ALK ELISA Kit for Human(Homo sapiens) | EIAab.comALK ELISA Kit for Human(Homo sapiens)

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ALK (Gene name),

ALK tyrosine kinase receptor (Protein name ), ALK_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ALK;

Protein name:

ALK tyrosine kinase receptor;

Alternative:

Anaplastic lymphoma kinase;

CD:

CD246;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Homodimerizes when bound to ligand. Interacts with FRS2, IRS1, MDK, PTN and SHC1. Interacts with CBL, PIK3R1 and PLCG1.

Function:

Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.

Protein Attributes:

Sequence length:

1620

Sequence:

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1150:

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1250:

1300:

1350:

1400:

1450:

1500:

1550:

1600:

1620:

AGHYEDTILK | SKNSMNQPGP |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9UM73

KEGG:

hsa:238

UniGene:

Hs.654469

STRING:

9606.ENSP00000373700

MIM:

105590

String:

Q9UM73

Pfam:

PF00629

Uniprot:

Q9UM73

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ELISA Kit for Human ALK tyrosine kinase receptor

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E1113h

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96T

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ELISA Kit for Human ALK tyrosine kinase receptor

Cat.:

E1113m

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Packing:

96T

CLIA Kit for Human ALK tyrosine kinase receptor

Cat.:

U1113h

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Packing:

96T

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CLIA Kit for Human ALK tyrosine kinase receptor

Cat.:

U1113m

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Packing:

96T

Polyclonal Antibody for Human ALK tyrosine kinase receptor

Cat.:

P1113Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human ALK tyrosine kinase receptor

Cat.:

P1113Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human ALK tyrosine kinase receptor

Protein for Human ALK tyrosine kinase receptor

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"ALK, the chromosome 2 gene locus altered by the t(2;5) in non-Hodgkin's lymphoma, encodes a novel neural receptor tyrosine kinase that is highly related to leukocyte tyrosine kinase (LTK)."
Morris S.W. , Naeve C.W. , Mathew P. , James P.L. , Kirstein M.N. , Cui X. , Witte D.P.
Oncogene14:2175-2188(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY;GLYCOSYLATION;VARIANT VAL-1461
2.

Morris S.W. , Naeve C.W. , Mathew P. , James P.L. , Kirstein M.N. , Cui X. , Witte D.P.
Oncogene15:2883-2883(1997)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
3.

"Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system."
Iwahara T. , Fujimoto J. , Wen D. , Cupples R. , Bucay N. , Arakawa T. , Mori S. , Ratzkin B. , Yamamoto T.
Oncogene14:439-449(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS VAL-1461; ARG-1491 AND GLU-1529
4.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS VAL-1461; ARG-1491 AND GLU-1529
tissue: Brain.
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma."
Morris S.W. , Kirstein M.N. , Valentine M.B. , Dittmer K.G. , Shapiro D.N. , Saltman D.L. , Look A.T.
Science263:1281-1284(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA];CHROMOSOMAL TRANSLOCATION WITH NPM1;VARIANT VAL-1461
7.

"The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation."
Simonitsch I. , Polgar D. , Hajek M. , Duchek P. , Skrzypek B. , Fassl S. , Lamprecht A. , Schmidt G. , Krupitza G. , Cerni C.
FASEB J.15:1416-1418(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS AN ONCOGENE
8.

"Activation of anaplastic lymphoma kinase receptor tyrosine kinase induces neuronal differentiation through the mitogen-activated protein kinase pathway."
Souttou B. , Carvalho N.B. , Raulais D. , Vigny M.
J. Biol. Chem.276:9526-9531(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;FUNCTION
9.

"Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin."
Stoica G.E. , Kuo A. , Aigner A. , Sunitha I. , Souttou B. , Malerczyk C. , Caughey D.J. , Wen D. , Karavanov A. , Riegel A.T. , Wellstein A.
J. Biol. Chem.276:16772-16779(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PTN;FUNCTION
10.

"Identification of novel fusion partners of ALK, the anaplastic lymphoma kinase, in anaplastic large-cell lymphoma and inflammatory myofibroblastic tumor."
Cools J. , Wlodarska I. , Somers R. , Mentens N. , Pedeutour F. , Maes B. , De Wolf-Peeters C. , Pauwels P. , Hagemeijer A. , Marynen P.
Genes Chromosomes Cancer34:354-362(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH ALO17 AND CARS
11.

