Agap2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comAgap2 ELISA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Agap2(Gene name) > Rat

Agap2 (Gene name),

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (Protein name ), AGAP2_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Agap2(Centg1);

Protein name:

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2(AGAP-2);

Alternative:

Phosphatidylinositol-3-kinase enhancer(PIKE);Centaurin-gamma-1(Cnt-g1);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2.

Function:

GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. Aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

1186

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1050:

1100:

1150:

1186:

TTPSAATTPS | ITATPSPRRR | SSAASLGRVD | TTIALV

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

UniGene:

Rn.91094

SMR:

Q8CGU4

String:

Q8CGU4

STRING:

10116.ENSRNOP00000029533

Pfam:

PF12796

KEGG:

rno:65218

Uniprot:

Q8CGU4

FOR

ELISA Kit for Rat AGAP-2

CLIA Kit for Rat AGAP-2

Polyclonal Antibody for Rat AGAP-2

Monoclonal Antibody for Rat AGAP-2

Protein for Rat AGAP-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis."
Rong R. , Ahn J.-Y. , Huang H. , Nagata E. , Kalman D. , Kapp J.A. , Tu J. , Worley P.F. , Snyder S.H. , Ye K.
Nat. Neurosci.6:1153-1161(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH HOMER1 AND HOMER2;MUTAGENESIS OF PRO-187
strain: Brown Norway.
tissue: Brain.
2.

"PIKE: a nuclear GTPase that enhances PI3kinase activity and is regulated by protein 4.1N."
Ye K. , Hurt K.J. , Wu F.Y. , Fang M. , Luo H.R. , Hong J.J. , Blackshaw S. , Ferris C.D. , Snyder S.H.
Cell103:919-930(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-754;GTP-BINDING;TISSUE SPECIFICITY;INTERACTION WITH EPB41L1;SUBCELLULAR LOCATION;FUNCTION;MUTAGENESIS OF SER-414
3.

"Phospholipase C gamma 1 is a physiological guanine nucleotide exchange factor for the nuclear GTPase PIKE."
Ye K. , Aghdasi B. , Luo H.R. , Moriarity J.L. , Wu F.Y. , Hong J.J. , Hurt K.J. , Bae S.S. , Suh P.-G. , Snyder S.H.
Nature415:541-544(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PLCG1
4.

"PIKE/nuclear PI 3-kinase signaling mediates the antiapoptotic actions of NGF in the nucleus."
Ahn J.-Y. , Rong R. , Liu X. , Ye K.
EMBO J.23:3995-4006(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
5.

"Neurofibromatosis 2 (NF2) tumor suppressor merlin inhibits phosphatidylinositol 3-kinase through binding to PIKE-L."
Rong R. , Tang X. , Gutmann D.H. , Ye K.
Proc. Natl. Acad. Sci. U.S.A.101:18200-18205(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INTERACTION WITH NF2;MUTAGENESIS OF PRO-187
6.

"Phosphoinositol lipids bind to phosphatidylinositol 3 (PI3)-kinase enhancer GTPase and mediate its stimulatory effect on PI3-kinase and Akt signalings."
Hu Y. , Liu Z. , Ye K.
Proc. Natl. Acad. Sci. U.S.A.102:16853-16858(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-679 AND LYS-687

Product Feedback Wall

* Email:
*Comments: