Gene name:
Adcy10 (Sac;Sacy) ;
Protein name:
Adenylate cyclase type 10 ;
Alternative:
Testicular soluble adenylyl cyclase ;Germ cell soluble adenylyl cyclase (sAC) ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.
Subcellular Location:
Cell membrane
Peripheral membrane protein
Cytoplasmic side
Cytoplasm
cytoskeleton
Cytoplasm
perinuclear region
Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin.
Protein Attributes:
50:
MSARRQELQD | RAIVKIAAHL | PDLIVYGDFS | PERPSVKCFD | GVLMFVDISG |
100:
FTAMTEKFST | AMYMDRGAEQ | LVEILNYYIS | AIVEKVLIFG | GDILKFAGDA |
150:
LLALWKVERK | QLKNIITVVI | KCSLEIHGLF | EAKEAEEGLD | IRVKIGLAAG |
200:
HITMLVFGDE | TRNYFLVIGQ | AVDDVRLAQN | MAQMNDVILS | PNCWQLCDRS |
250:
MIEIERIPDQ | RAVKVSFLKP | PPTFNFDEFF | TKCMGFMDYY | PSGDHKNFLR |
300:
LACMLESDPE | LELSLQKYVM | EIILKQIDDK | QLRGYLSELR | PVTIVFVNLM |
350:
FKEQDKVEVI | GSAIQAACVH | ITSVLKVFRG | QINKVFMFDK | GCSFLCVFGF |
400:
PGEKAPDEIT | HALESAVDIF | DFCSQVHKIR | TVSIGVASGI | VFCGIVGHTV |
450:
RHEYTVIGQK | VNIAARMMMY | YPGIVSCDSV | TYDGSNLPAY | FFKELPKKVM |
500:
KGVADPGPVY | QCLGLNEKVM | FGMAYLICNR | YEGYPLLGRV | REIDYFMSTM |
550:
KDFLMTNCSR | VLMYEGLPGY | GKSQVLMEIE | YLASQHENHR | AVAIALTKIS |
600:
FHQNFYTIQI | LMANVLGLDT | CKHYKERQTN | LQNRVKTLLD | EKFHCLLNDI |
650:
FHVQFPVSRE | MSRMSKIRKQ | KQLEALFMKI | LAQTVREERI | IFIIDEAQFV |
700:
DGTSWAFIEK | LIRSMPIFIV | MSLAPFSEVP | CAAANAIMKN | RNTTYITLGT |
750:
MQPQEIRDKV | CVDLSVSSIP | RELDSYLVEG | SCGIPYYCEE | LLKNLDHHRV |
800:
LLFQQAETEQ | KTNVTWNNMF | KHSVRPTDDM | QLFTSISEGQ | KEVCYLVSGV |
850:
RLNNLSPPAS | LKEISLVQLD | SMSLSHQMLV | RCAAIIGLTF | TTELLFEILP |
900:
CWNMKMMIKA | LATLVESNVF | NCFRSSKDLQ | LALKQNVPTF | EVHYRSLALK |
950:
LKEGLTYGEE | EELREMEGEV | VECRILRFCR | PIMQKTAYEL | WLKDQKKVLH |
1000:
LKCARFLEES | AHRCNHCRNV | DFIPYHHFIV | DIRLNTLDMD | TVKRMVTSQG |
1050:
FKIDEEEAIF | SKSELPRKYK | FPENLSITEI | REKILHFFDN | VILKMKSSPN |
1100:
DIIPLESCQC | KELLQIVILP | LAQHFVALEE | NNKALYYFLE | LASAYLILGD |
1150:
NYNAYMYLGE | GERLLKSLTN | EDSWSQTFEY | ATFYSLKAEV | CFNMGQMVLA |
1200:
KKMLRKALKL | LNRMFPCNLL | TLTFQMHVEK | NRLSHFMNQH | TQEGSVPGKK |
1250:
LAQLYLQASC | FSLLWRIYSL | NFFFHYKYYG | HLAAMMEMNT | SLETQNDFQI |
1300:
IKAYLDFSLY | HHLAGYQGVW | FKYEILVMEQ | LLNLPLKGEA | IEIMAYTADT |
1350:
LGHIKFLMGH | LDLAIELGSR | AHRMWSLLRN | PNKYQMVLCR | LSKPLFLKSR |
1400:
YKHLVQVLGW | LWDLSVTEED | IFSKAFFYFV | CLDIMLYSGF | IYRTFEECLE |
1450:
