Alkbh1 ELISA Kit for Mouse(Mus musculus) | EIAab.comAlkbh1 ELISA Kit for Mouse(Mus musculus) | EIAab.com

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Alkbh1 (Gene name),

Alkylated DNA repair protein alkB homolog 1 (Protein name ), ALKB1_MOUSE from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

Alkbh1(Abh;Alkbh);

Protein name:

Alkylated DNA repair protein alkB homolog 1;

Alternative:

4.2.99.18;DNA lyase ABH1);Alpha-ketoglutarate-dependent dioxygenase ABH1;DNA oxidative demethylase ALKBH1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer (By similarity). Interacts with DNAJB6.

Function:

Dioxygenase that repairs alkylated single-stranded DNA and RNA containing 3-methylcytosine by oxidative demethylation. Requires molecular oxygen, alpha-ketoglutarate and iron. Has DNA lyase activity and introduces double-stranded breaks at abasic sites. Cleaves both single-stranded DNA and double-stranded DNA at abasic sites, with the greatest activity towards double-stranded DNA with two abasic sites. DNA lyase activity does not require alpha-ketoglutarate and iron (By similarity). May have a role in placental trophoblast lineage differentiation.

Subcellular Location:

Nucleus Mitochondrion Mainly localizes in euchromatin, largely excluded from heterochromatin and nucleoli.

Protein Attributes:

Sequence length:

389

Sequence:

50:

MGKMAAAVAS | LATLAAEPRE | DAFRKLFRFY | RQSRPGTADL | GAVIDFSEAH |

100:

LARSPKPGVP | QVVRFPLNVS | SVTERDAERV | GLEPVSKWRA | YGLEGYPGFI |

150:

FIPNPFLPGC | QRHWVKQCLK | LYSQKPNVCN | LDKHMTKEET | QGLWEQSKEV |

200:

LRSKEVTKRR | PRSLLERLRW | VTLGYHYNWD | SKKYSADHYT | PFPSDLAFLS |

250:

EQVATACGFQ | GFQAEAGILN | YYRLDSTLGI | HVDRSELDHS | KPLLSFSFGQ |

300:

SAIFLLGGLK | RDEAPTAMFM | HSGDIMVMSG | FSRLLNHAVP | RVLPHPDGEC |

350:

LPHCLETPLP | AVLPSNSLVE | PCSVEDWQVC | ATYLRTARVN | MTVRQVLATG |

389:

QDFPLEPVEE | TKRDIAADGL | CHLHDPNSPV | KRKRLNPNS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

String:

UniGene:

KEGG:

STRING:

10090.ENSMUSP00000105782

Pfam:

SMR:

Uniprot:

FOR

ELISA Kit for Mouse Alkylated DNA repair protein alkB homolog 1

ELISA Kit for Mouse Alkylated DNA repair protein alkB homolog 1

CLIA Kit for Mouse Alkylated DNA repair protein alkB homolog 1

CLIA Kit for Mouse Alkylated DNA repair protein alkB homolog 1

Polyclonal Antibody for Mouse Alkylated DNA repair protein alkB homolog 1

Polyclonal Antibody for Mouse Alkylated DNA repair protein alkB homolog 1

Monoclonal Antibody for Mouse Alkylated DNA repair protein alkB homolog 1

Monoclonal Antibody for Mouse Alkylated DNA repair protein alkB homolog 1

Protein for Mouse Alkylated DNA repair protein alkB homolog 1

Protein for Mouse Alkylated DNA repair protein alkB homolog 1

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Precision

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Recovery

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Linearity

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice."
Pan Z. , Sikandar S. , Witherspoon M. , Dizon D. , Nguyen T. , Benirschke K. , Wiley C. , Vrana P. , Lipkin S.M.
Dev. Dyn.237:316-327(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DNAJB6;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE

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