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Index > Protein center > Adcy10(Gene name) > Rat
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  • Adcy10 (Gene name),
  • Adenylate cyclase type 10 (Protein name ),  ADCYA_RAT from NCBI database.
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  • Gene name:
    Adcy10(Sac);
    Protein name:
    Adenylate cyclase type 10;
    Alternative:
    Testicular soluble adenylyl cyclase;Germ cell soluble adenylyl cyclase(sAC);
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Soluble adenylyl cyclase that has a critical role in mammalian spermatogenesis. Produces the cAMP which mediates in part the cAMP-responsive nuclear factors indispensable for maturation of sperm in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization. May be the bicarbonate sensor.
    Subcellular Location:
    Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasm cytoskeleton Mitochondrion Cytoplasm perinuclear region Cytoplasm cytoskeleton centrosome centriole Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane-associated protein, protein concentrated in the perinuclear region and protein colocalized with actin, tubulin or centriole.
    Protein Attributes:
    Sequence length:
    1608
    Sequence:
    50:
    MSARRQELQD | RAIVKIAAHL | PDLIVYGDFS | PERPSVKCFD | GVLMFVDISG | 
    100:
    FTAMTEKFST | AMYMDRGAEQ | LVEILNYYIS | AIVEKVLIFG | GDILKFAGDA | 
    150:
    LLALWKVERK | QLKNIITVVI | KCSLEIHGLF | EAKEVEEGLD | IRVKIGLAAG | 
    200:
    HITMLVFGDE | TRNYFLVIGQ | AVDDVRLAQN | MAQMNDVILS | PNCWQLCDRS | 
    250:
    MIEIERIPDQ | RAVKVSFLKP | PPTFNFDEFF | AKCMAFMDYY | PSGDHKNFLR | 
    300:
    LACMLESDPE | LELSLQKYVM | EIILKQIDDK | QLRGYLSELR | PVTIVFVNLM | 
    350:
    FKEQDKAEVI | GSAIQAACVH | ITSVLKVFRG | QINKVFMFDK | GCSFLCVFGF | 
    400:
    PGEKAPDEIT | HALESAVDIF | DFCSQVHKIR | TVSIGVASGI | VFCGIVGHTV | 
    450:
    RHEYTVIGQK | VNIAARMMMY | YPGIVTCDSV | TYDGSNLPAY | FFKELPKKVM | 
    500:
    KGVADPGPVY | QCLGLNEKVM | FGMAYLICNR | YEGYPLLGRV | REIDYFMSTM | 
    550:
    KDFLMTNCSR | VLMYEGLPGY | GKSQVLMEIE | YLASQHENHR | AVAIALTKIS | 
    600:
    FHQNFYTIQI | LMANVLGLDT | CKHYKERQTN | LQNRVKTLLD | DKYHCLLNDI | 
    650:
    FHVQFPVSRE | MSRMSKIRKQ | KQLEALFMKI | LEQTVREERI | IFIIDEAQFV | 
    700:
    DVASWAFIEK | LIRSMPIFIV | MSLCPFPETP | CAAANAIMKN | RNTTYITLGT | 
    750:
    MQPQEIRDKV | CVDLSVSSIP | RELDSYLVEG | SCGIPYYCEE | LLKNLDHHRI | 
    800:
    LIFQQAEAEE | KTNVTWNNLF | KYSVKPTEDM | YLYTSIAAGQ | KEACYLTSGV | 
    850:
    RLKNLSPPAS | LKEISLVQLD | SMSLSHQMLV | RCAAIIGLTF | TTELLFEILP | 
    900:
    CWNMKMMIKA | LATLVESNVF | DCFRSSKDLQ | LALKQNVTTF | EVHYRSLSLK | 
    950:
    SKEGLAYSEE | EQLREMEGEV | IECRILRFCR | PIMQKTAYEL | WLKDQKKVLH | 
    1000:
    LKCARFLEES | AHRCNHCRNR | DFIPYHHFIA | DIRLNTLDMD | TVKKMVKSHG | 
    1050:
    FKTEDEVIFS | KSEIPRKFKF | PENISITETR | EKILHFFDNV | IIKMRTSQDD | 
    1100:
    VIPLESCHCE | ELLQIVILPL | AQHFVALEEN | NKALYYFLEL | ASAYLILGDN | 
    1150:
    YNAYMYLGEG | ERLLKSLTNE | DSWSQTFEYA | TFYSLKGEIC | FNMGQMVLAK | 
    1200:
    KMLRKALKLL | NRMFPCNLLS | LTFQMHIEKN | RLSHFMNQHT | QEGSLPGKKL | 
    1250:
    AQLFLQSSCF | SLLWKIYSLN | FFFHYKYYGR | LAAIMQMNTS | LETQNNFQII | 
    1300:
    KAFLDFSLYR | HLAGYEGVWF | KYEILVMEQL | LNLPLKGEAF | EIMAYAADAL | 
    1350:
    GHIKFLTGHL | DLAIELGSRA | HKMWSLLRNP | NKYHMVLCRL | SKPLFLKSRY | 
