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Index > Protein center > ADAM12(Gene name) > Human
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  • ADAM12 (Gene name),
  • Disintegrin and metalloproteinase domain-containing protein 12 (Protein name ),  ADA12_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ADAM12(UNQ346/PRO545;MLTN);
    Protein name:
    Disintegrin and metalloproteinase domain-containing protein 12(ADAM 12);
    Alternative:
    Meltrin-alpha;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A. Interacts with FST3. Interacts with GNB2L1/RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.
    Function:
    Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.
    Subcellular Location:
    Isoform 4 Secreted
    Protein Attributes:
    Sequence length:
    909
    Sequence:
    50:
    MAARPLPVSP | ARALLLALAG | ALLAPCEARG | VSLWNQGRAD | EVVSASVGSG | 
    100:
    DLWIPVKSFD | SKNHPEVLNI | RLQRESKELI | INLERNEGLI | ASSFTETHYL | 
    150:
    QDGTDVSLAR | NYTVILGHCY | YHGHVRGYSD | SAVSLSTCSG | LRGLIVFENE | 
    200:
    SYVLEPMKSA | TNRYKLFPAK | KLKSVRGSCG | SHHNTPNLAA | KNVFPPPSQT | 
    250:
    WARRHKRETL | KATKYVELVI | VADNREFQRQ | GKDLEKVKQR | LIEIANHVDK | 
    300:
    FYRPLNIRIV | LVGVEVWNDM | DKCSVSQDPF | TSLHEFLDWR | KMKLLPRKSH | 
    350:
    DNAQLVSGVY | FQGTTIGMAP | IMSMCTADQS | GGIVMDHSDN | PLGAAVTLAH | 
    400:
    ELGHNFGMNH | DTLDRGCSCQ | MAVEKGGCIM | NASTGYPFPM | VFSSCSRKDL | 
    450:
    ETSLEKGMGV | CLFNLPEVRE | SFGGQKCGNR | FVEEGEECDC | GEPEECMNRC | 
    500:
    CNATTCTLKP | DAVCAHGLCC | EDCQLKPAGT | ACRDSSNSCD | LPEFCTGASP | 
    550:
    HCPANVYLHD | GHSCQDVDGY | CYNGICQTHE | QQCVTLWGPG | AKPAPGICFE | 
    600:
    RVNSAGDPYG | NCGKVSKSSF | AKCEMRDAKC | GKIQCQGGAS | RPVIGTNAVS | 
    650:
    IETNIPLQQG | GRILCRGTHV | YLGDDMPDPG | LVLAGTKCAD | GKICLNRQCQ | 
    700:
    NISVFGVHEC | AMQCHGRGVC | NNRKNCHCEA | HWAPPFCDKF | GFGGSTDSGP | 
    750:
    IRQADNQGLT | IGILVTILCL | LAAGFVVYLK | RKTLIRLLFT | NKKTTIEKLR | 
    800:
    CVRPSRPPRG | FQPCQAHLGH | LGKGLMRKPP | DSYPPKDNPR | RLLQCQNVDI | 
    850:
    SRPLNGLNVP | QPQSTQRVLP | PLHRAPRAPS | VPARPLPAKP | ALRQAQGTCK | 
    900:
    PNPPQKPLPA | DPLARTTRLT | HALARTPGQW | ETGLRLAPLR | PAPQYPHQVP | 
    909:
    RSTHTAYIK
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    String:
    UniGene:
    MIM:
    UniGene:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human ADAM 12
    Cat.:
    E14640h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human ADAM 12
    Cat.:
    E14640m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human ADAM 12
    Cat.:
    U14640h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human ADAM 12
    Cat.:
    U14640m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human ADAM 12
    Polyclonal Antibody for Human ADAM 12
    Monoclonal Antibody for Human ADAM 12
    Monoclonal Antibody for Human ADAM 12
    Protein for Human ADAM 12
    Protein for Human ADAM 12

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo."
      Gilpin B.J. , Loechel F. , Mattei M.-G. , Engvall E. , Albrechtsen R. , Wewer U.M.
      J. Biol. Chem.273:157-166(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANT ARG-48
      tissue: Placenta.
    2. 2.
      Gilpin B.J. , Loechel F. , Mattei M.-G. , Engvall E. , Albrechtsen R. , Wewer U.M.
      Submitted (2001-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 36
    3. 3.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ARG-48
    4. 4.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-48
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANT ARG-48
      tissue: Placenta.
    7. 7.
      "Human ADAM 12 (meltrin alpha) is an active metalloprotease."
      Loechel F. , Gilpin B.J. , Engvall E. , Albrechtsen R. , Wewer U.M.
      J. Biol. Chem.273:16993-16997(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    8. 8.
      "The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading."
      Iba K. , Albrechtsen R. , Gilpin B.J. , Froehlich C. , Loechel F. , Zolkiewska A. , Ishiguro K. , Kojima T. , Liu W. , Langford J.K. , Sanderson R.D. , Brakebusch C. , Faessler R. , Wewer U.M.
      J. Cell Biol.149:1143-1156(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYNDECANS
    9. 9.
      "The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells."
      Abram C.L. , Seals D.F. , Pass I. , Salinsky D. , Maurer L. , Roth T.M. , Courtneidge S.A.
      J. Biol. Chem.278:16844-16851(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH3PXD2A
    10. 10.
      "FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation."
      Bartholin L. , Destaing O. , Forissier S. , Martel S. , Maguer-Satta V. , Jurdic P. , Rimokh R.
      Biol. Cell97:577-588(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FST3
    11. 11.
      "RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis."
      Bourd-Boittin K. , Le Pabic H. , Bonnier D. , L'Helgoualc'h A. , Theret N.
      J. Biol. Chem.283:26000-26009(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GNB2L1
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-301; GLU-479 AND PHE-792
    13. 13.
      "Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
      Wei X. , Moncada-Pazos A. , Cal S. , Soria-Valles C. , Gartner J. , Rudloff U. , Lin J.C. , Rosenberg S.A. , Lopez-Otin C. , Samuels Y.
      Hum. Mutat.32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLU-712 AND SER-893
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