Gene name:
ADAM17 (CSVP;TACE) ;
Protein name:
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) ;
Alternative:
TNF-alpha convertase ;Snake venom-like protease ;TNF-alpha-converting enzyme ;
CD:
CD156b ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with MAD2L1 and MUC1.
Function:
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MRQSLLFLTS | VVPFVLAPRP | PDDPGFGPHQ | RLEKLDSLLS | DYDILSLSNI |
100:
QQHSVRKRDL | QTSTHVETLL | TFSALKRHFK | LYLTSSTERF | SQNFKVVVVD |
150:
GKNESEYTVK | WQDFFTGHVV | GEPDSRVLAH | IRDDDVIIRI | NTDGAEYNIE |
200:
PLWRFVNDTK | DKRMLVYKSE | DIKNVSRLQS | PKVCGYLKVD | NEELLPKGLV |
250:
DREPPEELVH | RVKRRADPDP | MKNTCKLLVV | ADHRFYRYMG | RGEESTTTNY |
300:
LIELIDRVDD | IYRNTSWDNA | GFKGYGIQIE | QIRILKSPQE | VKPGEKHYNM |
350:
AKSYPNEEKD | AWDVKMLLEQ | FSFDIAEEAS | KVCLAHLFTY | QDFDMGTLGL |
400:
AYVGSPRANS | HGGVCPKAYY | SPVGKKNIYL | NSGLTSTKNY | GKTILTKEAD |
450:
LVTTHELGHN | FGAEHDPDGL | AECAPNEDQG | GKYVMYPIAV | SGDHENNKMF |
500:
SNCSKQSIYK | TIESKAQECF | QERSNKVCGN | SRVDEGEECD | PGIMYLNNDT |
550:
CCNSDCTLKE | GVQCSDRNSP | CCKNCQFETA | QKKCQEAINA | TCKGVSYCTG |
600:
NSSECPPPGN | AEDDTVCLDL | GKCKDGKCIP | FCEREQQLES | CACNETDNSC |
650:
KVCCRDLSGR | CVPYVDAEQK | NLFLRKGKPC | TVGFCDMNGK | CEKRVQDVIE |
700:
RFWDFIDQLS | INTFGKFLAD | NIVGSVLVFS | LIFWIPFSIL | VHCVDKKLDK |
750:
QYESLSLFHP | SNVEMLSSMD | SASVRIIKPF | PAPQTPGRLQ | PAPVIPSAPA |
800:
APKLDHQRMD | TIQEDPSTDS | HMDEDGFEKD | PFPNSSTAAK | SFEDLTDHPV |
824:
TRSEKAASFK | LQRQNRVDSK | ETEC
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Mouse
Rat
ELISA Kit for Human ADAM 17
ELISA Kit for Human ADAM 17
ELISA Kit for Human ADAM 17
ELISA Kit for Human ADAM 17
CLIA Kit for Human ADAM 17
CLIA Kit for Human ADAM 17
CLIA Kit for Human ADAM 17
CLIA Kit for Human ADAM 17
Polyclonal Antibody for Human ADAM 17
Polyclonal Antibody for Human ADAM 17
Polyclonal Antibody for Human ADAM 17
Polyclonal Antibody for Human ADAM 17
Monoclonal Antibody for Human ADAM 17
Monoclonal Antibody for Human ADAM 17
Monoclonal Antibody for Human ADAM 17
Monoclonal Antibody for Human ADAM 17
Protein for Human ADAM 17
Protein for Human ADAM 17
Protein for Human ADAM 17
Protein for Human ADAM 17
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Wang Z L, Gao S, Li L, et al
References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A);PARTIAL PROTEIN SEQUENCE
tissue :
Leukocyte .
tissue :
Monocyte .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A)
tissue :
Cartilage .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-735
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MUC1;FUNCTION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-819
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-791;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-791;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT THR-735;INTERACTION WITH MAPK14
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Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-791;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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Cited for : X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 219-473;ACTIVE SITE