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Index > Protein center > ACOT8(Gene name) > Human
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  • ACOT8 (Gene name),
  • Acyl-coenzyme A thioesterase 8 (Protein name ),  ACOT8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ACOT8(ACTEIII;PTE1;PTE2);
    Protein name:
    Acyl-coenzyme A thioesterase 8(Acyl-CoA thioesterase 8);
    Alternative:
    Choloyl-coenzyme A thioesterase;Acyl-CoA thioesterase 8;PTE-2(PTE-1);HIV-Nef-associated acyl-CoA thioesterase;Peroxisomal long-chain acyl-CoA thioesterase 1(hACTE-III);Peroxisomal acyl-coenzyme A thioester hydrolase 1(PTE-1);Thioesterase II(hACTE-III;hACTEIII;hTE);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with HIV-1 Nef.
    Function:
    Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH. May mediate Nef-induced down-regulation of CD4. Major thioesterase in peroxisomes. Competes with BAAT (Bile acid CoA: amino acid N-acyltransferase) for bile acid-CoA substrate (such as chenodeoxycholoyl-CoA). Shows a preference for medium-length fatty acyl-CoAs (By similarity). May be involved in the metabolic regulation of peroxisome proliferation.
    Subcellular Location:
    Peroxisome
    Protein Attributes:
    Sequence length:
    319
    Sequence:
    50:
    MSSPQAPEDG | QGCGDRGDPP | GDLRSVLVTT | VLNLEPLDED | LFRGRHYWVP | 
    100:
    AKRLFGGQIV | GQALVAAAKS | VSEDVHVHSL | HCYFVRAGDP | KLPVLYQVER | 
    150:
    TRTGSSFSVR | SVKAVQHGKP | IFICQASFQQ | AQPSPMQHQF | SMPTVPPPEE | 
    200:
    LLDCETLIDQ | YLRDPNLQKR | YPLALNRIAA | QEVPIEIKPV | NPSPLSQLQR | 
    250:
    MEPKQMFWVR | ARGYIGEGDM | KMHCCVAAYI | SDYAFLGTAL | LPHQWQHKVH | 
    300:
    FMVSLDHSMW | FHAPFRADHW | MLYECESPWA | GGSRGLVHGR | LWRQDGVLAV | 
    319:
    TCAQEGVIRV | KPQVSESKL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    UniGene:
    MIM:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Acyl-CoA thioesterase 8
    ELISA Kit for Human Acyl-CoA thioesterase 8
    ELISA Kit for Human Acyl-CoA thioesterase 8
    CLIA Kit for Human Acyl-CoA thioesterase 8
    CLIA Kit for Human Acyl-CoA thioesterase 8
    CLIA Kit for Human Acyl-CoA thioesterase 8
    Polyclonal Antibody for Human Acyl-CoA thioesterase 8
    Polyclonal Antibody for Human Acyl-CoA thioesterase 8
    Polyclonal Antibody for Human Acyl-CoA thioesterase 8
    Monoclonal Antibody for Human Acyl-CoA thioesterase 8
    Monoclonal Antibody for Human Acyl-CoA thioesterase 8
    Monoclonal Antibody for Human Acyl-CoA thioesterase 8
    Protein for Human Acyl-CoA thioesterase 8
    Protein for Human Acyl-CoA thioesterase 8
    Protein for Human Acyl-CoA thioesterase 8

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    Precision
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    Linearity
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    References
    1. 1.
      "A novel acyl-CoA thioesterase enhances its enzymatic activity by direct binding with HIV Nef."
      Watanabe H. , Shiratori T. , Shoji H. , Miyatake S. , Okazaki Y. , Ikuta K. , Sato T. , Saito T.
      Biochem. Biophys. Res. Commun.238:234-239(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH HIV-1 NEF;TISSUE SPECIFICITY
    2. 2.
      "Binding of HIV-1 Nef to a novel thioesterase enzyme correlates with Nef-mediated CD4 down-regulation."
      Liu L.X. , Margottin F. , Le Gall S. , Schwartz O. , Selig L. , Benarous R. , Benichou S.
      J. Biol. Chem.272:13779-13785(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Lymphoid tissue.
    3. 3.
      "Identification of peroxisomal acyl-CoA thioesterases in yeast and humans."
      Jones J.M. , Nau K. , Geraghty M.T. , Erdmann R. , Gould S.J.
      J. Biol. Chem.274:9216-9223(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Muscle.
    4. 4.
      "The DNA sequence and comparative analysis of human chromosome 20."
      Deloukas P. , Matthews L.H. , Ashurst J.L. , Burton J. , Gilbert J.G.R. , Jones M. , Stavrides G. , Almeida J.P. , Babbage A.K. , Bagguley C.L. , Bailey J. , Barlow K.F. , Bates K.N. , Beard L.M. , Beare D.M. , Beasley O.P. , Bird C.P. , Blakey S.E. , more...
      Nature414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    6. 6.
      "Overexpression of human acyl-CoA thioesterase upregulates peroxisome biogenesis."
      Ishizuka M. , Toyama Y. , Watanabe H. , Fujiki Y. , Takeuchi A. , Yamasaki S. , Yuasa S. , Miyazaki M. , Nakajima N. , Taki S. , Saito T.
      Exp. Cell Res.297:127-141(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "The role Acyl-CoA thioesterases play in mediating intracellular lipid metabolism."
      Hunt M.C. , Alexson S.E.H.
      Prog. Lipid Res.41:99-130(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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