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Index > Protein center > APEH(Gene name) > Human
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  • APEH (Gene name),
  • Acylamino-acid-releasing enzyme (Protein name ),  ACPH_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    APEH(D3F15S2;D3S48E;DNF15S2);
    Protein name:
    Acylamino-acid-releasing enzyme(AARE);
    Alternative:
    Oxidized protein hydrolase(OPH);Acyl-peptide hydrolase(APH);Acylaminoacyl-peptidase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer.
    Function:
    This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    732
    Sequence:
    50:
    MERQVLLSEP | EEAAALYRGL | SRQPALSAAC | LGPEVTTQYG | GQYRTVHTEW | 
    100:
    TQRDLERMEN | IRFCRQYLVF | HDGDSVVFAG | PAGNSVETRG | ELLSRESPSG | 
    150:
    TMKAVLRKAG | GTGPGEEKQF | LEVWEKNRKL | KSFNLSALEK | HGPVYEDDCF | 
    200:
    GCLSWSHSET | HLLYVAEKKR | PKAESFFQTK | ALDVSASDDE | IARLKKPDQA | 
    250:
    IKGDQFVFYE | DWGENMVSKS | IPVLCVLDVE | SGNISVLEGV | PENVSPGQAF | 
    300:
    WAPGDAGVVF | VGWWHEPFRL | GIRFCTNRRS | ALYYVDLIGG | KCELLSDDSL | 
    350:
    AVSSPRLSPD | QCRIVYLQYP | SLIPHHQCSQ | LCLYDWYTKV | TSVVVDVVPR | 
    400:
    QLGENFSGIY | CSLLPLGCWS | ADSQRVVFDS | AQRSRQDLFA | VDTQVGTVTS | 
    450:
    LTAGGSGGSW | KLLTIDQDLM | VAQFSTPSLP | PTLKVGFLPS | AGKEQSVLWV | 
    500:
    SLEEAEPIPD | IHWGIRVLQP | PPEQENVQYA | GLDFEAILLQ | PGSPPDKTQV | 
    550:
    PMVVMPHGGP | HSSFVTAWML | FPAMLCKMGF | AVLLVNYRGS | TGFGQDSILS | 
    600:
    LPGNVGHQDV | KDVQFAVEQV | LQEEHFDASH | VALMGGSHGG | FISCHLIGQY | 
    650:
    PETYRACVAR | NPVINIASML | GSTDIPDWCV | VEAGFPFSSD | CLPDLSVWAE | 
    700:
    MLDKSPIRYI | PQVKTPLLLM | LGQEDRRVPF | KQGMEYYRAL | KTRNVPVRLL | 
    732:
    LYPKSTHALS | EVEVESDSFM | NAVLWLRTHL | GS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    MIM:
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human AARE
    Cat.:
    E14162h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human AARE
    MSDS:
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    ELISA Kit for Human AARE
    MSDS:
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    ELISA Kit for Human AARE
    Cat.:
    E14162m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human AARE
    MSDS:
    Please sign in first.
    ELISA Kit for Human AARE
    MSDS:
    Please sign in first.
    CLIA Kit for Human AARE
    MSDS:
    Please sign in first.
    CLIA Kit for Human AARE
    MSDS:
    Please sign in first.
    CLIA Kit for Human AARE
    Cat.:
    U14162m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human AARE
    MSDS:
    Please sign in first.
    CLIA Kit for Human AARE
    MSDS:
    Please sign in first.
    CLIA Kit for Human AARE
    Cat.:
    U14162h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human AARE
    Polyclonal Antibody for Human AARE
    Polyclonal Antibody for Human AARE
    Polyclonal Antibody for Human AARE
    Polyclonal Antibody for Human AARE
    Polyclonal Antibody for Human AARE
    Monoclonal Antibody for Human AARE
    Monoclonal Antibody for Human AARE
    Monoclonal Antibody for Human AARE
    Monoclonal Antibody for Human AARE
    Monoclonal Antibody for Human AARE
    Monoclonal Antibody for Human AARE
    Protein for Human AARE
    Protein for Human AARE
    Protein for Human AARE
    Protein for Human AARE
    Protein for Human AARE
    Protein for Human AARE

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    References
    1. 1.
      "The nucleotide sequence of human acylamino acid-releasing enzyme."
      Mitta M. , Ohnogi H. , Mizutani S. , Sakiyama F. , Kato I. , Tsunasawa S.
      DNA Res.3:31-35(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      "Identification of oxidized protein hydrolase of human erythrocytes as acylpeptide hydrolase."
      Fujino T. , Watanabe K. , Beppu M. , Kikugawa K. , Yasuda H.
      Biochim. Biophys. Acta1478:102-112(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Muscle.
    4. 4.
      "The DNF15S2 locus at 3p21 is transcribed in normal lung and small cell lung cancer."
      Naylor S.L. , Marshall A. , Hensel C. , Martinez P.F. , Holley B. , Sakaguchi A.Y.
      Genomics4:355-361(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PRELIMINARY NUCLEOTIDE SEQUENCE OF 102-732
    5. 5.
      "Structural investigations on human erythrocyte acylpeptide hydrolase by mass spectrometric procedures."
      Scaloni A. , Ingallinella P. , Andolfo A. , Jones W. , Marino G. , Manning J.M.
      J. Protein Chem.18:349-360(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;MASS SPECTROMETRY;ACETYLATION AT MET-1
    6. 6.
      "The gene from the short arm of chromosome 3, at D3F15S2, frequently deleted in renal cell carcinoma, encodes acylpeptide hydrolase."
      Erlandsson R. , Boldog F. , Persson B. , Zabarovsky E.R. , Allikmets R.L. , Sumegi J. , Klein G. , Joernvall H.
      Oncogene6:1293-1295(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      "Genetic relationship between acylpeptide hydrolase and acylase, two hydrolytic enzymes with similar binding but different catalytic specificities."
      Jones W.M. , Scaloni A. , Bossa F. , Popowicz A.M. , Schneewind O. , Manning J.M.
      Proc. Natl. Acad. Sci. U.S.A.88:2194-2198(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    8. 8.
      "Acylpeptide hydrolase: inhibitors and some active site residues of the human enzyme."
      Scaloni A. , Jones W.M. , Barra D. , Pospischil M. , Sassa S. , Popowicz A. , Manning L.R. , Schneewind O. , Manning J.M.
      J. Biol. Chem.267:3811-3818(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACTIVE SITES SER-587 AND HIS-707
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-185 AND SER-187;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-187;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "Crystallization and preliminary X-ray studies of human erythrocyte acylpeptide hydrolase."
      Feese M. , Scaloni A. , Jones W.M. , Mannig J.M. , Remington S.J.
      J. Mol. Biol.233:546-549(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS)
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