AKR1B1 ELISA Kit for Human(Homo sapiens) | EIAab.comAKR1B1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > AKR1B1(Gene name) > Human

AKR1B1 (Gene name),

Aldose reductase (Protein name ), ALDR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

AKR1B1(ALDR1);

Protein name:

Aldose reductase(AR);

Alternative:

Aldo-keto reductase family 1 member B1;Aldehyde reductase;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

316

Sequence:

50:

100:

150:

200:

250:

300:

316:

LLSCTSHKDY | PFHEEF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000285930

String:

P15121

MIM:

103880

UniGene:

Hs.521212

SMR:

P15121

Pfam:

PF00248

KEGG:

hsa:231

Uniprot:

P15121

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ELISA Kit for Human AR

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E2220r

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96T

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ELISA Kit for Human AR

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E2220p

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96T

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ELISA Kit for Human AR

Cat.:

E2220h

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96T

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ELISA Kit for Human AR

Cat.:

E2220m

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96T

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ELISA Kit for Human AR

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ELISA Kit for Human AR

Cat.:

E2220b

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96T

CLIA Kit for Human AR

Cat.:

U2220h

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96T

CLIA Kit for Human AR

Cat.:

U2220r

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96T

CLIA Kit for Human AR

Cat.:

U2220m

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Packing:

96T

CLIA Kit for Human AR

Cat.:

U2220p

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MSDS:

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Packing:

96T

CLIA Kit for Human AR

MSDS:

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CLIA Kit for Human AR

Cat.:

U2220b

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96T

Polyclonal Antibody for Human AR

Cat.:

P2220Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human AR

Cat.:

P2220Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human AR

Cat.:

P2220Rb-h

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Polyclonal Antibody for Human AR

Monoclonal Antibody for Human AR

Protein for Human AR

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases."
Bohren K.M. , Bullock B. , Wermuth B. , Gabbay K.H.
J. Biol. Chem.264:9547-9551(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
2.

"Cloning and sequence determination of human placental aldose reductase gene."
Chung S. , Lamendola J.
J. Biol. Chem.264:14775-14777(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Placenta.
3.

"Nucleotide sequence of cDNA for human aldose reductase."
Graham A. , Hedge P.J. , Powell S.J. , Riley J. , Brown L. , Gammack A. , Carey F. , Markham A.F.
Nucleic Acids Res.17:8368-8368(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fetus.
4.

"Cloning and prokaryotic expression of a biologically active human placental aldose reductase."
Grundmann U. , Bohn H. , Obermeier R. , Amann E.
DNA Cell Biol.9:149-157(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue: Placenta.
5.

"Cloning and expression of human aldose reductase."
Nishimura C. , Matsuura Y. , Kokai Y. , Akera T. , Carper D. , Morjana N. , Lyons C. , Flynn T.G.
J. Biol. Chem.265:9788-9792(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

"Structure of the human aldose reductase gene."
Graham A. , Brown L. , Hedge P.J. , Gammack A.J. , Markham A.F.
J. Biol. Chem.266:6872-6877(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene."
Ko B.C.B. , Ruepp B. , Bohren K.M. , Gabbay K.H. , Chung S.S.
J. Biol. Chem.272:16431-16437(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
8.

"SEREX identification of new tumour-associated antigens in cutaneous T-cell lymphoma."
Hartmann T.B. , Thiel D. , Dummer R. , Schadendorf D. , Eichmueller S.
Br. J. Dermatol.150:252-258(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Lymphoma.
9.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain cortex.
10.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
11.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2004-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
12.

"Human chromosome 7: DNA sequence and biology."
Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
13.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
14.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
tissue: Eye.
tissue: Urinary bladder.
15.

"Aldose reductase is involved in long-term adaptation of EUE cells to hyperosmotic stress."
Ferraretto A. , Negri A. , Giuliani A. , De Grada L. , Fuhrman Conti A.M. , Ronchi S.
Biochim. Biophys. Acta1175:283-288(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 131-162;TISSUE SPECIFICITY
16.

"Aldose reductase from human psoas muscle. Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine."
Morjana N.A. , Lyons C. , Flynn T.G.
J. Biol. Chem.264:2912-2919(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 244-275
17.

Lubec G. , Vishwanath V.
Submitted (2007-03) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 276-294;IDENTIFICATION BY MASS SPECTROMETRY
tissue: Brain.
tissue: Cajal-Retzius cell.
18.

