ADA ELISA Kit for Bovine(Bos taurus) | EIAab.comADA ELISA Kit for Bovine(Bos taurus)

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ADA (Gene name),

Adenosine deaminase (Protein name ), ADA_BOVIN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ADA;

Protein name:

Adenosine deaminase;

Alternative:

Adenosine aminohydrolase;

Organism:

Bovine (Bos taurus).

General Annotation

Sub Unit:

Interacts with DPP4 (extracellular domain).

Function:

Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.

Subcellular Location:

Cell membrane Peripheral membrane protein Extracellular side Cell junction Cytoplasmic vesicle lumen Cytoplasm Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion.

Protein Attributes:

Sequence length:

363

Sequence:

50:

100:

150:

200:

250:

300:

350:

363:

YGMPSPASAE | QCL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9913.ENSBTAP00000006947

Pfam:

PF00962

UniGene:

Bt.4303

SMR:

P56658

String:

P56658

KEGG:

bta:280712

Uniprot:

P56658

FOR

ELISA Kit for Bovine Adenosine deaminase

Cat.:

E1390h

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96T

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ELISA Kit for Bovine Adenosine deaminase

Cat.:

E1390b

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96T

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ELISA Kit for Bovine Adenosine deaminase

Cat.:

E1390r

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96T

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ELISA Kit for Bovine Adenosine deaminase

Cat.:

E1390m

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Looking for manual.

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96T

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ELISA Kit for Bovine Adenosine deaminase

Cat.:

E1390c

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96T

CLIA Kit for Bovine Adenosine deaminase

Cat.:

U1390h

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96T

CLIA Kit for Bovine Adenosine deaminase

Cat.:

U1390r

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MSDS:

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Packing:

96T

CLIA Kit for Bovine Adenosine deaminase

Cat.:

U1390b

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Bovine Adenosine deaminase

Cat.:

U1390m

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Bovine Adenosine deaminase

Cat.:

U1390c

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Packing:

96T

Polyclonal Antibody for Bovine Adenosine deaminase

Cat.:

P1390Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine Adenosine deaminase

Cat.:

P1390Rb-m

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40ug/0.2ml

Polyclonal Antibody for Bovine Adenosine deaminase

Cat.:

P1390Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Bovine Adenosine deaminase

Monoclonal Antibody for Bovine Adenosine deaminase

Protein for Bovine Adenosine deaminase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The binding site of human adenosine deaminase for CD26/dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to CD26 but does not cause immune deficiency."
Richard E. , Arredondo-Vega F.X. , Santisteban I. , Kelly S.J. , Patel D.D. , Hershfield M.S.
J. Exp. Med.192:1223-1236(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Primary structure of bovine adenosine deaminase."
Kelly M.A. , Vestling M.M. , Murphy C.M. , Hua S. , Sumpter T. , Fenselau C.
J. Pharm. Biomed. Anal.14:1513-1519(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-357;MASS SPECTROMETRY
3.

"Structure of bovine adenosine deaminase complexed with 6-hydroxy-1,6-dihydropurine riboside."
Kinoshita T. , Nishio N. , Nakanishi I. , Sato A. , Fujii T.
Acta Crystallogr. D59:299-303(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-356 IN COMPLEX WITH ZINC IONS AND TRANSITION STATE ANALOG 6-HYDROXY-1,6-DIHYDROPURINE RIBOSIDE
4.

"A highly potent non-nucleoside adenosine deaminase inhibitor: efficient drug discovery by intentional lead hybridization."
Terasaka T. , Kinoshita T. , Kuno M. , Nakanishi I.
J. Am. Chem. Soc.126:34-35(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.00 ANGSTROMS) OF 2-356 IN COMPLEX WITH INHIBITOR AND ZINC IONS
5.

"Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface."
Weihofen W.A. , Liu J. , Reutter W. , Saenger W. , Fan H.
J. Biol. Chem.279:43330-43335(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.03 ANGSTROMS) OF 1-357 IN COMPLEX WITH ZINC IONS AND DPP4;SUBUNIT
6.

"Structure-based design and synthesis of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors."
Terasaka T. , Okumura H. , Tsuji K. , Kato T. , Nakanishi I. , Kinoshita T. , Kato Y. , Kuno M. , Seki N. , Naoe Y. , Inoue T. , Tanaka K. , Nakamura K.
J. Med. Chem.47:2728-2731(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.50 ANGSTROMS) OF 2-356 IN COMPLEX WITH INHIBITOR
7.

"Structure-based design, synthesis, and structure-activity relationship studies of novel non-nucleoside adenosine deaminase inhibitors."
Terasaka T. , Kinoshita T. , Kuno M. , Seki N. , Tanaka K. , Nakanishi I.
J. Med. Chem.47:3730-3743(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.25 ANGSTROMS) OF 2-356 IN COMPLEX WITH INHIBITOR
8.

"Structural basis of compound recognition by adenosine deaminase."
Kinoshita T. , Nakanishi I. , Terasaka T. , Kuno M. , Seki N. , Warizaya M. , Matsumura H. , Inoue T. , Takano K. , Adachi H. , Mori Y. , Fujii T.
Biochemistry44:10562-10569(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 2-356 IN COMPLEX WITH INHIBITOR
9.

"Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26)."
Weihofen W.A. , Liu J. , Reutter W. , Saenger W. , Fan H.
J. Biol. Chem.280:14911-14917(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.15 ANGSTROMS) OF 2-362 IN COMPLEX WITH DPP4 AND A HIV-1 TAT PEPTIDE
10.

"Rational design of non-nucleoside, potent, and orally bioavailable adenosine deaminase inhibitors: predicting enzyme conformational change and metabolism."
Terasaka T. , Tsuji K. , Kato T. , Nakanishi I. , Kinoshita T. , Kato Y. , Kuno M. , Inoue T. , Tanaka K. , Nakamura K.
J. Med. Chem.48:4750-4753(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 2-356 IN COMPLEX WITH INHIBITOR AND ZINC IONS
11.

"Conformational change of adenosine deaminase during ligand-exchange in a crystal."
Kinoshita T. , Tada T. , Nakanishi I.
Biochem. Biophys. Res. Commun.373:53-57(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.52 ANGSTROMS) OF 2-357 IN COMPLEX WITH EHNA

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