    1400:
    KHLVQVLGWL | WDLSVTEEHI | FSKAFFYFVC | LDIMLYSGFI | YRTFEECLEF | 
    1450:
    IHHNEDNRIL | KFQSGLLLGL | YSCIAVWYAR | LQEWDNFYKF | SNRAKTLVTR | 
    1500:
    RTPTVLYYEG | ISRYMEGQVL | HLQKQIEEQA | ENAQDSGVEL | LKALETLVAQ | 
    1550:
    NTTGPVFYPR | LYHLMAYVCI | LMGDGHSCDF | FLNTALELSE | TQGNLLEKCW | 
    1600:
    LSMSKEWWYS | APELTGDQWL | QTVLSLPSWD | KIVSGNVTLQ | DVQKNKFLMR | 
    1608:
    VNILDNPF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat Adenylate cyclase type 10
    Cat.:
    E1348r
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Rat Adenylate cyclase type 10
    Cat.:
    E1348h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    ELISA Kit for Rat Adenylate cyclase type 10
    Cat.:
    E1348m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Rat Adenylate cyclase type 10
    MSDS:
    Please sign in first.
    CLIA Kit for Rat Adenylate cyclase type 10
    Cat.:
    U1348m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat Adenylate cyclase type 10
    Cat.:
    U1348h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Adenylate cyclase type 10
    Cat.:
    U1348r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat Adenylate cyclase type 10
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Rat Adenylate cyclase type 10
    Cat.:
    P1348Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Adenylate cyclase type 10
    Polyclonal Antibody for Rat Adenylate cyclase type 10
    Cat.:
    P1348Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat Adenylate cyclase type 10
    Cat.:
    P1348Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat Adenylate cyclase type 10
    Monoclonal Antibody for Rat Adenylate cyclase type 10
    Monoclonal Antibody for Rat Adenylate cyclase type 10
    Monoclonal Antibody for Rat Adenylate cyclase type 10
    Protein for Rat Adenylate cyclase type 10
    Protein for Rat Adenylate cyclase type 10
    Protein for Rat Adenylate cyclase type 10
    Protein for Rat Adenylate cyclase type 10

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    References
    1. 1.
      "Cytosolic adenylyl cyclase defines a unique signaling molecule in mammals."
      Buck J. , Sinclair M.L. , Schapal L. , Cann M.J. , Levin L.R.
      Proc. Natl. Acad. Sci. U.S.A.96:79-84(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 60-67; 254-262 AND 402-409;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      strain: Sprague-Dawley.
      tissue: Testis.
    2. 2.
      "Identification and functional analysis of splice variants of the germ cell soluble adenylyl cyclase."
      Jaiswal B.S. , Conti M.
      J. Biol. Chem.276:31698-31708(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING
    3. 3.
      "Compartmentalization of bicarbonate-sensitive adenylyl cyclase in distinct signaling microdomains."
      Zippin J.H. , Chen Y. , Nahirney P. , Kamenetsky M. , Wuttke M.S. , Fischman D.A. , Levin L.R. , Buck J.
      FASEB J.17:82-84(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    4. 4.
      "Kinetic properties of 'soluble' adenylyl cyclase. Synergism between calcium and bicarbonate."
      Litvin T.N. , Kamenetsky M. , Zarifyan A. , Buck J. , Levin L.R.
      J. Biol. Chem.278:15922-15926(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: BIOPHYSICOCHEMICAL PROPERTIES
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