Protein name:
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM 17) ;
Alternative:
TNF-alpha-converting enzyme ;TNF-alpha convertase ;
CD:
CD156b ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with MAD2L1 and MUC1.
Function:
Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
Subcellular Location:
Isoform Short
Secreted
Protein Attributes:
50:
MRRRLLILTT | LVPFVLAPRP | PEEAGSGSHP | RLEKLDSLLS | DYDILSLANI |
100:
QQHSIRKRDL | QSATHLETLL | TFSALKRHFK | LYLTSSTERF | SQNLRVVVVD |
150:
GKEESEYSVK | WQNFFSGHVV | GEPDSRVLAH | IGDDDVTVRI | NTDGAEYNVE |
200:
PLWRFVNDTK | DKRMLVYKSE | DIKDFSRLQS | PKVCGYLNAD | SEELLPKGLI |
250:
DREPSEEFVR | RVKRRAEPNP | LKNTCKLLVV | ADHRFYKYMG | RGEESTTTNY |
300:
LIELIDRVDD | IYRNTSWDNA | GFKGYGVQIE | QIRILKSPQE | VKPGERHFNM |
350:
AKSFPNEEKD | AWDVKMLLEQ | FSFDIAEEAS | KVCLAHLFTY | QDFDMGTLGL |
400:
AYVGSPRANS | HGGVCPKAYY | NPTVKKNIYL | NSGLTSTKNY | GKTILTKEAD |
450:
LVTTHELGHN | FGAEHDPDGL | AECAPNEDQG | GKYVMYPIAV | SGDHENNKMF |
500:
SNCSKQSIYK | TIESKAQECF | QERSNKVCGN | SRVDEGEECD | PGIMYLNNDT |
550:
CCNSDCTLKP | GVQCSDRNSP | CCKNCQFETA | QKKCQEAINA | TCKGVSYCTG |
600:
NSSECPPPGD | AEDDTVCLDL | GKCKAGKCIP | FCKREQELES | CACVDTDNSC |
650:
KVCCRNLSGP | CVPYVDAEQK | NLFLRKGKPC | TVGFCDMNGK | CEKRVQDVIE |
700:
RFWDFIDQLS | INTFGKFLAD | NIVGSVLVFS | LIFWIPFSIL | VHCVDKKLDK |
750:
QYESLSLFHH | SNIEMLSSMD | SASVRIIKPF | PAPQTPGRLQ | ALQPAAMMPP |
800:
VPAAPKLDHQ | RMDTIQEDPS | TDSHADDDGF | EKDPFPNSST | AAKSFEDLTD |
827:
HPVTRSEKAA | SFKLQRQSRV | DSKETEC
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Pig
Mouse
Rat
ELISA Kit for Mouse ADAM 17
ELISA Kit for Mouse ADAM 17
ELISA Kit for Mouse ADAM 17
ELISA Kit for Mouse ADAM 17
CLIA Kit for Mouse ADAM 17
CLIA Kit for Mouse ADAM 17
CLIA Kit for Mouse ADAM 17
CLIA Kit for Mouse ADAM 17
Polyclonal Antibody for Mouse ADAM 17
Polyclonal Antibody for Mouse ADAM 17
Polyclonal Antibody for Mouse ADAM 17
Polyclonal Antibody for Mouse ADAM 17
Monoclonal Antibody for Mouse ADAM 17
Monoclonal Antibody for Mouse ADAM 17
Monoclonal Antibody for Mouse ADAM 17
Monoclonal Antibody for Mouse ADAM 17
Protein for Mouse ADAM 17
Protein for Mouse ADAM 17
Protein for Mouse ADAM 17
Protein for Mouse ADAM 17
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT)
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"TNF-alpha converting enzyme (TACE) is inhibited by TIMP-3."
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PubMed ]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
4.
"Isolation of murine TNF-alpha converting enzyme."
Cerretti D.P.
Submitted (1996-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
strain :
C57BL/6J .
tissue :
Brain cortex .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
strain :
C57BL/6 .
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN PROCESSING OF GROWTH HORMONE RECEPTOR
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-794;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]