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Index > Protein center > AKR1C1(Gene name) > Human
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  • AKR1C1 (Gene name),
  • Aldo-keto reductase family 1 member C1 (Protein name ),  AK1C1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AKR1C1(DDH;DDH1);
    Protein name:
    Aldo-keto reductase family 1 member C1;
    Alternative:
    1.3.1.20;Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase);1.1.1.112;Indanol dehydrogenase);High-affinity hepatic bile acid-binding protein(HBAB);Dihydrodiol dehydrogenase 1/2(DD1/DD2);1.1.1.149;20-alpha-hydroxysteroid dehydrogenase(20-alpha-HSD);Chlordecone reductase homolog HAKRC;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    323
    Sequence:
    50:
    MDSKYQCVKL | NDGHFMPVLG | FGTYAPAEVP | KSKALEATKL | AIEAGFRHID | 
    100:
    SAHLYNNEEQ | VGLAIRSKIA | DGSVKREDIF | YTSKLWCNSH | RPELVRPALE | 
    150:
    RSLKNLQLDY | VDLYLIHFPV | SVKPGEEVIP | KDENGKILFD | TVDLCATWEA | 
    200:
    VEKCKDAGLA | KSIGVSNFNR | RQLEMILNKP | GLKYKPVCNQ | VECHPYFNQR | 
    250:
    KLLDFCKSKD | IVLVAYSALG | SHREEPWVDP | NSPVLLEDPV | LCALAKKHKR | 
    300:
    TPALIALRYQ | LQRGVVVLAK | SYNEQRIRQN | VQVFEFQLTS | EEMKAIDGLN | 
    323:
    RNVRYLTLDI | FAGPPNYPFS | DEY
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    SMR:
    KEGG:
    String:
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Aldo-keto reductase family 1 member C1
    Cat.:
    E14181h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Aldo-keto reductase family 1 member C1
    Cat.:
    U14181h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Aldo-keto reductase family 1 member C1
    Monoclonal Antibody for Human Aldo-keto reductase family 1 member C1
    Protein for Human Aldo-keto reductase family 1 member C1

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "cDNA cloning and expression of the human hepatic bile acid-binding protein. A member of the monomeric reductase gene family."
      Stolz A. , Hammond L. , Lou H. , Takikawa H. , Ronk M. , Shively J.E.
      J. Biol. Chem.268:10448-10457(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    2. 2.
      "Genomic organization and chromosomal localization of a novel human hepatic dihydrodiol dehydrogenase with high affinity bile acid binding."
      Lou H. , Hammond L. , Sharma V. , Sparkes R.S. , Lusis A.J. , Stolz A.
      J. Biol. Chem.269:8416-8422(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Blood.
    3. 3.
      "Regulation of human dihydrodiol dehydrogenase by Michael acceptor xenobiotics."
      Ciaccio P.J. , Jaiswal A.K. , Tew K.D.
      J. Biol. Chem.269:15558-15562(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Colon.
    4. 4.
      "Distribution of 3 alpha-hydroxysteroid dehydrogenase in rat brain and molecular cloning of multiple cDNAs encoding structurally related proteins in humans."
      Khanna M. , Qin K.-N. , Cheng K.-C.
      J. Steroid Biochem. Mol. Biol.53:41-46(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    5. 5.
      "Close kinship of human 20alpha-hydroxysteroid dehydrogenase gene with three aldo-keto reductase genes."
      Nishizawa M. , Nakajima T. , Yasuda K. , Kanzaki H. , Sasaguri Y. , Watanabe K. , Ito S.
      Genes Cells5:111-125(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Liver.
    6. 6.
      "Characterization of a human 20alpha-hydroxysteroid dehydrogenase."
      Zhang Y. , Dufort I. , Rheault P. , Luu-The V.
      J. Mol. Endocrinol.25:221-228(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;TISSUE SPECIFICITY
      tissue: Skin fibroblast.
    7. 7.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
      tissue: Testis.
    10. 10.
      "Molecular cloning of multiple cDNAs encoding human enzymes structurally related to 3 alpha-hydroxysteroid dehydrogenase."
      Qin K.-N. , New M.I. , Cheng K.-C.
      J. Steroid Biochem. Mol. Biol.46:673-679(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 4-323
      tissue: Liver.
    11. 11.
      "Relationship of human liver dihydrodiol dehydrogenases to hepatic bile-acid-binding protein and an oxidoreductase of human colon cells."
      Hara A. , Matsuura K. , Tamada Y. , Sato K. , Miyabe Y. , Deyashiki Y. , Ishida N.
      Biochem. J.313:373-376(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 10-31; 40-61; 69-126; 137-153; 162-206; 209-230; 250-267; 271-289 AND 295-323;FUNCTION;CATALYTIC ACTIVITY;ENZYME REGULATION;BIOPHYSICOCHEMICAL PROPERTIES
    12. 12.
      "Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder."
      Deyashiki Y. , Ogasawara A. , Nakayama T. , Nakanishi M. , Miyabe Y. , Sato K. , Hara A.
      Biochem. J.299:545-552(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 18-323;PROTEIN SEQUENCE OF 18-31; 105-131; 176-193 AND 271-294
      tissue: Liver.
    13. 13.
      "Human 20alpha-hydroxysteroid dehydrogenase: crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids."
      Couture J.-F. , Legrand P. , Cantin L. , Luu-The V. , Labrie F. , Breton R.
      J. Mol. Biol.331:593-604(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEX WITH NADP AND 20ALPHA-HYDROXY-PROGESTERONE;MUTAGENESIS OF GLU-127; HIS-222; ARG-304; TYR-305; THR-307 AND ASP-309
    14. 14.
      "Probing the inhibitor selectivity pocket of human 20alpha-hydroxysteroid dehydrogenase (AKR1C1) with X-ray crystallography and site-directed mutagenesis."
      El-Kabbani O. , Dhagat U. , Soda M. , Endo S. , Matsunaga T. , Hara A.
      Bioorg. Med. Chem. Lett.21:2564-2567(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.87 ANGSTROMS) IN COMPLEX WITH NADP AND 3-CHLORO-5-PHENYLSALICYLIC ACID
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