ALKBH3 ELISA Kit for Human(Homo sapiens) | EIAab.comALKBH3 ELISA Kit for Human(Homo sapiens)

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ALKBH3 (Gene name),

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 (Protein name ), ALKB3_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ALKBH3(ABH3;DEPC1);

Protein name:

Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3;

Alternative:

DEPC-1;Alkylated DNA repair protein alkB homolog 3;Prostate cancer antigen 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Dioxygenase that repairs alkylated DNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Has a strong preference for single-stranded DNA. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

286

Sequence:

50:

100:

150:

200:

250:

286:

TQADWQHRVP | KEYHSREPRV | NLTFRTVYPD | PRGAPW

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

610603

Pfam:

PF03171

STRING:

9606.ENSP00000302232

KEGG:

hsa:221120

UniGene:

Hs.720708

String:

Q96Q83

Pfam:

PF13532

SMR:

Q96Q83

Uniprot:

Q96Q83

FOR

ELISA Kit for Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

CLIA Kit for Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Polyclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Monoclonal Antibody for Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

Protein for Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Homo sapiens mRNA expressed in prostate cancer and thymus."
Tsujikawa K. , Konishi N. , Ono Y. , Ichijou T. , Sakamoto K. , Yamamoto H.
Submitted (2000-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Fetal thymus.
tissue: Prostatic carcinoma.
2.

NIEHS SNPs program
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CYS-164 AND GLU-228
3.

"Human chromosome 11 DNA sequence and analysis including novel gene identification."
Taylor T.D. , Noguchi H. , Totoki Y. , Toyoda A. , Kuroki Y. , Dewar K. , Lloyd C. , Itoh T. , Takeda T. , Kim D.-W. , She X. , Barlow K.F. , Bloom T. , Bruford E. , Chang J.L. , Cuomo C.A. , Eichler E. , FitzGerald M.G. , more...
Nature440:497-500(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT GLU-228
tissue: Lung.
tissue: PNS.
6.

"Reversal of DNA alkylation damage by two human dioxygenases."
Duncan T. , Trewick S.C. , Koivisto P. , Bates P.A. , Lindahl T. , Sedgwick B.
Proc. Natl. Acad. Sci. U.S.A.99:16660-16665(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.

"Human and bacterial oxidative demethylases repair alkylation damage in both RNA and DNA."
Aas P.A. , Otterlei M. , Falnes P.O. , Vaagboe C.B. , Skorpen F. , Akbari M. , Sundheim O. , Bjoeraas M. , Slupphaug G. , Seeberg E. , Krokan H.E.
Nature421:859-863(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
8.

"Repair of methylation damage in DNA and RNA by mammalian AlkB homologues."
Lee D.-H. , Jin S.-G. , Cai S. , Chen Y. , Pfeifer G.P. , O'Connor T.R.
J. Biol. Chem.280:39448-39459(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-193 AND HIS-257;TISSUE SPECIFICITY
9.

"Expression and sub-cellular localization of human ABH family molecules."
Tsujikawa K. , Koike K. , Kitae K. , Shinkawa A. , Arima H. , Suzuki T. , Tsuchiya M. , Makino Y. , Furukawa T. , Konishi N. , Yamamoto H.
J. Cell. Mol. Med.11:1105-1116(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
10.

"DNA unwinding by ASCC3 helicase is coupled to ALKBH3-dependent DNA alkylation repair and cancer cell proliferation."
Dango S. , Mosammaparast N. , Sowa M.E. , Xiong L.J. , Wu F. , Park K. , Rubin M. , Gygi S. , Harper J.W. , Shi Y.
Mol. Cell44:373-384(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;INTERACTION WITH ALKBH3;MUTAGENESIS OF HIS-257
11.

"Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage."
Sundheim O. , Vaagboe C.B. , Bjoeraas M. , Sousa M.M.L. , Talstad V. , Aas P.A. , Drabloes F. , Krokan H.E. , Tainer J.A. , Slupphaug G.
EMBO J.25:3389-3397(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.5 ANGSTROMS) OF 70-286 IN COMPLEX WITH ALPHA-KETOGLUTARATE AND IRON;IDENTIFICATION BY MASS SPECTROMETRY;HYDROXYLATION AT LEU-177;OXIDATION AT LEU-177

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