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Index > Protein center > CHRNA2(Gene name) > Human
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  • CHRNA2 (Gene name),
  • Neuronal acetylcholine receptor subunit alpha-2 (Protein name ),  ACHA2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    CHRNA2;
    Protein name:
    Neuronal acetylcholine receptor subunit alpha-2;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors.
    Function:
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
    Subcellular Location:
    Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    529
    Sequence:
    50:
    MGPSCPVFLS | FTKLSLWWLL | LTPAGGEEAK | RPPPRAPGDP | LSSPSPTALP | 
    100:
    QGGSHTETED | RLFKHLFRGY | NRWARPVPNT | SDVVIVRFGL | SIAQLIDVDE | 
    150:
    KNQMMTTNVW | LKQEWSDYKL | RWNPTDFGNI | TSLRVPSEMI | WIPDIVLYNN | 
    200:
    ADGEFAVTHM | TKAHLFSTGT | VHWVPPAIYK | SSCSIDVTFF | PFDQQNCKMK | 
    250:
    FGSWTYDKAK | IDLEQMEQTV | DLKDYWESGE | WAIVNATGTY | NSKKYDCCAE | 
    300:
    IYPDVTYAFV | IRRLPLFYTI | NLIIPCLLIS | CLTVLVFYLP | SDCGEKITLC | 
    350:
    ISVLLSLTVF | LLLITEIIPS | TSLVIPLIGE | YLLFTMIFVT | LSIVITVFVL | 
    400:
    NVHHRSPSTH | TMPHWVRGAL | LGCVPRWLLM | NRPPPPVELC | HPLRLKLSPS | 
    450:
    YHWLESNVDA | EEREVVVEEE | DRWACAGHVA | PSVGTLCSHG | HLHSGASGPK | 
    500:
    AEALLQEGEL | LLSPHMQKAL | EGVHYIADHL | RSEDADSSVK | EDWKYVAMVI | 
    529:
    DRIFLWLFII | VCFLGTIGLF | LPPFLAGMI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    SMR:
    String:
    Pfam:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    E1926r
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    E1926h
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    E1926c
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    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    E1926m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    U1926c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    U1926h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    U1926r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    U1926m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    P1926Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    P1926Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
    Cat.:
    P1926Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
    Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
    Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
    Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
    Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
    Protein for Human Neuronal acetylcholine receptor subunit alpha-2
    Protein for Human Neuronal acetylcholine receptor subunit alpha-2
    Protein for Human Neuronal acetylcholine receptor subunit alpha-2
    Protein for Human Neuronal acetylcholine receptor subunit alpha-2

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    References
    1. 1.
      "Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
      Elliott K.J. , Ellis S.B. , Berckhan K.J. , Urrutia A. , Chavez-Noriega L.E. , Johnson E.C. , Velicelebi G. , Harpold M.M.
      J. Mol. Neurosci.7:217-228(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-125
      tissue: Hypothalamus.
    2. 2.
      Groot Kormelink P.J.
      Submitted (1998-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-125
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ALA-125
      tissue: Thalamus.
    4. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 6.
      "Increased sensitivity of the neuronal nicotinic receptor alpha2 subunit causes familial epilepsy with nocturnal wandering and ictal fear."
      Aridon P. , Marini C. , Di Resta C. , Brilli E. , De Fusco M. , Politi F. , Parrini E. , Manfredi I. , Pisano T. , Pruna D. , Curia G. , Cianchetti C. , Pasqualetti M. , Becchetti A. , Guerrini R. , Casari G.
      Am. J. Hum. Genet.79:342-350(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ENFL4 ASN-279;CHARACTERIZATION OF VARIANT ENFL4 ASN-279
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