"Identification of the reactive cysteine residue in human placenta aldose reductase."
Liu S.Q. , Bhatnagar A. , Ansari N.H. , Srivastava S.K.
Biochim. Biophys. Acta1164:268-272(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 298-316;ENZYME REGULATION
19.

"Sequence of pig lens aldose reductase and electrospray mass spectrometry of non-covalent and covalent complexes."
Jaquinod M. , Potier N. , Klarskov K. , Reymann J.-M. , Sorokine O. , Kieffer S. , Barth P. , Andriantomanga V. , Biellmann J.-F. , van Dorsselaer A.
Eur. J. Biochem.218:893-903(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;ACETYLATION AT ALA-2
tissue: Muscle.
20.

"Probing the active site of human aldose reductase. Site-directed mutagenesis of Asp-43, Tyr-48, Lys-77, and His-110."
Tarle I. , Borhani D.W. , Wilson D.K. , Quiocho F.A. , Petrash J.M.
J. Biol. Chem.268:25687-25693(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ASP-44; TYR-49; LYS-78 AND HIS-111
21.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
22.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-95; LYS-222 AND LYS-263;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
23.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.

"An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications."
Wilson D.K. , Bohren K.M. , Gabbay K.H. , Quiocho F.A.
Science257:81-84(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS)
25.

"The crystal structure of the aldose reductase.NADPH binary complex."
Borhani D.W. , Harter T.M. , Pertrash J.M.
J. Biol. Chem.267:24841-24847(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.27 ANGSTROMS)
26.

"Refined 1.8-A structure of human aldose reductase complexed with the potent inhibitor zopolrestat."
Wilson D.K. , Tarle I. , Petrash J.M. , Quiocho F.A.
Proc. Natl. Acad. Sci. U.S.A.90:9847-9851(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS)
27.

"The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant."
Harrison D.H. , Bohren K.M. , Petsko G.A. , Ringe D. , Gabbay K.H.
Biochemistry36:16134-16140(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS)
28.

"The crystallographic structure of the aldose reductase-IDD552 complex shows direct proton donation from tyrosine 48."
Ruiz F. , Hazemann I. , Mitschler A. , Joachimiak A. , Schneider T. , Karplus M. , Podjarny A.
Acta Crystallogr. D60:1347-1354(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.0 ANGSTROMS) IN COMPLEX WITH NADP AND SYNTHETIC INHIBITOR;ACTIVE SITE
29.

"Ultrahigh resolution drug design I: details of interactions in human aldose reductase-inhibitor complex at 0.66 A."
Howard E.I. , Sanishvili R. , Cachau R.E. , Mitschler A. , Chevrier B. , Barth P. , Lamour V. , Van Zandt M. , Sibley E. , Bon C. , Moras D. , Schneider T.R. , Joachimiak A. , Podjarny A.
Proteins55:792-804(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.66 ANGSTROMS) IN COMPLEX WITH NADP AND SYNTHETIC INHIBITOR
30.

"High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group."
Steuber H. , Zentgraf M. , Podjarny A. , Heine A. , Klebe G.
J. Mol. Biol.356:45-56(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.95 ANGSTROMS) IN COMPLEX WITH NADP AND SUBSTRATE ANALOG
31.

"The atomic resolution structure of human aldose reductase reveals that rearrangement of a bound ligand allows the opening of the safety-belt loop."
Biadene M. , Hazemann I. , Cousido A. , Ginell S. , Joachimiak A. , Sheldrick G.M. , Podjarny A. , Schneider T.R.
Acta Crystallogr. D63:665-672(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.82 ANGSTROMS) IN COMPLEX WITH NADP
32.

"Evidence for a novel binding site conformer of aldose reductase in ligand-bound state."
Steuber H. , Zentgraf M. , La Motta C. , Sartini S. , Heine A. , Klebe G.
J. Mol. Biol.369:186-197(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) IN COMPLEX WITH NADP AND SYNTHETIC INHIBITOR
33.

"Structural and thermodynamic study on aldose reductase: nitro-substituted inhibitors with strong enthalpic binding contribution."
Steuber H. , Heine A. , Klebe G.
J. Mol. Biol.368:618-638(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.43 ANGSTROMS) IN COMPLEX WITH NADP AND SYNTHETIC INHIBITOR

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