Gene name:
ANGPTL4 (PP1158;PSEC0166;UNQ171/PRO197;ARP4;HFARP;PGAR) ;
Protein name:
Angiopoietin-related protein 4 ;
Alternative:
Hepatic fibrinogen/angiopoietin-related protein (HFARP) ;Angiopoietin-like protein 4 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homooligomer. The homooligomer undergoes proteolytic processing to release its carboxyl fibrinogen-like domain, which circulates as a monomer. The homooligomer unprocessed form is able to interact with the extracellular matrix.
Function:
Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorgenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation.
Subcellular Location:
Secreted
Secreted
extracellular space
extracellular matrix
The unprocessed form interacts with the extracellular matrix. This may constitute a dynamic reservoir, a regulatory mechanism of the bioavailability of ANGPTL4.
Protein Attributes:
50:
MSGAPTAGAA | LMLCAATAVL | LSAQGGPVQS | KSPRFASWDE | MNVLAHGLLQ |
100:
LGQGLREHAE | RTRSQLSALE | RRLSACGSAC | QGTEGSTDLP | LAPESRVDPE |
150:
VLHSLQTQLK | AQNSRIQQLF | HKVAQQQRHL | EKQHLRIQHL | QSQFGLLDHK |
200:
HLDHEVAKPA | RRKRLPEMAQ | PVDPAHNVSR | LHRLPRDCQE | LFQVGERQSG |
250:
LFEIQPQGSP | PFLVNCKMTS | DGGWTVIQRR | HDGSVDFNRP | WEAYKAGFGD |
300:
PHGEFWLGLE | KVHSITGDRN | SRLAVQLRDW | DGNAELLQFS | VHLGGEDTAY |
350:
SLQLTAPVAG | QLGATTVPPS | GLSVPFSTWD | QDHDLRRDKN | CAKSLSGGWW |
400:
FGTCSHSNLN | GQYFRSIPQQ | RQKLKKGIFW | KTWRGRYYPL | QATTMLIQPM |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
Pig
ELISA Kit for Human Angiopoietin-related protein 4
ELISA Kit for Human Angiopoietin-related protein 4
ELISA Kit for Human Angiopoietin-related protein 4
ELISA Kit for Human Angiopoietin-related protein 4
ELISA Kit for Human Angiopoietin-related protein 4
CLIA Kit for Human Angiopoietin-related protein 4
CLIA Kit for Human Angiopoietin-related protein 4
CLIA Kit for Human Angiopoietin-related protein 4
CLIA Kit for Human Angiopoietin-related protein 4
CLIA Kit for Human Angiopoietin-related protein 4
Polyclonal Antibody for Human Angiopoietin-related protein 4
Polyclonal Antibody for Human Angiopoietin-related protein 4
Polyclonal Antibody for Human Angiopoietin-related protein 4
Polyclonal Antibody for Human Angiopoietin-related protein 4
Polyclonal Antibody for Human Angiopoietin-related protein 4
Monoclonal Antibody for Human Angiopoietin-related protein 4
Monoclonal Antibody for Human Angiopoietin-related protein 4
Monoclonal Antibody for Human Angiopoietin-related protein 4
Monoclonal Antibody for Human Angiopoietin-related protein 4
Monoclonal Antibody for Human Angiopoietin-related protein 4
Protein for Human Angiopoietin-related protein 4
Protein for Human Angiopoietin-related protein 4
Protein for Human Angiopoietin-related protein 4
Protein for Human Angiopoietin-related protein 4
Protein for Human Angiopoietin-related protein 4
R&D Technical Data
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Precision
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Recovery
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Linearity
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Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
11.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Pancreas .
12.
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Cited for : FUNCTION;TISSUE SPECIFICITY
13.
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Cited for : ASSOCIATION WITH TGQTL;VARIANTS LEU-5; LYS-40; ILE-41; ARG-67; LEU-72; ARG-77; LYS-167; SER-174; GLN-190; LYS-196; CYS-230; ARG-233; VAL-237; THR-251; MET-266; GLN-278; MET-291; MET-293; VAL-296; SER-307; MET-308; CYS-336; GLU-338; CYS-349; SER-361; ARG-361; GLN-371 AND TRP-384