AICDA ELISA Kit for Human(Homo sapiens) | EIAab.comAICDA ELISA Kit for Human(Homo sapiens)

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Index > Protein center > AICDA(Gene name) > Human

AICDA (Gene name),

Activation-induced cytidine deaminase (Protein name ), AICDA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

AICDA(AID);

Protein name:

Activation-induced cytidine deaminase;

Alternative:

Cytidine aminohydrolase;Cytidine aminohydrolase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class-switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating to DNA demethylation.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

198

Sequence:

50:

100:

150:

198:

FVENHERTFK | AWEGLHENSV | RLSRQLRRIL | LPLYEVDDLR | DAFRTLGL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9GZX7

String:

Q9GZX7

STRING:

9606.ENSP00000229335

Pfam:

PF08210

Pfam:

PF05240

KEGG:

hsa:57379

MIM:

605257

UniGene:

Hs.149342

Uniprot:

Q9GZX7

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ELISA Kit for Human Activation-induced cytidine deaminase

Cat.:

E14184d

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96T

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ELISA Kit for Human Activation-induced cytidine deaminase

Cat.:

E14184h

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Looking for manual.

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96T

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ELISA Kit for Human Activation-induced cytidine deaminase

Cat.:

E14184m

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Packing:

96T

ELISA Kit for Human Activation-induced cytidine deaminase

Cat.:

E14184b

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Packing:

96T

CLIA Kit for Human Activation-induced cytidine deaminase

Cat.:

U14184d

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MSDS:

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Packing:

96T

CLIA Kit for Human Activation-induced cytidine deaminase

Cat.:

U14184h

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MSDS:

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Packing:

96T

CLIA Kit for Human Activation-induced cytidine deaminase

Cat.:

U14184m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Human Activation-induced cytidine deaminase

Cat.:

U14184b

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Packing:

96T

Polyclonal Antibody for Human Activation-induced cytidine deaminase

Cat.:

P14184Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Activation-induced cytidine deaminase

Cat.:

P14184Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Activation-induced cytidine deaminase

Monoclonal Antibody for Human Activation-induced cytidine deaminase

Protein for Human Activation-induced cytidine deaminase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Isolation, tissue distribution, and chromosomal localization of the human activation-induced cytidine deaminase (hAID) gene."
Muto T. , Muramatsu M. , Taniwaki M. , Kinoshita K. , Honjo T.
Genomics68:85-88(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
2.

"Activation-induced cytidine deaminase (AID) deficiency causes the autosomal recessive form of the Hyper-IgM syndrome (HIGM2)."
Revy P. , Muto T. , Levy Y. , Geissmann F. , Plebani A. , Sanal O. , Catalan N. , Forveille M. , Dufourcq-Lagelouse R. , Gennery A. , Tezcan I. , Ersoy F. , Kayserili H. , Ugazio A.G. , Brousse N. , Muramatsu M. , Notarangelo L.D. , Kinoshita K. , more...
Cell102:565-575(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);VARIANTS HIGM2 TRP-24; ARG-80; PRO-106; VAL-139 AND SER-151
3.

"Somatic hypermutation of the AID transgene in B and non-B cells."
Martin A. , Scharff M.D.
Proc. Natl. Acad. Sci. U.S.A.99:12304-12308(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"Intracellular localization of AID isoforms."
Roa S. , Gonzalez-Sarmiento R.
Submitted (2004-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
5.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
6.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: B-cell.
8.

"Activation-induced cytidine deaminase shuttles between nucleus and cytoplasm like apolipoprotein B mRNA editing catalytic polypeptide 1."
Ito S. , Nagaoka H. , Shinkura R. , Begum N. , Muramatsu M. , Nakata M. , Honjo T.
Proc. Natl. Acad. Sci. U.S.A.101:1975-1980(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
9.

"PKA-mediated phosphorylation regulates the function of activation-induced deaminase (AID) in B cells."
Pasqualucci L. , Kitaura Y. , Gu H. , Dalla-Favera R.
Proc. Natl. Acad. Sci. U.S.A.103:395-400(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-27 AND SER-38;INTERACTION WITH PRKACA AND PRKAR1A;MUTAGENESIS OF THR-27 AND SER-38
10.

"Interaction between antibody-diversification enzyme AID and spliceosome-associated factor CTNNBL1."
Conticello S.G. , Ganesh K. , Xue K. , Lu M. , Rada C. , Neuberger M.S.
Mol. Cell31:474-484(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNBL1;FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-38;IDENTIFICATION BY MASS SPECTROMETRY;MUTAGENESIS OF 39-ALA--PHE-42 AND SER-38
11.

"Hydroxylation of 5-methylcytosine by TET1 promotes active DNA demethylation in the adult brain."
Guo J.U. , Su Y. , Zhong C. , Ming G.L. , Song H.
Cell145:423-434(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN DNA DEMETHYLATION
12.

"CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31."
Ganesh K. , Adam S. , Taylor B. , Simpson P. , Rada C. , Neuberger M.
J. Biol. Chem.286:17091-17102(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CTNNBL1;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-10; VAL-18; ARG-19; TRP-20; ARG-50; ARG-112 AND PHE-193;CHARACTERIZATION OF VARIANT TRP-24
13.

"Phosphorylation directly regulates the intrinsic DNA cytidine deaminase activity of activation-induced deaminase and APOBEC3G protein."
Demorest Z.L. , Li M. , Harris R.S.
J. Biol. Chem.286:26568-26575(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;MUTAGENESIS OF THR-27
14.

"Histone chaperone Spt6 is required for class switch recombination but not somatic hypermutation."
Okazaki I.M. , Okawa K. , Kobayashi M. , Yoshikawa K. , Kawamoto S. , Nagaoka H. , Shinkura R. , Kitawaki Y. , Taniguchi H. , Natsume T. , Iemura S. , Honjo T.
Proc. Natl. Acad. Sci. U.S.A.108:7920-7925(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SUPT6H
15.

"BCL6 positively regulates AID and germinal center gene expression via repression of miR-155."
Basso K. , Schneider C. , Shen Q. , Holmes A.B. , Setty M. , Leslie C. , Dalla-Favera R.
J. Exp. Med.209:2455-2465(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
16.

"Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase."
Delker R.K. , Zhou Y. , Strikoudis A. , Stebbins C.E. , Papavasiliou F.N.
Proc. Natl. Acad. Sci. U.S.A.110:1029-1034(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF126;UBIQUITINATION BY RNF126
17.

"Association between a new polymorphism in the activation-induced cytidine deaminase gene and atopic asthma and the regulation of total serum IgE levels."
Noguchi E. , Shibasaki M. , Inudou M. , Kamioka M. , Yokouchi Y. , Yamakawa-Kobayashi K. , Hamaguchi H. , Matsui A. , Arinami T.
J. Allergy Clin. Immunol.108:382-386(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT CYS-25

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