FIHHNEDNRI | LKFQSGLLLG | LYSCIAVWYA | RLQEWDNFNK | FSDRAKHLVT |
1500:
RRTPTVLYYE | GISRYMEGQV | LHLQKQIEEQ | AENAQDSGVE | ILKALETLVA |
1550:
QNTTGPVFYP | RLYHLMAYVC | ILMGDGHSCD | FFLNTALELS | ETHGNLLEKC |
1600:
WLSMSKEWWY | SASELTGDQW | LQTVLSLPSW | DKIVSGKGGQ | RKRSWSWFCP |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
Rabbit
ELISA Kit for Mouse Adenylate cyclase type 10
ELISA Kit for Mouse Adenylate cyclase type 10
ELISA Kit for Mouse Adenylate cyclase type 10
ELISA Kit for Mouse Adenylate cyclase type 10
CLIA Kit for Mouse Adenylate cyclase type 10
CLIA Kit for Mouse Adenylate cyclase type 10
CLIA Kit for Mouse Adenylate cyclase type 10
CLIA Kit for Mouse Adenylate cyclase type 10
Polyclonal Antibody for Mouse Adenylate cyclase type 10
Polyclonal Antibody for Mouse Adenylate cyclase type 10
Polyclonal Antibody for Mouse Adenylate cyclase type 10
Polyclonal Antibody for Mouse Adenylate cyclase type 10
Monoclonal Antibody for Mouse Adenylate cyclase type 10
Monoclonal Antibody for Mouse Adenylate cyclase type 10
Monoclonal Antibody for Mouse Adenylate cyclase type 10
Monoclonal Antibody for Mouse Adenylate cyclase type 10
Protein for Mouse Adenylate cyclase type 10
Protein for Mouse Adenylate cyclase type 10
Protein for Mouse Adenylate cyclase type 10
Protein for Mouse Adenylate cyclase type 10
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"The transcriptional landscape of the mammalian genome."
Carninci P.
,
Kasukawa T.
,
Katayama S.
,
Gough J.
,
Frith M.C.
,
Maeda N.
,
Oyama R.
,
Ravasi T.
,
Lenhard B.
,
Wells C.
,
Kodzius R.
,
Shimokawa K.
,
Bajic V.B.
,
Brenner S.E.
,
Batalov S.
,
Forrest A.R.
,
Zavolan M.
,
Davis M.J.
,
Wilming L.G.
,
Aidinis V.
,
Allen J.E.
,
Ambesi-Impiombato A.
,
Apweiler R.
,
Aturaliya R.N.
,
Bailey T.L.
,
Bansal M.
,
Baxter L.
,
Beisel K.W.
,
Bersano T.
,
Bono H.
,
Chalk A.M.
,
Chiu K.P.
,
Choudhary V.
,
Christoffels A.
,
Clutterbuck D.R.
,
Crowe M.L.
,
Dalla E.
,
Dalrymple B.P.
,
de Bono B.
,
Della Gatta G.
,
di Bernardo D.
,
Down T.
,
Engstrom P.
,
Fagiolini M.
,
Faulkner G.
,
Fletcher C.F.
,
Fukushima T.
,
Furuno M.
,
Futaki S.
,
Gariboldi M.
,
Georgii-Hemming P.
,
Gingeras T.R.
,
Gojobori T.
,
Green R.E.
,
Gustincich S.
,
Harbers M.
,
Hayashi Y.
,
Hensch T.K.
,
Hirokawa N.
,
Hill D.
,
Huminiecki L.
,
Iacono M.
,
Ikeo K.
,
Iwama A.
,
Ishikawa T.
,
Jakt M.
,
Kanapin A.
,
Katoh M.
,
Kawasawa Y.
,
Kelso J.
,
Kitamura H.
,
Kitano H.
,
Kollias G.
,
Krishnan S.P.
,
Kruger A.
,
Kummerfeld S.K.
,
Kurochkin I.V.
,
Lareau L.F.
,
Lazarevic D.
,
Lipovich L.
,
Liu J.
,
Liuni S.
,
McWilliam S.
,
Madan Babu M.
,
Madera M.
,
Marchionni L.
,
Matsuda H.
,
Matsuzawa S.
,
Miki H.
,
Mignone F.
,
Miyake S.
,
Morris K.
,
Mottagui-Tabar S.
,
Mulder N.
,
Nakano N.
,
Nakauchi H.
,
Ng P.
,
Nilsson R.
,
Nishiguchi S.
,
Nishikawa S.
,
Nori F.
,
Ohara O.
,
Okazaki Y.
,
Orlando V.
,
Pang K.C.
,
Pavan W.J.
,
Pavesi G.
,
Pesole G.
,
Petrovsky N.
,
Piazza S.
,
Reed J.
,
Reid J.F.
,
Ring B.Z.
,
Ringwald M.
,
Rost B.
,
Ruan Y.
,
Salzberg S.L.
,
Sandelin A.
,
Schneider C.
,
Schoenbach C.
,
Sekiguchi K.
,
Semple C.A.
,
Seno S.
,
Sessa L.
,
Sheng Y.
,
Shibata Y.
,
Shimada H.
,
Shimada K.
,
Silva D.
,
Sinclair B.
,
Sperling S.
,
Stupka E.
,
Sugiura K.
,
Sultana R.
,
Takenaka Y.
,
Taki K.
,
Tammoja K.
,
Tan S.L.
,
Tang S.
,
Taylor M.S.
,
Tegner J.
,
Teichmann S.A.
,
Ueda H.R.
,
van Nimwegen E.
,
Verardo R.
,
Wei C.L.
,
Yagi K.
,
Yamanishi H.
,
Zabarovsky E.
,
Zhu S.
,
Zimmer A.
,
Hide W.
,
Bult C.
,
Grimmond S.M.
,
Teasdale R.D.
,
Liu E.T.
,
Brusic V.
,
Quackenbush J.
,
Wahlestedt C.
,
Mattick J.S.
,
Hume D.A.
,
Kai C.
,
Sasaki D.
,
Tomaru Y.
,
Fukuda S.
,
Kanamori-Katayama M.
,
Suzuki M.
,
Aoki J.
,
Arakawa T.
,
Iida J.
,
Imamura K.
,
Itoh M.
,
Kato T.
,
Kawaji H.
,
Kawagashira N.
,
Kawashima T.
,
Kojima M.
,
Kondo S.
,
Konno H.
,
Nakano K.
,
Ninomiya N.
,
Nishio T.
,
Okada M.
,
Plessy C.
,
Shibata K.
,
Shiraki T.
,
Suzuki S.
,
Tagami M.
,
Waki K.
,
Watahiki A.
,
Okamura-Oho Y.
,
Suzuki H.
,
Kawai J.
,
Hayashizaki Y.
more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
strain :
C57BL/6J .
tissue :
Testis .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
5.
"Mice deficient for soluble adenylyl cyclase are infertile because of a severe sperm-motility defect."
Esposito G.
,
Jaiswal B.S.
,
Xie F.
,
Krajnc-Franken M.A.M.
,
Robben T.J.A.A.
,
Strik A.M.
,
Kuil C.
,
Philipsen R.L.A.
,
van Duin M.
,
Conti M.
,
Gossen J.A.
Proc. Natl. Acad. Sci. U.S.A.101:2993-2998(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
6.
"The 'soluble' adenylyl cyclase in sperm mediates multiple signaling events required for fertilization."
Hess K.C.
,
Jones B.H.
,
Marquez B.
,
Chen Y.
,
Ord T.S.
,
Kamenetsky M.
,
Miyamoto C.
,
Zippin J.H.
,
Kopf G.S.
,
Suarez S.S.
,
Levin L.R.
,
Williams C.J.
,
Buck J.
,
Moss S.B.
Dev. Cell9:249-259(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;TISSUE SPECIFICITY