ADAM12 ELISA Kit for Human(Homo sapiens) | EIAab.comADAM12 ELISA Kit for Human(Homo sapiens)

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ADAM12 (Gene name),

Disintegrin and metalloproteinase domain-containing protein 12 (Protein name ), ADA12_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ADAM12(UNQ346/PRO545;MLTN);

Protein name:

Disintegrin and metalloproteinase domain-containing protein 12(ADAM 12);

Alternative:

Meltrin-alpha;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A. Interacts with FST3. Interacts with GNB2L1/RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.

Function:

Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors.

Subcellular Location:

Isoform 4 Secreted

Protein Attributes:

Sequence length:

909

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

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650:

700:

750:

800:

850:

900:

909:

RSTHTAYIK

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

O43184

KEGG:

hsa:8038

UniGene:

Hs.594351

STRING:

9606.ENSP00000357668

MIM:

602714

UniGene:

Hs.594537

Pfam:

PF08516

String:

O43184

Uniprot:

O43184

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ELISA Kit for Human ADAM 12

Cat.:

E14640h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human ADAM 12

Cat.:

E14640m

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MSDS:

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Packing:

96T

CLIA Kit for Human ADAM 12

Cat.:

U14640h

Price:

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human ADAM 12

Cat.:

U14640m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human ADAM 12

Monoclonal Antibody for Human ADAM 12

Protein for Human ADAM 12

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo."
Gilpin B.J. , Loechel F. , Mattei M.-G. , Engvall E. , Albrechtsen R. , Wewer U.M.
J. Biol. Chem.273:157-166(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);VARIANT ARG-48
tissue: Placenta.
2.

Gilpin B.J. , Loechel F. , Mattei M.-G. , Engvall E. , Albrechtsen R. , Wewer U.M.
Submitted (2001-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 36
3.

"The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);VARIANT ARG-48
4.

"The DNA sequence and comparative analysis of human chromosome 10."
Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-48
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4);VARIANT ARG-48
tissue: Placenta.
7.

"Human ADAM 12 (meltrin alpha) is an active metalloprotease."
Loechel F. , Gilpin B.J. , Engvall E. , Albrechtsen R. , Wewer U.M.
J. Biol. Chem.273:16993-16997(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
8.

"The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading."
Iba K. , Albrechtsen R. , Gilpin B.J. , Froehlich C. , Loechel F. , Zolkiewska A. , Ishiguro K. , Kojima T. , Liu W. , Langford J.K. , Sanderson R.D. , Brakebusch C. , Faessler R. , Wewer U.M.
J. Cell Biol.149:1143-1156(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYNDECANS
9.

"The adaptor protein fish associates with members of the ADAMs family and localizes to podosomes of Src-transformed cells."
Abram C.L. , Seals D.F. , Pass I. , Salinsky D. , Maurer L. , Roth T.M. , Courtneidge S.A.
J. Biol. Chem.278:16844-16851(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SH3PXD2A
10.

"FLRG, a new ADAM12-associated protein, modulates osteoclast differentiation."
Bartholin L. , Destaing O. , Forissier S. , Martel S. , Maguer-Satta V. , Jurdic P. , Rimokh R.
Biol. Cell97:577-588(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FST3
11.

"RACK1, a new ADAM12 interacting protein. Contribution to liver fibrogenesis."
Bourd-Boittin K. , Le Pabic H. , Bonnier D. , L'Helgoualc'h A. , Theret N.
J. Biol. Chem.283:26000-26009(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GNB2L1
12.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] HIS-301; GLU-479 AND PHE-792
13.

"Analysis of the disintegrin-metalloproteinases family reveals ADAM29 and ADAM7 are often mutated in melanoma."
Wei X. , Moncada-Pazos A. , Cal S. , Soria-Valles C. , Gartner J. , Rudloff U. , Lin J.C. , Rosenberg S.A. , Lopez-Otin C. , Samuels Y.
Hum. Mutat.32:E2148-E2175(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GLU-712 AND SER-893

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