Alk ELISA Kit for Mouse(Mus musculus) | EIAab.comAlk ELISA Kit for Mouse(Mus musculus)

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Alk (Gene name),

ALK tyrosine kinase receptor (Protein name ), ALK_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Alk;

Protein name:

ALK tyrosine kinase receptor;

Alternative:

Anaplastic lymphoma kinase;

CD:

CD246;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homodimer. Homodimerizes when bound to ligand (By similarity). Interacts with CBL, IRS1, PIK3R1, PLCG1 and SHC1. Interacts with FRS2, PTN and MDK.

Function:

Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.

Protein Attributes:

Sequence length:

1621

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1621:

ATAAPGDTML | KSKNKVTQPG | P

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.311854

String:

P97793

STRING:

10090.ENSMUSP00000083840

KEGG:

mmu:11682

SMR:

P97793

Pfam:

PF00629

Uniprot:

P97793

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ELISA Kit for Mouse ALK tyrosine kinase receptor

Cat.:

E1113h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Mouse ALK tyrosine kinase receptor

Cat.:

E1113m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse ALK tyrosine kinase receptor

Cat.:

U1113h

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

Range:

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CLIA Kit for Mouse ALK tyrosine kinase receptor

Cat.:

U1113m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse ALK tyrosine kinase receptor

Cat.:

P1113Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse ALK tyrosine kinase receptor

Cat.:

P1113Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse ALK tyrosine kinase receptor

Protein for Mouse ALK tyrosine kinase receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular characterization of ALK, a receptor tyrosine kinase expressed specifically in the nervous system."
Iwahara T. , Fujimoto J. , Wen D. , Cupples R. , Bucay N. , Arakawa T. , Mori S. , Ratzkin B. , Yamamoto T.
Oncogene14:439-449(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
tissue: Testis.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth."
Motegi A. , Fujimoto J. , Kotani M. , Sakuraba H. , Yamamoto T.
J. Cell Sci.117:3319-3329(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION;INTERACTION WITH CBL; IRS1; PIK3R1; PLCG1 AND SHC1;FUNCTION IN PHOSPHORYLATION OF CBL; IRS1 AND SHC1
4.

"Characterization of the expression of the ALK receptor tyrosine kinase in mice."
Vernersson E. , Khoo N.K. , Henriksson M.L. , Roos G. , Palmer R.H. , Hallberg B.
Gene Expr. Patterns6:448-461(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;FUNCTION
5.

"Recruitment of insulin receptor substrate-1 and activation of NF-kappaB essential for midkine growth signaling through anaplastic lymphoma kinase."
Kuo A.H. , Stoica G.E. , Riegel A.T. , Wellstein A.
Oncogene26:859-869(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IRS1 AND SHC;PHOSPHORYLATION AT TYR-1096;FUNCTION
6.

"ALK (Anaplastic Lymphoma Kinase) expression in DRG neurons and its involvement in neuron-Schwann cells interaction."
Degoutin J. , Brunet-de Carvalho N. , Cifuentes-Diaz C. , Vigny M.
Eur. J. Neurosci.29:275-286(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Anaplastic lymphoma kinase: signalling in development and disease."
Palmer R.H. , Vernersson E. , Grabbe C. , Hallberg B.
Biochem. J.420:345-361(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON FUNCTION

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