Gene name:
    AMBRA1 (KIAA1736) ;
    
 
    Protein name:
    Activating molecule in BECN1-regulated autophagy protein 1 ;
    
    Alternative:
    
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Sub Unit:
    Interacts with BECN1. Probably forms a complex with BECN1 and PIK3C3.
    
 
    Function:
    Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Cytoplasmic vesicle  
      autophagosome 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MKVVPEKNAV |  RILWGRERGA |  RAMGAQRLLQ |  ELVEDKTRWM |  KWEGKRVELP |  
    
 
    100:
    DSPRSTFLLA |  FSPDRTLLAS |  THVNHNIYIT |  EVKTGKCVHS |  LIGHRRTPWC |  
    
 
    150:
    VTFHPTISGL |  IASGCLDGEV |  RIWDLHGGSE |  SWFTDSNNAI |  ASLAFHPTAQ |  
    
 
    200:
    LLLIATANEI |  HFWDWSRREP |  FAVVKTASEM |  ERVRLVRFDP |  LGHYLLTAIV |  
    
 
    250:
    NPSNQQGDDE |  PEIPIDGTEL |  SHYRQRALLQ |  SQPVRRTPLL |  HNFLHMLSSR |  
    
 
    300:
    SSGIQVGEQS |  TVQDSATPSP |  PPPPPQPSTE |  RPRTSAYIRL |  RQRVSYPTAE |  
    
 
    350:
    CCQHLGILCL |  CSRCSGTRVP |  SLLPHQDSVP |  PASARATTPS |  FSFVQTEPFH |  
    
 
    400:
    PPEQASSTQQ |  DQGLLNRPSA |  FSTVQSSTAG |  NTLRNLSLGP |  TRRSLGGPLS |  
    
 
    450:
    SHPSRYHREI |  APGLTGSEWT |  RTVLSLNSRS |  EAESMPPPRT |  SASSVSLLSV |  
    
 
    500:
    LRQQEGGSQA |  SVYTSATEGR |  GFPASGLATE |  SDGGNGSSQN |  NSGSIRHELQ |  
    
 
    550:
    CDLRRFFLEY |  DRLQELDQSL |  SGEAPQTQQA |  QEMLNNNIES |  ERPGPSHQPT |  
    
 
    600:
    PHSSENNSNL |  SRGHLNRCRA |  CHNLLTFNND |  TLRWERTTPN |  YSSGEASSSW |  
    
 
    650:
    QVPSSFESVP |  SSGSQLPPLE |  RTEGQTPSSS |  RLELSSSASP |  QEERTVGVAF |  
    
 
    700:
    NQETGHWERI |  YTQSSRSGTV |  SQEALHQDMP |  EESSEEDSLR |  RRLLESSLIS |  
    
 
    750:
    LSRYDGAGSR |  EHPIYPDPAR |  LSPAAYYAQR |  MIQYLSRRDS |  IRQRSMRYQQ |  
    
 
    800:
    NRLRSSTSSS |  SSDNQGPSVE |  GTDLEFEDFE |  DNGDRSRHRA |  PRNARMSAPS |  
    
 
    850:
    LGRFVPRRFL |  LPEYLPYAGI |  FHERGQPGLA |  THSSVNRVLA |  GAVIGDGQSA |  
    
 
    900:
    VASNIANTTY |  RLQWWDFTKF |  DLPEISNASV |  NVLVQNCKIY |  NDASCDISAD |  
    
 
    950:
    GQLLAAFIPS |  SQRGFPDEGI |  LAVYSLAPHN |  LGEMLYTKRF |  GPNAISVSLS |  
    
 
    1000:
    PMGRYVMVGL |  ASRRILLHPS |  TEHMVAQVFR |  LQQAHGGETS |  MRRVFNVLYP |  
    
 
    1050:
    MPADQRRHVS |  INSARWLPEP |  GLGLAYGTNK |  GDLVICRPEA |  LNSGVEYYWD |  
    
 
    1100:
    QLNETVFTVH |  SNSRSSERPG |  TSRATWRTDR |  DMGLMNAIGL |  QPRNPATSVT |  
    
 
    1150:
    SQGTQTLALQ |  LQNAETQTER |  EVPEPGTAAS |  GPGEGEGSEY |  GASGEDALSR |  
    
 
    1200:
    IQRLMAEGGM |  TAVVQREQST |  TMASMGGFGN |  NIIVSHRIHR |  SSQTGTEPGA |  
    
 
    1250:
    AHTSSPQPST |  SRGLLPEAGQ |  LAERGLSPRT |  ASWDQPGTPG |  REPTQPTLPS |  
    
 
    1298:
    SSPVPIPVSL |  PSAEGPTLHC |  ELTNNNHLLD |  GGSSRGDAAG |  PRGEPRNR
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Mouse
         
        
     
    
        ELISA Kit for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
    
        Protein for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
    
        Protein for Human Activating molecule in BECN1-regulated autophagy protein 1
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Precision
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
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                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3) 
                    
                    
                    tissue :
                    
Brain .  
             
         
            
        
            
                2.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2) 
                    
                    
                    tissue :
                    
Brain .  
             
         
            
        
            
                3.
                
                    
                        
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                              more...   
                             
                        
                        
                        
                            Nat. Genet.36:40-45(2004)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 464-1298 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                        
                            "The full-ORF clone resource of the German cDNA consortium." 
                        
                        
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                              more...   
                             
                        
                        
                        
                            BMC Genomics8:399-399(2007)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6) 
                    
                    
                    tissue :
                    
Melanoma .  
             
         
            
        
            
                5.
                
                    
                        
                            "Human chromosome 11 DNA sequence and analysis including novel gene identification." 
                        
                        
                            Taylor T.D. 
                        ,
                            
Noguchi H. 
                        ,
                            
Totoki Y. 
                        ,
                            
Toyoda A. 
                        ,
                            
Kuroki Y. 
                        ,
                            
Dewar K. 
                        ,
                            
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                        ,
                            
Itoh T. 
                        ,
                            
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                        ,
                            
Kim D.-W. 
                        ,
                            
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                        ,
                            
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                        ,
                            
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                        ,
                            
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                        ,
                            
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                        ,
                            
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                        ,
                            
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                        ,
                        
                        
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                        ,
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                        ,
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                        ,
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                        ,
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                        ,
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                        ,
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                              more...   
                             
                        
                        
                        
                            Nature440:497-500(2006)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                        
                        
                            Mural R.J. 
                        ,
                            
Istrail S. 
                        ,
                            
Sutton G.G. 
                        ,
                            
Florea L. 
                        ,
                            
Halpern A.L. 
                        ,
                            
Mobarry C.M. 
                        ,
                            
Lippert R. 
                        ,
                            
Walenz B. 
                        ,
                            
Shatkay H. 
                        ,
                            
Dew I. 
                        ,
                            
Miller J.R. 
                        ,
                            
Flanigan M.J. 
                        ,
                            
Edwards N.J. 
                        ,
                            
Bolanos R. 
                        ,
                            
Fasulo D. 
                        ,
                            
Halldorsson B.V. 
                        ,
                            
Hannenhalli S. 
                        ,
                            
Turner R. 
                        ,
                        
                        
                            Yooseph S. 
                        ,
                            Lu F. 
                        ,
                            Nusskern D.R. 
                        ,
                            Shue B.C. 
                        ,
                            Zheng X.H. 
                        ,
                            Zhong F. 
                        ,
                            Delcher A.L. 
                        ,
                            Huson D.H. 
                        ,
                            Kravitz S.A. 
                        ,
                            Mouchard L. 
                        ,
                            Reinert K. 
                        ,
                            Remington K.A. 
                        ,
                            Clark A.G. 
                        ,
                            Waterman M.S. 
                        ,
                            Eichler E.E. 
                        ,
                            Adams M.D. 
                        ,
                            Hunkapiller M.W. 
                        ,
                            Myers E.W. 
                        ,
                            Venter J.C. 
                        
                             
                              more...   
                             
                        
                        
                            Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
                        
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4) 
                    
                    
                    tissue :
                    
Testis .  
             
         
            
        
            
                8.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                    tissue :
                    
Cervix carcinoma .  
             
         
            
        
            
                9.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                    tissue :
                    
Cervix carcinoma .  
             
         
            
        
            
                10.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                    tissue :
                    
Leukemic T-cell .  
             
         
            
        
            
                11.
                
                    
                        
                            "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis." 
                        
                        
                            Olsen J.V. 
                        ,
                            
Vermeulen M. 
                        ,
                            
Santamaria A. 
                        ,
                            
Kumar C. 
                        ,
                            
Miller M.L. 
                        ,
                            
Jensen L.J. 
                        ,
                            
Gnad F. 
                        ,
                            
Cox J. 
                        ,
                            
Jensen T.S. 
                        ,
                            
Nigg E.A. 
                        ,
                            
Brunak S. 
                        ,
                            
Mann M. 
                        
                        
                        
                        
                            Sci. Signal.3:RA3-RA3(2010)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-639;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                    tissue :
                    
Cervix carcinoma .  
             
         
            
        
            
                12.
                
                    
                        
                            "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB." 
                        
                        
                            Van Damme P. 
                        ,
                            
Lasa M. 
                        ,
                            
Polevoda B. 
                        ,
                            
Gazquez C. 
                        ,
                            
Elosegui-Artola A. 
                        ,
                            
Kim D.S. 
                        ,
                            
De Juan-Pardo E. 
                        ,
                            
Demeyer K. 
                        ,
                            
Hole K. 
                        ,
                            
Larrea E. 
                        ,
                            
Timmerman E. 
                        ,
                            
Prieto J. 
                        ,
                            
Arnesen T. 
                        ,
                            
Sherman F. 
                        ,
                            
Gevaert K. 
                        ,
                            
Aldabe R. 
                        
                        
                        
                        
                            Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS] 
                    
                    
                 
             
         
            
        
            
                13.
                
                    
                        
                            "Beclin 2 functions in autophagy, degradation of G protein-coupled receptors, and metabolism." 
                        
                        
                            He C. 
                        ,
                            
Wei Y. 
                        ,
                            
Sun K. 
                        ,
                            
Li B. 
                        ,
                            
Dong X. 
                        ,
                            
Zou Z. 
                        ,
                            
Liu Y. 
                        ,
                            
Kinch L.N. 
                        ,
                            
Khan S. 
                        ,
                            
Sinha S. 
                        ,
                            
Xavier R.J. 
                        ,
                            
Grishin N.V. 
                        ,
                            
Xiao G. 
                        ,
                            
Eskelinen E.L. 
                        ,
                            
Scherer P.E. 
                        ,
                            
Whistler J.L. 
                        ,
                            
Levine B. 
                        
                        
                        
                        
                            Cell154:1085-1099(2013)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH BECN1P1/BECN2