Chrna10 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comChrna10 ELISA Kit for Rat(Rattus norvegicus)

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Chrna10 (Gene name),

Neuronal acetylcholine receptor subunit alpha-10 (Protein name ), ACH10_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Chrna10;

Protein name:

Neuronal acetylcholine receptor subunit alpha-10;

Alternative:

Nicotinic acetylcholine receptor subunit alpha-10(NACHR alpha-10);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Forms heterooligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 heterooligomers.

Function:

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this leads to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.

Subcellular Location:

Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

447

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

447:

STFRSHRAAQ | RRHEDWKRLA | RVMDRFFLGI | FFCMALVMSL | IVLVQAL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.48767

KEGG:

rno:64574

Pfam:

PF02931

STRING:

10116.ENSRNOP00000027506

Uniprot:

Q9JLB5

FOR

ELISA Kit for Rat Neuronal acetylcholine receptor subunit alpha-10

CLIA Kit for Rat Neuronal acetylcholine receptor subunit alpha-10

Polyclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-10

Monoclonal Antibody for Rat Neuronal acetylcholine receptor subunit alpha-10

Protein for Rat Neuronal acetylcholine receptor subunit alpha-10

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Alpha10: a determinant of nicotinic cholinergic receptor function in mammalian vestibular and cochlear mechanosensory hair cells."
Elgoyhen A.B. , Vetter D.E. , Katz E. , Rothlin C.V. , Heinemann S.F. , Boulter J.
Proc. Natl. Acad. Sci. U.S.A.98:3501-3506(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;INTERACTION WITH CHRNA9;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
strain: Sprague-Dawley.
2.

"The alpha9alpha10 nicotinic acetylcholine receptor is permeable to and is modulated by divalent cations."
Weisstaub N. , Vetter D.E. , Elgoyhen A.B. , Katz E.
Hear. Res.167:122-135(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CHRNA9
3.

"Coexpression of alpha 9 and alpha 10 nicotinic acetylcholine receptors in rat dorsal root ganglion neurons."
Lips K.S. , Pfeil U. , Kummer W.
Neuroscience115:1-5(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
4.

"Developmental regulation of nicotinic synapses on cochlear inner hair cells."
Katz E. , Elgoyhen A.B. , Gomez-Casati M.E. , Knipper M. , Vetter D.E. , Fuchs P.A. , Glowatzki E.
J. Neurosci.24:7814-7820(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
5.

"Pharmacological properties of alpha 9 alpha 10 nicotinic acetylcholine receptors revealed by heterologous expression of subunit chimeras."
Baker E.R. , Zwart R. , Sher E. , Millar N.S.
Mol. Pharmacol.65:453-460(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CHRNA9

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