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Index > Protein center > ADAP1(Gene name) > Human
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  • ADAP1 (Gene name),
  • Arf-GAP with dual PH domain-containing protein 1 (Protein name ),  ADAP1_HUMAN from NCBI database.
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    • Gene name:
    ADAP1(CENTA1);
    Protein name:
    Arf-GAP with dual PH domain-containing protein 1;
    Alternative:
    Putative MAPK-activating protein PM25;Centaurin-alpha-1(Cnt-a1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PRKCA, PRKCI and PRKCZ. Interacts with the N-terminal region of PRKD1.
    Function:
    GTPase-activating protein for the ADP ribosylation factor family (Probable). Binds phosphatidylinositol 3,4,5-trisphosphate (PtdInsP3) and inositol 1,3,4,5-tetrakisphosphate (InsP4).
    Subcellular Location:
    Nucleus Cytoplasm Recruited to the plasma membrane upon epidermal growth factor-dependent activation of phosphatidylinositol 4,5-diphosphate (PtdInsP2) 3-kinase.
    Protein Attributes:
    Sequence length:
    374
    Sequence:
    50:
    MAKERRRAVL | ELLQRPGNAR | CADCGAPDPD | WASYTLGVFI | CLSCSGIHRN | 
    100:
    IPQVSKVKSV | RLDAWEEAQV | EFMASHGNDA | ARARFESKVP | SFYYRPTPSD | 
    150:
    CQLLREQWIR | AKYERQEFIY | PEKQEPYSAG | YREGFLWKRG | RDNGQFLSRK | 
    200:
    FVLTEREGAL | KYFNRNDAKE | PKAVMKIEHL | NATFQPAKIG | HPHGLQVTYL | 
    250:
    KDNSTRNIFI | YHEDGKEIVD | WFNALRAARF | HYLQVAFPGA | GDADLVPKLS | 
    300:
    RNYLKEGYME | KTGPKQTEGF | RKRWFTMDDR | RLMYFKDPLD | AFARGEVFIG | 
    350:
    SKESGYTVLH | GFPPSTQGHH | WPHGITIVTP | DRKFLFACET | ESDQREWVAA | 
    374:
    FQKAVDRPML | PQEYAVEAHF | KHKP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    O75689
    String:
    O75689
    Pfam:
    PF01412
    UniGene:
    Hs.602573
    KEGG:
    hsa:11033
    MIM:
    608114
    STRING:
    9606.ENSP00000265846
    Uniprot:
    O75689
     
    FOR
    ELISA Kit for Human Arf-GAP with dual PH domain-containing protein 1
    CLIA Kit for Human Arf-GAP with dual PH domain-containing protein 1
    Polyclonal Antibody for Human Arf-GAP with dual PH domain-containing protein 1
    Monoclonal Antibody for Human Arf-GAP with dual PH domain-containing protein 1
    Protein for Human Arf-GAP with dual PH domain-containing protein 1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    Recovery
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Molecular cloning and functional characterization of a human homologue of centaurin-alpha."
      Venkateswarlu K. , Cullen P.J.
      Biochem. Biophys. Res. Commun.262:237-244(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF ARG-149 AND ARG-273
      tissue: Blood.
    2. 2.
      "Identification of centaurin-alpha1 as a potential in vivo phosphatidylinositol 3,4,5-trisphosphate-binding protein that is functionally homologous to the yeast ADP-ribosylation factor (ARF) GTPase-activating protein, Gcs1."
      Venkateswarlu K. , Oatey P.B. , Tavare J.M. , Jackson T.R. , Cullen P.J.
      Biochem. J.340:359-363(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF CYS-21; CYS-24; ARG-149 AND ARG-273;VARIANT SER-241
      tissue: Peripheral blood.
    3. 3.
      "Molecular identification of a high-affinity Ins(1,3,4,5)tetrakisphosphate/phosphatidylinositol(3,4, 5)trisphosphate binding protein from human brain, p42IP4."
      Horstmeyer A. , Reiser G.
      Submitted (1998-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT SER-241
      tissue: Brain.
    4. 4.
      "Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways."
      Matsuda A. , Suzuki Y. , Honda G. , Muramatsu S. , Matsuzaki O. , Nagano Y. , Doi T. , Shimotohno K. , Harada T. , Nishida E. , Hayashi H. , Sugano S.
      Oncogene22:3307-3318(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-241
      tissue: Lung fibroblast.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Small intestine.
    6. 6.
      "Human chromosome 7: DNA sequence and biology."
      Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
      Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT SER-241
      tissue: Brain.
    9. 9.
      "Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C."
      Zemlickova E. , Dubois T. , Kerai P. , Clokie S. , Cronshaw A.D. , Wakefield R.I.D. , Johannes F.-J. , Aitken A.
      Biochem. Biophys. Res. Commun.307:459-465(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRKCA; PRKCI; PRKCZ AND PRKD1;PHOSPHORYLATION AT SER-87 AND THR-276
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-272;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Crystal structure of full length centaurin alpha-1."
      Structural genomics consortium (SGC)
      Submitted (2008-12) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 3-370
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