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Index > Protein center > ADCY10(Gene name) > Human
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  • ADCY10 (Gene name),
  • Adenylate cyclase type 10 (Protein name ),  ADCYA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    ADCY10(SAC);
    Protein name:
    Adenylate cyclase type 10;
    Alternative:
    Adenylate cyclase homolog;AH-related protein;Testicular soluble adenylyl cyclase;Germ cell soluble adenylyl cyclase(hsAC;sAC);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor. Involved in ciliary beat regulation.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Cytoplasm perinuclear region Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.
    Protein Attributes:
    Sequence length:
    1610
    Sequence:
    50:
    MNTPKEEFQD | WPIVRIAAHL | PDLIVYGHFS | PERPFMDYFD | GVLMFVDISG | 
    100:
    FTAMTEKFSS | AMYMDRGAEQ | LVEILNYHIS | AIVEKVLIFG | GDILKFAGDA | 
    150:
    LLALWRVERK | QLKNIITVVI | KCSLEIHGLF | ETQEWEEGLD | IRVKIGLAAG | 
    200:
    HISMLVFGDE | THSHFLVIGQ | AVDDVRLAQN | MAQMNDVILS | PNCWQLCDRS | 
    250:
    MIEIESVPDQ | RAVKVNFLKP | PPNFNFDEFF | TKCTTFMHYY | PSGEHKNLLR | 
    300:
    LACTLKPDPE | LEMSLQKYVM | ESILKQIDNK | QLQGYLSELR | PVTIVFVNLM | 
    350:
    FEDQDKAEEI | GPAIQDAYMH | ITSVLKIFQG | QINKVFMFDK | GCSFLCVFGF | 
    400:
    PGEKVPDELT | HALECAMDIF | DFCSQVHKIQ | TVSIGVASGI | VFCGIVGHTV | 
    450:
    RHEYTVIGQK | VNLAARMMMY | YPGIVTCDSV | TYNGSNLPAY | FFKELPKKVM | 
    500:
    KGVADSGPLY | QYWGRTEKVM | FGMACLICNR | KEDYPLLGRN | KEINYFMYTM | 
    550:
    KKFLISNSSQ | VLMYEGLPGY | GKSQILMKIE | YLAQGKNHRI | IAISLNKISF | 
    600:
    HQTFYTIQMF | MANVLGLDTC | KHYKERQTNL | RNKVMTLLDE | KFYCLLNDIF | 
    650:
    HVQFPISREI | SRMSTLKKQK | QLEILFMKIL | KLIVKEERII | FIIDEAQFVD | 
    700:
    STSWRFMEKL | IRTLPIFIIM | SLCPFVNIPC | AAARAVIKNR | NTTYIVIGAV | 
    750:
    QPNDISNKIC | LDLNVSCISK | ELDSYLGEGS | CGIPFYCEEL | LKNLEHHEVL | 
    800:
    VFQQTESEEK | TNRTWNNLFK | YSIKLTEKLN | MVTLHSDKES | EEVCHLTSGV | 
    850:
    RLKNLSPPTS | LKEISLIQLD | SMRLSHQMLV | RCAAIIGLTF | TTELLFEILP | 
    900:
    CWNMKMMIKT | LATLVESNIF | YCFRNGKELQ | KALKQNDPSF | EVHYRSLSLK | 
    950:
    PSEGMDHGEE | EQLRELENEV | IECHRIRFCN | PMMQKTAYEL | WLKDQRKAMH | 
    1000:
    LKCARFLEED | AHRCDHCRGR | DFIPYHHFTV | NIRLNALDMD | AIKKMAMSHG | 
    1050:
    FKTEEKLILS | NSEIPETSAF | FPENRSPEEI | REKILNFFDH | VLTKMKTSDE | 
    1100:
    DIIPLESCQC | EEILEIVILP | LAHHFLALGE | NDKALYYFLE | IASAYLIFCD | 
    1150:
    NYMAYMYLNE | GQKLLKTLKK | DKSWSQTFES | ATFYSLKGEV | CFNMGQIVLA | 
    1200:
    KKMLRKALKL | LNRIFPYNLI | SLFLHIHVEK | NRHFHYVNRQ | AQESPPPGKK | 
    1250:
    RLAQLYRQTV | CLSLLWRIYS | YSYLFHCKYY | AHLAVMMQMN | TALETQNCFQ | 
    1300:
    IIKAYLDYSL | YHHLAGYKGV | WFKYEVMAME | HIFNLPLKGE | GIEIVAYVAE | 
    1350:
    TLVFNKLIMG | HLDLAIELGS | RALQMWALLQ | NPNRHYQSLC | RLSRCLLLNS | 
    1400:
    RYPQLIQVLG | RLWELSVTQE | HIFSKAFFYF | VCLDILLYSG | FVYRTFEECL | 
    1450:
    EFIHQYENNR | ILKFHSGLLL | GLYSSVAIWY | ARLQEWDNFY | KFSNRAKNLL | 
    1500:
    PRRTMTLTYY | DGISRYMEGQ | VLHLQKQIKE | QSENAQASGE | ELLKNLENLV | 
    1550:
    AQNTTGPVFC | PRLYHLMAYV | CILMGDGQKC | GLFLNTALRL | SETQGNILEK | 
    1600:
    CWLNMNKESW | YSTSELKEDQ | WLQTILSLPS | WEKIVAGRVN | IQDLQKNKFL | 
    1610:
    MRANTVDNHF | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    SMR:
    Pfam:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Adenylate cyclase type 10
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    E1348r
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    ELISA Kit for Human Adenylate cyclase type 10
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    E1348h
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    96T
