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Index > Protein center > Adam17(Gene name) > Mouse
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  • Adam17 (Gene name),
  • Disintegrin and metalloproteinase domain-containing protein 17 (Protein name ),  ADA17_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Adam17(Tace);
    Protein name:
    Disintegrin and metalloproteinase domain-containing protein 17(ADAM 17);
    Alternative:
    TNF-alpha-converting enzyme;TNF-alpha convertase;
    CD:
    CD156b;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with MAD2L1 and MUC1.
    Function:
    Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Also involved in the activation of Notch pathway.
    Subcellular Location:
    Isoform Short Secreted
    Protein Attributes:
    Sequence length:
    827
    Sequence:
    50:
    MRRRLLILTT | LVPFVLAPRP | PEEAGSGSHP | RLEKLDSLLS | DYDILSLANI | 
    100:
    QQHSIRKRDL | QSATHLETLL | TFSALKRHFK | LYLTSSTERF | SQNLRVVVVD | 
    150:
    GKEESEYSVK | WQNFFSGHVV | GEPDSRVLAH | IGDDDVTVRI | NTDGAEYNVE | 
    200:
    PLWRFVNDTK | DKRMLVYKSE | DIKDFSRLQS | PKVCGYLNAD | SEELLPKGLI | 
    250:
    DREPSEEFVR | RVKRRAEPNP | LKNTCKLLVV | ADHRFYKYMG | RGEESTTTNY | 
    300:
    LIELIDRVDD | IYRNTSWDNA | GFKGYGVQIE | QIRILKSPQE | VKPGERHFNM | 
    350:
    AKSFPNEEKD | AWDVKMLLEQ | FSFDIAEEAS | KVCLAHLFTY | QDFDMGTLGL | 
    400:
    AYVGSPRANS | HGGVCPKAYY | NPTVKKNIYL | NSGLTSTKNY | GKTILTKEAD | 
    450:
    LVTTHELGHN | FGAEHDPDGL | AECAPNEDQG | GKYVMYPIAV | SGDHENNKMF | 
    500:
    SNCSKQSIYK | TIESKAQECF | QERSNKVCGN | SRVDEGEECD | PGIMYLNNDT | 
    550:
    CCNSDCTLKP | GVQCSDRNSP | CCKNCQFETA | QKKCQEAINA | TCKGVSYCTG | 
    600:
    NSSECPPPGD | AEDDTVCLDL | GKCKAGKCIP | FCKREQELES | CACVDTDNSC | 
    650:
    KVCCRNLSGP | CVPYVDAEQK | NLFLRKGKPC | TVGFCDMNGK | CEKRVQDVIE | 
    700:
    RFWDFIDQLS | INTFGKFLAD | NIVGSVLVFS | LIFWIPFSIL | VHCVDKKLDK | 
    750:
    QYESLSLFHH | SNIEMLSSMD | SASVRIIKPF | PAPQTPGRLQ | ALQPAAMMPP | 
    800:
    VPAAPKLDHQ | RMDTIQEDPS | TDSHADDDGF | EKDPFPNSST | AAKSFEDLTD | 
    827:
    HPVTRSEKAA | SFKLQRQSRV | DSKETEC
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse ADAM 17
    Cat.:
    E1319h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse ADAM 17
    Cat.:
    E1319p
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    Please sign in first.
    MSDS:
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    Packing:
    96T
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    ELISA Kit for Mouse ADAM 17
    Cat.:
    E1319m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Mouse ADAM 17
    Cat.:
    E1319r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse ADAM 17
    Cat.:
    U1319r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse ADAM 17
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse ADAM 17
    Cat.:
    U1319h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Mouse ADAM 17
    Cat.:
    U1319m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse ADAM 17
    Cat.:
    P1319Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse ADAM 17
    Cat.:
    P1319Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse ADAM 17
    Polyclonal Antibody for Mouse ADAM 17
    Cat.:
    P1319Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse ADAM 17
    Monoclonal Antibody for Mouse ADAM 17
    Monoclonal Antibody for Mouse ADAM 17
    Monoclonal Antibody for Mouse ADAM 17
    Protein for Mouse ADAM 17
    Protein for Mouse ADAM 17
    Protein for Mouse ADAM 17
    Protein for Mouse ADAM 17

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    Linearity
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    References
    1. 1.
      "Characterization of the cDNA and gene for mouse tumour necrosis factor alpha converting enzyme (TACE/ADAM17) and its location to mouse chromosome 12 and human chromosome 2p25."
      Cerretti D.P. , Poindexter K. , Castner B.J. , Means G. , Copeland N.G. , Gilbert D.J. , Jenkins N.A. , Black R.A. , Nelson N.
      Cytokine11:541-551(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT)
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
    3. 3.
      "cDNA cloning of mouse tumor necrosis factor-alpha converting enzyme (TACE) and partial analysis of its promoter."
      Mizui Y. , Yamazaki K. , Sagane K. , Tanaka I.
      Gene233:67-74(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
    4. 4.
      "Isolation of murine TNF-alpha converting enzyme."
      Cerretti D.P.
      Submitted (1996-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      strain: C57BL/6J.
      tissue: Brain cortex.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      strain: C57BL/6.
      tissue: Brain.
    7. 7.
      "Tumor necrosis factor-alpha converting enzyme (TACE) is a growth hormone binding protein (GHBP) sheddase: the metalloprotease TACE/ADAM-17 is critical for (PMA-induced) GH receptor proteolysis and GHBP generation."
      Zhang Y. , Jiang J. , Black R.A. , Baumann G. , Frank S.J.
      Endocrinology141:4342-4348(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PROCESSING OF GROWTH HORMONE RECEPTOR
    8. 8.
      "Functional analysis of the domain structure of tumor necrosis factor-alpha converting enzyme."
      Reddy P. , Slack J.L. , Davis R. , Cerretti D.P. , Kozlosky C.J. , Blanton R.A. , Shows D. , Peschon J.J. , Black R.A.
      J. Biol. Chem.275:14608-14614(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      "A novel proteolytic cleavage involved in Notch signaling: the role of the disintegrin-metalloprotease TACE."
      Brou C. , Logeat F. , Gupta N. , Bessia C. , LeBail O. , Doedens J.R. , Cumano A. , Roux P. , Black R.A. , Israel A.
      Mol. Cell5:207-216(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "The phagosomal proteome in interferon-gamma-activated macrophages."
      Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
      Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-794;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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