subunits are associated with a specific collagen, COLQ, which triggers the formation of isoform T tetramers, from monomers and dimers (By similarity). Interacts with PRIMA1. The interaction with PRIMA1 is required to anchor it to the basal lamina of cells and organize into tetramers.
    Function:
    Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
    Subcellular Location:
    Isoform H Cell membrane Lipid-anchor GPI-anchor Extracellular side
    Protein Attributes:
    Sequence length:
    614
    Sequence:
    50:
    MRPPWYPLHT | PSLAFPLLFL | LLSLLGGGAR | AEGREDPQLL | VRVRGGQLRG | 
    100:
    IRLKAPGGPV | SAFLGIPFAE | PPVGSRRFMP | PEPKRPWSGV | LDATTFQNVC | 
    150:
    YQYVDTLYPG | FEGTEMWNPN | RELSEDCLYL | NVWTPYPRPA | SPTPVLIWIY | 
    200:
    GGGFYSGAAS | LDVYDGRFLA | QVEGAVLVSM | NYRVGTFGFL | ALPGSREAPG | 
    250:
    NVGLLDQRLA | LQWVQENIAA | FGGDPMSVTL | FGESAGAASV | GMHILSLPSR | 
    300:
    SLFHRAVLQS | GTPNGPWATV | SAGEARRRAT | LLARLVGCPP | GGAGGNDTEL | 
    350:
    IACLRTRPAQ | DLVDHEWHVL | PQESIFRFSF | VPVVDGDFLS | DTPEALINTG | 
    400:
    DFQDLQVLVG | VVKDEGSYFL | VYGVPGFSKD | NESLISRAQF | LAGVRIGVPQ | 
    450:
    ASDLAAEAVV | LHYTDWLHPE | DPTHLRDAMS | AVVGDHNVVC | PVAQLAGRLA | 
    500:
    AQGARVYAYI | FEHRASTLTW | PLWMGVPHGY | EIEFIFGLPL | DPSLNYTTEE | 
    550:
    RIFAQRLMKY | WTNFARTGDP | NDPRDSKSPQ | WPPYTTAAQQ | YVSLNLKPLE | 
    600:
    VRRGLRAQTC | AFWNRFLPKL | LSATDTLDEA | ERQWKAEFHR | WSSYMVHWKN | 
    614:
    QFDHYSKQER | CSDL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    String:
    SMR:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse AChE
    Cat.:
    E1195r
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    Packing:
    96T
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    ELISA Kit for Mouse AChE
    Cat.:
    E1195m
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Mouse AChE
    Cat.:
    E1195h
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    ELISA Kit for Mouse AChE
    MSDS:
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    ELISA Kit for Mouse AChE
    Cat.:
    E1195c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse AChE
    Cat.:
    E1195b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AChE
    Cat.:
    U1195b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AChE
    Cat.:
    U1195r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AChE
    Cat.:
    U1195h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse AChE
    Cat.:
    U1195c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse AChE
    Cat.:
    U1195m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse AChE
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Mouse AChE
    Polyclonal Antibody for Mouse AChE
    Cat.:
    P1195Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse AChE
    Cat.:
    P1195Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse AChE
    Polyclonal Antibody for Mouse AChE
    Polyclonal Antibody for Mouse AChE
    Cat.:
    P1195Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse AChE
    Monoclonal Antibody for Mouse AChE
    Monoclonal Antibody for Mouse AChE
    Monoclonal Antibody for Mouse AChE
    Monoclonal Antibody for Mouse AChE
    Monoclonal Antibody for Mouse AChE
    Protein for Mouse AChE
    Protein for Mouse AChE
    Protein for Mouse AChE
    Protein for Mouse AChE
    Protein for Mouse AChE
    Protein for Mouse AChE

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    References
    1. 1.
      "Molecular cloning of mouse acetylcholinesterase: tissue distribution of alternatively spliced mRNA species."
      Rachinsky T.L. , Camp S. , Li Y. , Ekstroem T.J. , Newton M. , Taylor P.
      Neuron5:317-327(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5."
      Wilson M.D. , Riemer C. , Martindale D.W. , Schnupf P. , Boright A.P. , Cheung T.L. , Hardy D.M. , Schwartz S. , Scherer S.W. , Tsui L.-C. , Miller W. , Koop B.F.
      Nucleic Acids Res.29:1352-1365(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      strain: 129/Sv.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Retina.
    4. 4.
      "PRiMA: the membrane anchor of acetylcholinesterase in the brain."
      Perrier A.L. , Massoulie J. , Krejci E.
      Neuron33:275-285(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRIMA1
    5. 5.
      "Acetylcholinesterase inhibition by fasciculin: crystal structure of the complex."
      Bourne Y. , Taylor P. , Marchot P.
      Cell83:503-512(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.2 ANGSTROMS) OF COMPLEX WITH FASCICULIN-2;DISULFIDE BOND
    6. 6.
      "Crystal structure of mouse acetylcholinesterase. A peripheral site-occluding loop in a tetrameric assembly."
      Bourne Y. , Taylor P. , Bougis P.E. , Marchot P.
      J. Biol. Chem.274:2963-2970(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.9 ANGSTROMS)
    7. 7.
      "Structural insights into ligand interactions at the acetylcholinesterase peripheral anionic site."
      Bourne Y. , Taylor P. , Radic Z. , Marchot P.
      EMBO J.22:1-12(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 34-573 IN COMPLEX WITH INHIBITOR
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