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Index > Protein center > ALDH3A1(Gene name) > Human
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  • ALDH3A1 (Gene name),
  • Aldehyde dehydrogenase, dimeric NADP-preferring (Protein name ),  AL3A1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Gene name:
    ALDH3A1(ALDH3);
    Protein name:
    Aldehyde dehydrogenase, dimeric NADP-preferring;
    Alternative:
    Aldehyde dehydrogenase 3;ALDHIII;Aldehyde dehydrogenase family 3 member A1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer.
    Function:
    ALDHs play a major role in the detoxification of alcohol-derived acetaldehyde. They are involved in the metabolism of corticosteroids, biogenic amines, neurotransmitters, and lipid peroxidation. This protein preferentially oxidizes aromatic aldehyde substrates. It may play a role in the oxidation of toxic aldehydes.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    453
    Sequence:
    50:
    MSKISEAVKR | ARAAFSSGRT | RPLQFRIQQL | EALQRLIQEQ | EQELVGALAA | 
    100:
    DLHKNEWNAY | YEEVVYVLEE | IEYMIQKLPE | WAADEPVEKT | PQTQQDELYI | 
    150:
    HSEPLGVVLV | IGTWNYPFNL | TIQPMVGAIA | AGNSVVLKPS | ELSENMASLL | 
    200:
    ATIIPQYLDK | DLYPVINGGV | PETTELLKER | FDHILYTGST | GVGKIIMTAA | 
    250:
    AKHLTPVTLE | LGGKSPCYVD | KNCDLDVACR | RIAWGKFMNS | GQTCVAPDYI | 
    300:
    LCDPSIQNQI | VEKLKKSLKE | FYGEDAKKSR | DYGRIISARH | FQRVMGLIEG | 
    350:
    QKVAYGGTGD | AATRYIAPTI | LTDVDPQSPV | MQEEIFGPVL | PIVCVRSLEE | 
    400:
    AIQFINQREK | PLALYMFSSN | DKVIKKMIAE | TSSGGVAAND | VIVHITLHSL | 
    450:
    PFGGVGNSGM | GSYHGKKSFE | TFSHRRSCLV | RPLMNDEGLK | VRYPPSPAKM | 
    453:
    TQH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    Pfam:
    KEGG:
    SMR:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
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    E11318h
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    ELISA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
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    E11318r
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    ELISA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
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    ELISA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
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    ELISA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
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    CLIA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
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    U11318d
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    CLIA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
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    U11318m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
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    U11318r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Cat.:
    U11318h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Aldehyde dehydrogenase, dimeric NADP-preferring
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    Polyclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Cat.:
    P11318Rb-h
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    40ug/0.2ml
    Polyclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Cat.:
    P11318Rb-m
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    Packing:
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    Polyclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Polyclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Polyclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Cat.:
    P11318Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Monoclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Monoclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Monoclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Monoclonal Antibody for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Protein for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Protein for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Protein for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Protein for Human Aldehyde dehydrogenase, dimeric NADP-preferring
    Protein for Human Aldehyde dehydrogenase, dimeric NADP-preferring

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and complete nucleotide sequence of a cDNA encoding the full-length open reading frame of the human aldehyde dehydrogenase type III gene."
      Schuuring E.M.D. , Verhoeven E. , Eckey R. , Vos H.L. , Michalides R.J.A.
      Submitted (1991-08) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ALA-134
      tissue: Stomach.
    2. 2.
      "Human stomach aldehyde dehydrogenase cDNA and genomic cloning, primary structure, and expression in Escherichia coli."
      Hsu L.C. , Chang W.-C. , Shibuya A. , Yoshida A.
      J. Biol. Chem.267:3030-3037(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Stomach.
    3. 3.
      "Human stomach aldehyde dehydrogenase, ALDH3."
      Hsu L.C. , Yoshida A.
      Adv. Exp. Med. Biol.328:141-152(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Stomach.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-134
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-134
      tissue: Cervix.
      tissue: Tongue.
    6. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ALA-134
    7. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ALA-134
      tissue: Pancreas.
    8. 9.
      "Structural features of stomach aldehyde dehydrogenase distinguish dimeric aldehyde dehydrogenase as a 'variable' enzyme. 'Variable' and 'constant' enzymes within the alcohol and aldehyde dehydrogenase families."
      Yin S.-J. , Vagelopoulos N. , Wang S.-L. , Joernvall H.
      FEBS Lett.283:85-88(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 62-453
      tissue: Stomach.
    9. 10.
      "Biochemical, immunological, and molecular characterization of a 'high Km' aldehyde dehydrogenase."
      Eckey R. , Timmann R. , Hempel J. , Agarwal D.P. , Goedde H.W.
      Adv. Exp. Med. Biol.284:43-52(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    10. 11.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-178 AND LYS-194;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    13. 14.
      "Discovery of a novel class of covalent inhibitor for aldehyde dehydrogenases."
      Khanna M. , Chen C.H. , Kimble-Hill A. , Parajuli B. , Perez-Miller S. , Baskaran S. , Kim J. , Dria K. , Vasiliou V. , Mochly-Rosen D. , Hurley T.D.
      J. Biol. Chem.286:43486-43494(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.48 ANGSTROMS) IN COMPLEX WITH INHIBITOR;MUTAGENESIS OF CYS-244;ACTIVE SITE
    14. 15.
      "Mutations associated with Sjogren-Larsson syndrome."
      Tsukamoto N. , Chang C. , Yoshida A.
      Ann. Hum. Genet.61:235-242(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ALA-329
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