Protein name:
Neuronal acetylcholine receptor subunit alpha-2 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Neuronal AChR seems to be composed of two different types of subunits: alpha and non-alpha (beta). Alpha-2 subunit can be combined to beta-2 or beta-4 to give rise to functional receptors.
Function:
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
Subcellular Location:
Cell junction
synapse
postsynaptic cell membrane
Multi-pass membrane protein
Cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MGPSCPVFLS | FTKLSLWWLL | LTPAGGEEAK | RPPPRAPGDP | LSSPSPTALP |
100:
QGGSHTETED | RLFKHLFRGY | NRWARPVPNT | SDVVIVRFGL | SIAQLIDVDE |
150:
KNQMMTTNVW | LKQEWSDYKL | RWNPTDFGNI | TSLRVPSEMI | WIPDIVLYNN |
200:
ADGEFAVTHM | TKAHLFSTGT | VHWVPPAIYK | SSCSIDVTFF | PFDQQNCKMK |
250:
FGSWTYDKAK | IDLEQMEQTV | DLKDYWESGE | WAIVNATGTY | NSKKYDCCAE |
300:
IYPDVTYAFV | IRRLPLFYTI | NLIIPCLLIS | CLTVLVFYLP | SDCGEKITLC |
350:
ISVLLSLTVF | LLLITEIIPS | TSLVIPLIGE | YLLFTMIFVT | LSIVITVFVL |
400:
NVHHRSPSTH | TMPHWVRGAL | LGCVPRWLLM | NRPPPPVELC | HPLRLKLSPS |
450:
YHWLESNVDA | EEREVVVEEE | DRWACAGHVA | PSVGTLCSHG | HLHSGASGPK |
500:
AEALLQEGEL | LLSPHMQKAL | EGVHYIADHL | RSEDADSSVK | EDWKYVAMVI |
529:
DRIFLWLFII | VCFLGTIGLF | LPPFLAGMI
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Chicken
Mouse
ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
ELISA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
CLIA Kit for Human Neuronal acetylcholine receptor subunit alpha-2
Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
Polyclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
Monoclonal Antibody for Human Neuronal acetylcholine receptor subunit alpha-2
Protein for Human Neuronal acetylcholine receptor subunit alpha-2
Protein for Human Neuronal acetylcholine receptor subunit alpha-2
Protein for Human Neuronal acetylcholine receptor subunit alpha-2
Protein for Human Neuronal acetylcholine receptor subunit alpha-2
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"Comparative structure of human neuronal alpha 2-alpha 7 and beta 2-beta 4 nicotinic acetylcholine receptor subunits and functional expression of the alpha 2, alpha 3, alpha 4, alpha 7, beta 2, and beta 4 subunits."
Elliott K.J.
,
Ellis S.B.
,
Berckhan K.J.
,
Urrutia A.
,
Chavez-Noriega L.E.
,
Johnson E.C.
,
Velicelebi G.
,
Harpold M.M.
J. Mol. Neurosci.7:217-228(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-125
tissue :
Hypothalamus .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-125
3.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);VARIANT ALA-125
tissue :
Thalamus .
4.
"DNA sequence and analysis of human chromosome 8."
Nusbaum C.
,
Mikkelsen T.S.
,
Zody M.C.
,
Asakawa S.
,
Taudien S.
,
Garber M.
,
Kodira C.D.
,
Schueler M.G.
,
Shimizu A.
,
Whittaker C.A.
,
Chang J.L.
,
Cuomo C.A.
,
Dewar K.
,
FitzGerald M.G.
,
Yang X.
,
Allen N.R.
,
Anderson S.
,
Asakawa T.
,
Blechschmidt K.
,
Bloom T.
,
Borowsky M.L.
,
Butler J.
,
Cook A.
,
Corum B.
,
DeArellano K.
,
DeCaprio D.
,
Dooley K.T.
,
Dorris L. III
,
Engels R.
,
Gloeckner G.
,
Hafez N.
,
Hagopian D.S.
,
Hall J.L.
,
Ishikawa S.K.
,
Jaffe D.B.
,
Kamat A.
,
Kudoh J.
,
Lehmann R.
,
Lokitsang T.
,
Macdonald P.
,
Major J.E.
,
Matthews C.D.
,
Mauceli E.
,
Menzel U.
,
Mihalev A.H.
,
Minoshima S.
,
Murayama Y.
,
Naylor J.W.
,
Nicol R.
,
Nguyen C.
,
O'Leary S.B.
,
O'Neill K.
,
Parker S.C.J.
,
Polley A.
,
Raymond C.K.
,
Reichwald K.
,
Rodriguez J.
,
Sasaki T.
,
Schilhabel M.
,
Siddiqui R.
,
Smith C.L.
,
Sneddon T.P.
,
Talamas J.A.
,
Tenzin P.
,
Topham K.
,
Venkataraman V.
,
Wen G.
,
Yamazaki S.
,
Young S.K.
,
Zeng Q.
,
Zimmer A.R.
,
Rosenthal A.
,
Birren B.W.
,
Platzer M.
,
Shimizu N.
,
Lander E.S.
more...
Nature439:331-335(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.
"Increased sensitivity of the neuronal nicotinic receptor alpha2 subunit causes familial epilepsy with nocturnal wandering and ictal fear."
Aridon P.
,
Marini C.
,
Di Resta C.
,
Brilli E.
,
De Fusco M.
,
Politi F.
,
Parrini E.
,
Manfredi I.
,
Pisano T.
,
Pruna D.
,
Curia G.
,
Cianchetti C.
,
Pasqualetti M.
,
Becchetti A.
,
Guerrini R.
,
Casari G.
Am. J. Hum. Genet.79:342-350(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT ENFL4 ASN-279;CHARACTERIZATION OF VARIANT ENFL4 ASN-279