"Pleiotrophin signaling through anaplastic lymphoma kinase is rate-limiting for glioblastoma growth."
Powers C. , Aigner A. , Stoica G.E. , McDonnell K. , Wellstein A.
J. Biol. Chem.277:14153-14158(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"Anti-apoptotic signaling of pleiotrophin through its receptor, anaplastic lymphoma kinase."
Bowden E.T. , Stoica G.E. , Wellstein A.
J. Biol. Chem.277:35862-35868(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
13.

"Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types."
Stoica G.E. , Kuo A. , Powers C. , Bowden E.T. , Sale E.B. , Riegel A.T. , Wellstein A.
J. Biol. Chem.277:35990-35998(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MDK;FUNCTION
14.

"ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth."
Motegi A. , Fujimoto J. , Kotani M. , Sakuraba H. , Yamamoto T.
J. Cell Sci.117:3319-3329(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBL; IRS1; PIK3R1; PLCG1 AND SHC1;FUNCTION IN PHOSPHORYLATION OF CBL; IRS1 AND SHC1
15.

"Unique substrate specificity of anaplastic lymphoma kinase (ALK): development of phosphoacceptor peptides for the assay of ALK activity."
Donella-Deana A. , Marin O. , Cesaro L. , Gunby R.H. , Ferrarese A. , Coluccia A.M. , Tartari C.J. , Mologni L. , Scapozza L. , Gambacorti-Passerini C. , Pinna L.A.
Biochemistry44:8533-8542(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBSTRATE SPECIFICITY;PHOSPHORYLATION AT TYR-1278
16.

"Differential induction of glioblastoma migration and growth by two forms of pleiotrophin."
Lu K.V. , Jong K.A. , Kim G.Y. , Singh J. , Dia E.Q. , Yoshimoto K. , Wang M.Y. , Cloughesy T.F. , Nelson S.F. , Mischel P.S.
J. Biol. Chem.280:26953-26964(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN GLIOBLASTOMA
17.

"Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells."
Gouzi J.Y. , Moog-Lutz C. , Vigny M. , Brunet-de Carvalho N.
J. Cell Sci.118:5811-5823(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT;ENZYME REGULATION;FUNCTION
18.

"Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1078; TYR-1096; TYR-1131 AND TYR-1604;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.

"Fusion of the SEC31L1 and ALK genes in an inflammatory myofibroblastic tumor."
Panagopoulos I. , Nilsson T. , Domanski H.A. , Isaksson M. , Lindblom P. , Mertens F. , Mandahl N.
Int. J. Cancer118:1181-1186(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHROMOSOMAL TRANSLOCATION WITH SEC31A
20.

"ALK activation induces Shc and FRS2 recruitment: Signaling and phenotypic outcomes in PC12 cells differentiation."
Degoutin J. , Vigny M. , Gouzi J.Y.
FEBS Lett.581:727-734(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FRS2 AND SHC1;PHOSPHORYLATION AT TYR-1507;MUTAGENESIS OF TYR-1507;FUNCTION IN PHOSPHORYLATION OF FRS2; MAPK1/ERK2; MAPK3/ERK1 AND SHC1
21.

"Anaplastic lymphoma kinase is activated through the pleiotrophin/receptor protein-tyrosine phosphatase beta/zeta signaling pathway: an alternative mechanism of receptor tyrosine kinase activation."
Perez-Pinera P. , Zhang W. , Chang Y. , Vega J.A. , Deuel T.F.
J. Biol. Chem.282:28683-28690(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;ENZYME REGULATION
22.

"Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase."
Kuo A.H. , Stoica G.E. , Riegel A.T. , Wellstein A.
Oncogene26:859-869(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRS1 AND SHC;PHOSPHORYLATION AT TYR-1096;FUNCTION
23.

"Anaplastic lymphoma kinase: signalling in development and disease."
Palmer R.H. , Vernersson E. , Grabbe C. , Hallberg B.
Biochem. J.420:345-361(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION
24.

"Solution structure of the complex of the PTB domain of SNT-2 and 19-residue peptide (aa 1571-1589) of HALK."
RIKEN structural genomics initiative (RSGI)
Submitted (2008-04) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1571-1589
25.

"Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain."
Lee C.C. , Jia Y. , Li N. , Sun X. , Ng K. , Ambing E. , Gao M.Y. , Hua S. , Chen C. , Kim S. , Michellys P.Y. , Lesley S.A. , Harris J.L. , Spraggon G.
Biochem. J.430:425-437(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1072-1410
26.

"Crystal structures of anaplastic lymphoma kinase in complex with ATP competitive inhibitors."
Bossi R.T. , Saccardo M.B. , Ardini E. , Menichincheri M. , Rusconi L. , Magnaghi P. , Orsini P. , Avanzi N. , Borgia A.L. , Nesi M. , Bandiera T. , Fogliatto G. , Bertrand J.A.
Biochemistry49:6813-6825(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF 1094-1407 IN COMPLEX WITH INHIBITOR
27.

"Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2."
Koshiba S. , Li H. , Motoda Y. , Tomizawa T. , Kasai T. , Tochio N. , Yabuki T. , Harada T. , Watanabe S. , Tanaka A. , Shirouzu M. , Kigawa T. , Yamamoto T. , Yokoyama S.
J. Struct. Funct. Genomics11:125-141(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1571-1589
28.

"Structure of L1196M mutant anaplastic lymphoma kinase in complex with crizotinib."
Mctigue M. , Deng Y. , Liu W. , Brooun A.
Submitted (2011-05) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.70 ANGSTROMS) OF 1093-1411 IN COMPLEX WITH CRIZOTINIB
29.

"CH5424802, a selective ALK inhibitor capable of blocking the resistant gatekeeper mutant."
Sakamoto H. , Tsukaguchi T. , Hiroshima S. , Kodama T. , Kobayashi T. , Fukami T.A. , Oikawa N. , Tsukuda T. , Ishii N. , Aoki Y.
Cancer Cell19:679-690(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF 1069-1411 IN COMPLEX WITH INHIBITOR;ENZYME REGULATION
30.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] LEU-90; LEU-163; GLN-296; ALA-476; PHE-560; ILE-680; THR-704; SER-877; MET-1012; ASP-1121; THR-1274; LEU-1328; ASN-1416; LYS-1419; ARG-1429; ARG-1491 AND GLU-1529
31.

"Identification of ALK as a major familial neuroblastoma predisposition gene."
Mosse Y.P. , Laudenslager M. , Longo L. , Cole K.A. , Wood A. , Attiyeh E.F. , Laquaglia M.J. , Sennett R. , Lynch J.E. , Perri P. , Laureys G. , Speleman F. , Kim C. , Hou C. , Hakonarson H. , Torkamani A. , Schork N.J. , Brodeur G.M. , more...
Nature455:930-935(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NBLST3 ASN-1091; ALA-1128; ARG-1166; ASN-1171; ILE-1174; PRO-1192; CYS-1245; VAL-1245 THR-1250 AND GLN-1275
32.

"Somatic and germline activating mutations of the ALK kinase receptor in neuroblastoma."
Janoueix-Lerosey I. , Lequin D. , Brugieres L. , Ribeiro A. , de Pontual L. , Combaret V. , Raynal V. , Puisieux A. , Schleiermacher G. , Pierron G. , Valteau-Couanet D. , Frebourg T. , Michon J. , Lyonnet S. , Amiel J. , Delattre O.
Nature455:967-970(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NBLST3 VAL-1174; LEU-1174; CYS-1174; PRO-1192; GLN-1275 AND SER-1278;VARIANT LEU-1275
33.

"Activating mutations in ALK provide a therapeutic target in neuroblastoma."
George R.E. , Sanda T. , Hanna M. , Froehling S. , Luther W. II , Zhang J. , Ahn Y. , Zhou W. , London W.B. , McGrady P. , Xue L. , Zozulya S. , Gregor V.E. , Webb T.R. , Gray N.S. , Gilliland D.G. , Diller L. , Greulich H. , more...
Nature455:975-978(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NBLST3 MET-1151; LEU-1174; THR-1234; CYS-1245 AND GLN-1275
34.

"The constitutive activity of the ALK mutated at positions F1174 or R1275 impairs receptor trafficking."
Mazot P. , Cazes A. , Boutterin M.C. , Figueiredo A. , Raynal V. , Combaret V. , Hallberg B. , Palmer R.H. , Delattre O. , Janoueix-Lerosey I. , Vigny M.
Oncogene30:2017-2025(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS NBLST3 LEU-1174; VAL-1174 AND GLN-1275

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