ANK2 ELISA Kit for Human(Homo sapiens) | EIAab.comANK2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ANK2(Gene name) > Human

ANK2 (Gene name),

Ankyrin-2 (Protein name ), ANK2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ANK2;

Protein name:

Ankyrin-2(ANK-2);

Alternative:

Brain ankyrin;Ankyrin-B;Non-erythroid ankyrin;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with RHBG and SPTBN1.

Function:

Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes. Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.

Subcellular Location:

Cytoplasm cytoskeleton Membrane Cytoplasm myofibril sarcomere M line Apical cell membrane Cell membrane Expressed at the apical membrane of airway lung epithelial cells (By similarity). Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distict intracellular compartment of neonatal cardiomyocytes.

Protein Attributes:

Sequence length:

3924

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DGYSKVIKRV | VLKSDTEQSE | DNNE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

106410

Pfam:

PF00023

String:

Q01484

KEGG:

hsa:287

SMR:

Q01484

UniGene:

Hs.620557

STRING:

9606.ENSP00000349588

Uniprot:

Q01484

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ELISA Kit for Human ANK-2

Cat.:

E1633h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Human ANK-2

Cat.:

E1633m

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MSDS:

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Packing:

96T

CLIA Kit for Human ANK-2

Cat.:

U1633m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human ANK-2

Cat.:

U1633h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human ANK-2

Cat.:

P1633Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human ANK-2

Cat.:

P1633Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human ANK-2

Protein for Human ANK-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Isolation and characterization of cDNAs encoding human brain ankyrins reveal a family of alternatively spliced genes."
Otto E. , Kunimoto M. , McLaughlin T. , Bennett V.
J. Cell Biol.114:241-253(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [MRNA] OF 1477-2110 (ISOFORM 3);TISSUE SPECIFICITY
tissue: Brain stem.
2.

Carpenter S.
Submitted (1999-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
3.

"440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons."
Chan W. , Kordeli E. , Bennett V.
J. Cell Biol.123:1463-1473(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Brain stem.
4.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
tissue: Retina.
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
7.

"Isolation and chromosomal localization of a novel nonerythroid ankyrin gene."
Tse W.T. , Menninger J.C. , Yang-Feng T.L. , Francke U. , Sahr K.E. , Lux S.E. , Ward D.C. , Forget B.G.
Genomics10:858-866(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 463-495;TISSUE SPECIFICITY
8.

"Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death."
Mohler P.J. , Schott J.-J. , Gramolini A.O. , Dilly K.W. , Guatimosim S. , duBell W.H. , Song L.-S. , Haurogne K. , Kyndt F. , Ali M.E. , Rogers T.B. , Lederer W.J. , Escande D. , Le Marec H. , Bennett V.
Nature421:634-639(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANT LQT4 GLY-1458
9.

"Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes."
Mohler P.J. , Yoon W. , Bennett V.
J. Biol. Chem.279:40185-40193(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPTBN1;MUTAGENESIS OF 975-ASP--ARG-977; ALA-1000 AND 1100-GLU--ASP-1103
10.

"The ammonium transporter RhBG: requirement of a tyrosine-based signal and ankyrin-G for basolateral targeting and membrane anchorage in polarized kidney epithelial cells."
Lopez C. , Metral S. , Eladari D. , Drevensek S. , Gane P. , Chambrey R. , Bennett V. , Cartron J.-P. , Le Van Kim C. , Colin Y.
J. Biol. Chem.280:8221-8228(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RHBG
11.

"Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors."
Kizhatil K. , Sandhu N.K. , Peachey N.S. , Bennett V.
Exp. Eye Res.88:57-64(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
14.

"Structure of the ZU5-ZU5-UPA-DD tandem of ankyrin-B reveals interaction surfaces necessary for ankyrin function."
Wang C. , Yu C. , Ye F. , Wei Z. , Zhang M.
Proc. Natl. Acad. Sci. U.S.A.109:4822-4827(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 966-3620;DOMAIN DEATH 1;DOMAIN UPA;DOMAINS ZU5
15.

"A cardiac arrhythmia syndrome caused by loss of ankyrin-B function."
Mohler P.J. , Splawski I. , Napolitano C. , Bottelli G. , Sharpe L. , Timothy K. , Priori S.G. , Keating M.T. , Bennett V.
Proc. Natl. Acad. Sci. U.S.A.101:9137-9142(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LQT4 GLY-1458; ILE-3740; ASN-3744; TRP-3906 AND LYS-3931;CHARACTERIZATION OF VARIANTS LQT4
16.

"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T. , Jones S. , Wood L.D. , Parsons D.W. , Lin J. , Barber T.D. , Mandelker D. , Leary R.J. , Ptak J. , Silliman N. , Szabo S. , Buckhaults P. , Farrell C. , Meeh P. , Markowitz S.D. , Willis J. , Dawson D. , Willson J.K.V. , more...
Science314:268-274(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] GLU-685; ARG-1267 AND LYS-3653

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