Ar ELISA Kit for Mouse(Mus musculus) | EIAab.comAr ELISA Kit for Mouse(Mus musculus)

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Ar (Gene name),

Androgen receptor (Protein name ), ANDR_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ar(Nr3c4);

Protein name:

Androgen receptor;

Alternative:

Nuclear receptor subfamily 3 group C member 4;Dihydrotestosterone receptor;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Binds DNA as a homodimer. Part of a ternary complex containing AR, EFCAB6/DJBP and PARK7. Interacts with HIPK3 and NR0B2 in the presence of androgen. The ligand binding domain interacts with KAT7/HBO1 in the presence of dihydrotestosterone. Interacts with EFCAB6/DJBP, PELP1, PQBP1, RANBP9, SPDEF, SRA1, TGFB1I1, ZNF318 and RREB1. The AR N-terminal poly-Gln region binds Ran resulting in enhancement of AR-mediated transactivation. Ran-binding decreases as the poly-Gln length increases. Interacts with ZMIZ1/ZIMP10 and ZMIZ2/ZMIP7 which both enhance its transactivation activity. Interacts with RBAK. Interacts via the ligand-binding domain with LXXLL and FXXLF motifs from NCOA1, NCOA2, NCOA3, NCOA4 and MAGEA11. Interacts with HIP1 (via coiled coil domain) (By similarity). Interacts with SLC30A9 and RAD54L2/ARIP4. Interacts with MACROD1 (By similarity). Interacts (via ligand-binding domain) with TRIM68 (By similarity). Interacts with TNK2 (By similarity). Interacts with USP26 (By similarity). Interacts with RNF6 (By similarity). Interacts (regulated by RNF6 probably through polyubiquitination) with RNF14; regulates AR transcriptional activity. Interacts with PRMT2 and TRIM24. Interacts with GNB2L1/RACK1 (By similarity). Interacts with RANBP10; this interaction enhances hormone-induced AR transcriptional activity (By similarity). Interacts with PRPF6 in a hormone-independent way; this interaction enhances hormone-induced AR transcriptional activity. Interacts with STK4/MST1.

Function:

Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins. Transcription activation is down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3.

Subcellular Location:

Nucleus Cytoplasm Predominantly cytoplasmic in unliganded form but translocates to the nucleus upon ligand-binding. Can also translocate to the nucleus in unliganded form in the presence of GNB2L1.

Protein Attributes:

Sequence length:

899

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

899:

RELHQFTFDL | LIKSHMVSVD | FPEMMAEIIS | VQVPKILSGK | VKPIYFHTQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.39005

KEGG:

mmu:11835

SMR:

P19091

Pfam:

PF02166

String:

P19091

Uniprot:

P19091

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ELISA Kit for Mouse Androgen receptor

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E1252h

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ELISA Kit for Mouse Androgen receptor

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E1252p

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ELISA Kit for Mouse Androgen receptor

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ELISA Kit for Mouse Androgen receptor

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E1252d

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96T

ELISA Kit for Mouse Androgen receptor

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E1252m

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ELISA Kit for Mouse Androgen receptor

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E1252r

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96T

CLIA Kit for Mouse Androgen receptor

Cat.:

U1252d

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96T

CLIA Kit for Mouse Androgen receptor

Cat.:

U1252p

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96T

CLIA Kit for Mouse Androgen receptor

Cat.:

U1252m

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96T

CLIA Kit for Mouse Androgen receptor

Cat.:

U1252r

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96T

CLIA Kit for Mouse Androgen receptor

Cat.:

U1252h

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CLIA Kit for Mouse Androgen receptor

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Polyclonal Antibody for Mouse Androgen receptor

Cat.:

P1252Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse Androgen receptor

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P1252Rb-m

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Polyclonal Antibody for Mouse Androgen receptor

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P1252Rb-h

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Polyclonal Antibody for Mouse Androgen receptor

Monoclonal Antibody for Mouse Androgen receptor

Protein for Mouse Androgen receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning of androgen receptors from divergent species with a polymerase chain reaction technique: complete cDNA sequence of the mouse androgen receptor and isolation of androgen receptor cDNA probes from dog, guinea pig and clawed frog."
He W.W. , Fischer L.M. , Sun S. , Bilhartz D.L. , Zhu X. , Young C.Y.F. , Kelley D.B. , Tindall D.J.
Biochem. Biophys. Res. Commun.171:697-704(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: BALB/c.
2.

"Structure and size distribution of the androgen receptor mRNA in wild-type and Tfm/Y mutant mice."
Gaspar M.L. , Meo T. , Tosi M.
Mol. Endocrinol.4:1600-1610(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The mouse androgen receptor. Functional analysis of the protein and characterization of the gene."
Faber P.W. , King A. , van Rooij H.C.J. , Brinkmann A.O. , de Both N.J. , Trapman J.
Biochem. J.278:269-278(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
4.

"A frameshift mutation destabilizes androgen receptor messenger RNA in the Tfm mouse."
Charest N.J. , Zhou Z. , Lubahn D.B. , Olsen K.L. , Wilson E.M. , French F.S.
Mol. Endocrinol.5:573-581(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Novel ATPase of SNF2-like protein family interacts with androgen receptor and modulates androgen-dependent transcription."
Rouleau N. , Domans'kyi A. , Reeben M. , Moilanen A.-M. , Havas K. , Kang Z. , Owen-Hughes T. , Palvimo J.J. , Jaenne O.A.
Mol. Biol. Cell13:2106-2119(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD54L2
strain: Swiss Webster.
tissue: Embryo.
6.

"Dyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4."
Sitz J.H. , Tigges M. , Baumgaertel K. , Khaspekov L.G. , Lutz B.
Mol. Cell. Biol.24:5821-5834(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RAD54L2
7.

"A zinc finger protein TZF is a novel corepressor of androgen receptor."
Ishizuka M. , Kawate H. , Takayanagi R. , Ohshima H. , Tao R.-H. , Hagiwara H.
Biochem. Biophys. Res. Commun.331:1025-1031(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF318
8.

"GAC63, a GRIP1-dependent nuclear receptor coactivator."
Chen Y.-H. , Kim J.H. , Stallcup M.R.
Mol. Cell. Biol.25:5965-5972(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SLC30A9
9.

"Cryptochromes mediate rhythmic repression of the glucocorticoid receptor."
Lamia K.A. , Papp S.J. , Yu R.T. , Barish G.D. , Uhlenhaut N.H. , Jonker J.W. , Downes M. , Evans R.M.
Nature480:552-556(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CRY1
10.

"A surface on the androgen receptor that allosterically regulates coactivator binding."
Estebanez-Perpina E. , Arnold L.A. , Nguyen P. , Rodrigues E.D. , Mar E. , Bateman R. , Pallai P. , Shokat K.M. , Baxter J.D. , Guy R.K. , Webb P. , Fletterick R.J.
Proc. Natl. Acad. Sci. U.S.A.104:16074-16079(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 649-899 IN COMPLEX WITH NCOA2 AND DIHYDROTESTOSTERONE

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