Gene name:
ANGPT1 (KIAA0003) ;
Protein name:
Angiopoietin-1 (ANG-1) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Function:
Binds and activates TIE2 receptor by inducing its tyrosine phosphorylation. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. Mediates blood vessel maturation/stability. It may play an important role in the heart early development.
Subcellular Location:
Secreted
Protein Attributes:
50:
MTVFLSFAFL | AAILTHIGCS | NQRRSPENSG | RRYNRIQHGQ | CAYTFILPEH |
100:
DGNCRESTTD | QYNTNALQRD | APHVEPDFSS | QKLQHLEHVM | ENYTQWLQKL |
150:
ENYIVENMKS | EMAQIQQNAV | QNHTATMLEI | GTSLLSQTAE | QTRKLTDVET |
200:
QVLNQTSRLE | IQLLENSLST | YKLEKQLLQQ | TNEILKIHEK | NSLLEHKILE |
250:
MEGKHKEELD | TLKEEKENLQ | GLVTRQTYII | QELEKQLNRA | TTNNSVLQKQ |
300:
QLELMDTVHN | LVNLCTKEGV | LLKGGKREEE | KPFRDCADVY | QAGFNKSGIY |
350:
TIYINNMPEP | KKVFCNMDVN | GGGWTVIQHR | EDGSLDFQRG | WKEYKMGFGN |
400:
PSGEYWLGNE | FIFAITSQRQ | YMLRIELMDW | EGNRAYSQYD | RFHIGNEKQN |
450:
YRLYLKGHTG | TAGKQSSLIL | HGADFSTKDA | DNDNCMCKCA | LMLTGGWWFD |
498:
ACGPSNLNGM | FYTAGQNHGK | LNGIKWHYFK | GPSYSLRSTT | MMIRPLDF
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Pig
Bovine
Dog
ELISA Kit for Human ANG-1
ELISA Kit for Human ANG-1
ELISA Kit for Human ANG-1
ELISA Kit for Human ANG-1
ELISA Kit for Human ANG-1
ELISA Kit for Human ANG-1
Polyclonal Antibody for Human ANG-1
Polyclonal Antibody for Human ANG-1
Polyclonal Antibody for Human ANG-1
Polyclonal Antibody for Human ANG-1
Polyclonal Antibody for Human ANG-1
Polyclonal Antibody for Human ANG-1
Monoclonal Antibody for Human ANG-1
Monoclonal Antibody for Human ANG-1
Monoclonal Antibody for Human ANG-1
Monoclonal Antibody for Human ANG-1
Monoclonal Antibody for Human ANG-1
Monoclonal Antibody for Human ANG-1
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
Yesildal F, Koc E, Tas A, et al.
References
1.
"Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning."
Davis S.
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Aldrich T.H.
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Jones P.F.
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Acheson A.
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Compton D.L.
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Cell87:1161-1169(1996)
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PubMed ]
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Europe PMC ]
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Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Fetal lung .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Bone marrow .
5.
"The full-ORF clone resource of the German cDNA consortium."
Bechtel S.
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Rosenfelder H.
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Duda A.
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BMC Genomics8:399-399(2007)
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Europe PMC ]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue :
Small intestine .
6.
"DNA sequence and analysis of human chromosome 8."
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more...
Nature439:331-335(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
8.
Mural R.J.
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Istrail S.
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Sutton G.
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more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SEQUENCE REVISION
10.
"Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis."
Maisonpierre P.C.
,
Suri C.
,
Jones P.F.
,
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,
Wiegand S.J.
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Science277:55-60(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH TEK
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TEK
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN REGULATION OF ANGIOGENESIS; CELL SURVIVAL; CELL MIGRATION AND ACTIVATION OF AKT1;INTERACTION WITH TEK/TIE2
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN REGULATION OF ENDOTHELIAL CELL MIGRATION AND CELL SPREADING
14.
"Angiopoietins assemble distinct Tie2 signalling complexes in endothelial cell-cell and cell-matrix contacts."
Saharinen P.
,
Eklund L.
,
Miettinen J.
,
Wirkkala R.
,
Anisimov A.
,
Winderlich M.
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Deutsch U.
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Koh G.Y.
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Olsen B.R.
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Alitalo K.
Nat. Cell Biol.10:527-537(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN REGULATION OF ENDOTHELIAL CELL MIGRATION
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW