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Index > Protein center > ANGPTL4(Gene name) > Human
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  • ANGPTL4 (Gene name),
  • Angiopoietin-related protein 4 (Protein name ),  ANGL4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ANGPTL4(PP1158;PSEC0166;UNQ171/PRO197;ARP4;HFARP;PGAR);
    Protein name:
    Angiopoietin-related protein 4;
    Alternative:
    Hepatic fibrinogen/angiopoietin-related protein(HFARP);Angiopoietin-like protein 4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix.
    Function:
    Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
    Subcellular Location:
    Secreted Secreted extracellular space extracellular matrix The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
    Protein Attributes:
    Sequence length:
    406
    Sequence:
    50:
    MSGAPTAGAA | LMLCAATAVL | LSAQGGPVQS | KSPRFASWDE | MNVLAHGLLQ | 
    100:
    LGQGLREHAE | RTRSQLSALE | RRLSACGSAC | QGTEGSTDLP | LAPESRVDPE | 
    150:
    VLHSLQTQLK | AQNSRIQQLF | HKVAQQQRHL | EKQHLRIQHL | QSQFGLLDHK | 
    200:
    HLDHEVAKPA | RRKRLPEMAQ | PVDPAHNVSR | LHRLPRDCQE | LFQVGERQSG | 
    250:
    LFEIQPQGSP | PFLVNCKMTS | DGGWTVIQRR | HDGSVDFNRP | WEAYKAGFGD | 
    300:
    PHGEFWLGLE | KVHSITGDRN | SRLAVQLRDW | DGNAELLQFS | VHLGGEDTAY | 
    350:
    SLQLTAPVAG | QLGATTVPPS | GLSVPFSTWD | QDHDLRRDKN | CAKSLSGGWW | 
    400:
    FGTCSHSNLN | GQYFRSIPQQ | RQKLKKGIFW | KTWRGRYYPL | QATTMLIQPM | 
    406:
    AAEAAS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    KEGG:
    UniGene:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Angiopoietin-related protein 4
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    ELISA Kit for Human Angiopoietin-related protein 4
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    ELISA Kit for Human Angiopoietin-related protein 4
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    CLIA Kit for Human Angiopoietin-related protein 4
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    CLIA Kit for Human Angiopoietin-related protein 4
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    CLIA Kit for Human Angiopoietin-related protein 4
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    Packing:
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    Polyclonal Antibody for Human Angiopoietin-related protein 4
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    P2085Rb-r
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    40ug/0.2ml
    Polyclonal Antibody for Human Angiopoietin-related protein 4
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    Packing:
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    Polyclonal Antibody for Human Angiopoietin-related protein 4
    Polyclonal Antibody for Human Angiopoietin-related protein 4
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    Packing:
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    Polyclonal Antibody for Human Angiopoietin-related protein 4
    Monoclonal Antibody for Human Angiopoietin-related protein 4
    Monoclonal Antibody for Human Angiopoietin-related protein 4
    Monoclonal Antibody for Human Angiopoietin-related protein 4
    Monoclonal Antibody for Human Angiopoietin-related protein 4
    Monoclonal Antibody for Human Angiopoietin-related protein 4
    Protein for Human Angiopoietin-related protein 4
    Protein for Human Angiopoietin-related protein 4
    Protein for Human Angiopoietin-related protein 4
    Cat.:
    R2085h
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    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Angiopoietin-related protein 4
    Protein for Human Angiopoietin-related protein 4

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    References
    1. 1.
      "Hepatic expression, synthesis and secretion of a novel fibrinogen/angiopoietin-related protein that prevents endothelial-cell apoptosis."
      Kim I. , Kim H.-G. , Kim H. , Kim H.-H. , Park S.K. , Uhm C.-S. , Lee Z.H. , Koh G.Y.
      Biochem. J.346:603-610(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;GLYCOSYLATION;VARIANT MET-266
    2. 2.
      "Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation."
      Yoon J.C. , Chickering T.W. , Rosen E.D. , Dussault B. , Qin Y. , Soukas A. , Friedman J.M. , Holmes W.E. , Spiegelman B.M.
      Mol. Cell. Biol.20:5343-5349(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);POSSIBLE FUNCTION
      tissue: Aortic endothelium.
    3. 3.
      "Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis."
      Zhu H. , Li J. , Qin W. , Yang Y. , He X. , Wan D. , Gu J.
      Zhonghua Yi Xue Za Zhi82:94-99(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Placenta.
    4. 4.
      "Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4."
      Ito Y. , Oike Y. , Yasunaga K. , Hamada K. , Miyata K. , Matsumoto S. , Sugano S. , Tanihara H. , Masuho Y. , Suda T.
      Cancer Res.63:6651-6657(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION
      tissue: Placenta.
    5. 5.
      "A catalogue of genes in the human dermal papilla cells as identified by expressed sequence tags."
      Kim M.K. , Kim Y.H. , Seo J.M. , Lee H.M. , Chung H.J. , Sohn M.Y. , Hwang S.Y. , Im S.U. , Jung E.J. , Lee J.H. , Kim J.C.
      Submitted (1999-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Hair follicle dermal papilla.
    6. 6.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Thymus.
    8. 8.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT MET-266
      tissue: Adipose tissue.
    9. 9.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    11. 11.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Pancreas.
    12. 12.
      "Expression and function of hepatocellular carcinoma-related gene pp1158."
      Zhu H. , Li J. , Wan D. , Yang Y. , Qin W. , Ge C. , Yao M. , Gu J.
      Zhonghua Zhong Liu Za Zhi24:123-125(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY
    13. 13.
      "Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL."
      Romeo S. , Pennacchio L.A. , Fu Y. , Boerwinkle E. , Tybjaerg-Hansen A. , Hobbs H.H. , Cohen J.C.
      Nat. Genet.39:513-516(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH TGQTL;VARIANTS LEU-5; LYS-40; ILE-41; ARG-67; LEU-72; ARG-77; LYS-167; SER-174; GLN-190; LYS-196; CYS-230; ARG-233; VAL-237; THR-251; MET-266; GLN-278; MET-291; MET-293; VAL-296; SER-307; MET-308; CYS-336; GLU-338; CYS-349; SER-361; ARG-361; GLN-371 AND TRP-384
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