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    ELISA Kit for Human Adenylate cyclase type 10
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    E1348m
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    Packing:
    96T
    ELISA Kit for Human Adenylate cyclase type 10
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    CLIA Kit for Human Adenylate cyclase type 10
    Cat.:
    U1348m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Adenylate cyclase type 10
    Cat.:
    U1348h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Adenylate cyclase type 10
    Cat.:
    U1348r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Adenylate cyclase type 10
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Adenylate cyclase type 10
    Cat.:
    P1348Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Adenylate cyclase type 10
    Polyclonal Antibody for Human Adenylate cyclase type 10
    Cat.:
    P1348Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Adenylate cyclase type 10
    Cat.:
    P1348Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Adenylate cyclase type 10
    Monoclonal Antibody for Human Adenylate cyclase type 10
    Monoclonal Antibody for Human Adenylate cyclase type 10
    Monoclonal Antibody for Human Adenylate cyclase type 10
    Protein for Human Adenylate cyclase type 10
    Protein for Human Adenylate cyclase type 10
    Protein for Human Adenylate cyclase type 10
    Protein for Human Adenylate cyclase type 10

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    References
    1. 1.
      "Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase."
      Jaiswal B.S. , Conti M.
      J. Biol. Chem.276:31698-31708(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT VAL-697
    2. 2.
      "Identification and characterization of a gene with base substitutions associated with the absorptive hypercalciuria phenotype and low spinal bone density."
      Reed B.Y. , Gitomer W.L. , Heller H.J. , Hsu M.C. , Lemke M. , Padalino P. , Pak C.Y.C.
      J. Clin. Endocrinol. Metab.87:1476-1485(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;INVOLVEMENT IN HCA2;VARIANT VAL-697
      tissue: Intestine.
    3. 3.
      "Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate."
      Litvin T.N. , Kamenetsky M. , Zarifyan A. , Buck J. , Levin L.R.
      J. Biol. Chem.278:15922-15926(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);BIOPHYSICOCHEMICAL PROPERTIES;VARIANT VAL-697
    4. 4.
      "Cloning of a human testicular soluble adenylyl cyclase."
      Khole V.V. , Westbrook V.A. , Mandal A. , Herr J.C. , Visconti P.E.
      Submitted (2000-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    5. 5.
      Rhodes S.
      Submitted (1999-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Testis.
    7. 7.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    10. 10.
      "Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains."
      Zippin J.H. , Chen Y. , Nahirney P. , Kamenetsky M. , Wuttke M.S. , Fischman D.A. , Levin L.R. , Buck J.
      FASEB J.17:82-84(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    11. 11.
      "Cloning and characterization of the human soluble adenylyl cyclase."
      Geng W. , Wang Z. , Zhang J. , Reed B.Y. , Pak C.Y.C. , Moe O.W.
      Am. J. Physiol.288:C1305-C1316(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;ENZYME REGULATION;SUBCELLULAR LOCATION;FUNCTION
    12. 12.
      "Soluble adenylyl cyclase is localized to cilia and contributes to ciliary beat frequency regulation via production of cAMP."
      Schmid A. , Sutto Z. , Nlend M.-C. , Horvath G. , Schmid N. , Buck J. , Levin L.R. , Conner G.E. , Fregien N. , Salathe M.
      J. Gen. Physiol.130:99-109(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
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