Adenosine deaminase (Protein name
), ADA_RAT from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
Ada;
Protein name:
Adenosine deaminase;
Alternative:
Adenosine aminohydrolase;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with DPP4 (extracellular domain).
Function:
Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine. Plays an important role in purine metabolism and in adenosine homeostasis. Modulates signaling by extracellular adenosine, and so contributes indirectly to cellular signaling events. Acts as a positive regulator of T-cell coactivation, by binding DPP4. Its interaction with DPP4 regulates lymphocyte-epithelial cell adhesion.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Extracellular side
Cell junction
Cytoplasmic vesicle lumen
Cytoplasm
Colocalized with DPP4 at the cell junction in lymphocyte-epithelial cell adhesion.
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Precision
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Recovery
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Linearity
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References
1.
"Restricted expression of adenosine deaminase in rat leptomeninges and its role in the regulation of sleep." Okada T.
,
Mochizuki T.
,
Huag Z.
,
Sugita Y.
,
Urade Y.
,
Hayaishi O.
Submitted (2001-04) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: NUCLEOTIDE SEQUENCE [MRNA]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for: CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY