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Index > Protein center > Chrm3(Gene name) > Rat
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  • Chrm3 (Gene name),
  • Muscarinic acetylcholine receptor M3 (Protein name ),  ACM3_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Chrm3(Chrm-3);
    Protein name:
    Muscarinic acetylcholine receptor M3;
    Alternative:

    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Basolateral cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    589
    Sequence:
    50:
    MTLHSNSTTS | PLFPNISSSW | VHSPSEAGLP | LGTVTQLGSY | NISQETGNFS | 
    100:
    SNDTSSDPLG | GHTIWQVVFI | AFLTGFLALV | TIIGNILVIV | AFKVNKQLKT | 
    150:
    VNNYFLLSLA | CADLIIGVIS | MNLFTTYIIM | NRWALGNLAC | DLWLSIDYVA | 
    200:
    SNASVMNLLV | ISFDRYFSIT | RPLTYRAKRT | TKRAGVMIGL | AWVISFVLWA | 
    250:
    PAILFWQYFV | GKRTVPPGEC | FIQFLSEPTI | TFGTAIAAFY | MPVTIMTILY | 
    300:
    WRIYKETEKR | TKELAGLQAS | GTEAEAENFV | HPTGSSRSCS | SYELQQQGVK | 
    350:
    RSSRRKYGRC | HFWFTTKSWK | PSAEQMDQDH | SSSDSWNNND | AAASLENSAS | 
    400:
    SDEEDIGSET | RAIYSIVLKL | PGHSSILNST | KLPSSDNLQV | SNEDLGTVDV | 
    450:
    ERNAHKLQAQ | KSMGDGDNCQ | KDFTKLPIQL | ESAVDTGKTS | DTNSSADKTT | 
    500:
    ATLPLSFKEA | TLAKRFALKT | RSQITKRKRM | SLIKEKKAAQ | TLSAILLAFI | 
    550:
    ITWTPYNIMV | LVNTFCDSCI | PKTYWNLGYW | LCYINSTVNP | VCYALCNKTF | 
    589:
    RTTFKTLLLC | QCDKRKRRKQ | QYQQRQSVIF | HKRVPEQAL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    E1838h
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    96T
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    ELISA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    E1838m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    E1838b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    E1838c
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    Packing:
    96T
    ELISA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    E1838p
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    Packing:
    96T
    ELISA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    E1838r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    U1838c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    U1838p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    U1838b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    U1838m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    U1838h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    U1838r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Polyclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Polyclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    P1838Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    P1838Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Cat.:
    P1838Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Monoclonal Antibody for Rat Muscarinic acetylcholine receptor M3
    Protein for Rat Muscarinic acetylcholine receptor M3
    Protein for Rat Muscarinic acetylcholine receptor M3
    Protein for Rat Muscarinic acetylcholine receptor M3
    Protein for Rat Muscarinic acetylcholine receptor M3
    Protein for Rat Muscarinic acetylcholine receptor M3
    Protein for Rat Muscarinic acetylcholine receptor M3

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    Precision
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    Linearity
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    References
    1. 1.
      "Identification of a family of muscarinic acetylcholine receptor genes."
      Bonner T.I. , Buckley N.J. , Young A.C. , Brann M.R.
      Science237:527-532(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    2. 2.
      "Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes."
      Bonner T.I. , Young A.C. , Brann M.R. , Buckley N.J.
      Neuron1:403-410(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 184
    3. 3.
      "A novel subtype of muscarinic receptor identified by homology screening."
      Braun T. , Schofield P.R. , Shivers B.D. , Pritchett D.B. , Seeburg P.H.
      Biochem. Biophys. Res. Commun.149:125-132(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Brain.
    4. 4.
      "Molecular cloning of m3 muscarinic acetylcholine receptor in rat iris."
      Furuta M. , Ohya S. , Imaizumi Y. , Watanabe M.
      J. Smooth Muscle Res.34:111-122(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Iris.
    5. 5.
      "Muscarinic acetylcholine receptors. Peptide sequencing identifies residues involved in antagonist binding and disulfide bond formation."
      Kurtenbach E. , Curtis C.A.M. , Pedder E.K. , Aitken A. , Harris A.C.M. , Hulme E.C.
      J. Biol. Chem.265:13702-13708(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 104-166
    6. 6.
      "Site-directed mutagenesis of the m3 muscarinic receptor: identification of a series of threonine and tyrosine residues involved in agonist but not antagonist binding."
      Wess J. , Gdula D. , Brann M.R.
      EMBO J.10:3729-3734(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF TYR-148; THR-231; THR-234; TYR-506; TYR-529 AND TYR-533;FUNCTION;SUBCELLULAR LOCATION
    7. 7.
      "Role of conserved threonine and tyrosine residues in acetylcholine binding and muscarinic receptor activation. A study with m3 muscarinic receptor point mutants."
      Wess J. , Maggio R. , Palmer J.R. , Vogel Z.
      J. Biol. Chem.267:19313-19319(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF THR-234 AND TYR-506;FUNCTION;SUBCELLULAR LOCATION
    8. 8.
      "Structure and dynamics of the M3 muscarinic acetylcholine receptor."
      Kruse A.C. , Hu J. , Pan A.C. , Arlow D.H. , Rosenbaum D.M. , Rosemond E. , Green H.F. , Liu T. , Chae P.S. , Dror R.O. , Shaw D.E. , Weis W.I. , Wess J. , Kobilka B.K.
      Nature482:552-556(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.40 ANGSTROMS) OF 57-589 IN COMPLEX WITH THE INVERSE AGONIST TIOTROPIUM;FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY;DISULFIDE BOND
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