Ank2 ELISA Kit for Mouse(Mus musculus) | EIAab.comAnk2 ELISA Kit for Mouse(Mus musculus)

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Ank2 (Gene name),

Ankyrin-2 (Protein name ), ANK2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Ank2;

Protein name:

Ankyrin-2(ANK-2);

Alternative:

Brain ankyrin;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with RHBG and SPTBN1 (By similarity). Colocalizes with Na/K ATPase, Na/Ca exchanger and SPTBN1.

Function:

Attaches integral membrane proteins to cytoskeletal elements. Also binds to cytoskeletal proteins. Required for coordinate assembly of Na/Ca exchanger, Na/K ATPase and InsP3 receptor at sarcoplasmic reticulum sites in cardiomyocytes (By similarity). Required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) in the inner segment of rod photoreceptors. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate.

Subcellular Location:

Cytoplasm cytoskeleton Membrane Cytoplasm myofibril sarcomere M line Apical cell membrane Cell membrane Expressed at the apical membrane of airway lung epithelial cells. Localized to the plasma membrane of the inner segments of photoreceptors in retina. Colocalizes with SPTBN1 in a distict intracellular compartment of neonatal cardiomyocytes.

Protein Attributes:

Sequence length:

3898

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SDGTEKEEVT | MQGMPQEPVN | IEDGDNYSKV | IKRVVLKSDT | QQSEDNNE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q8C8R3

UniGene:

Mm.220242

SMR:

Q8C8R3

Pfam:

PF00023

KEGG:

mmu:109676

Uniprot:

Q8C8R3

FOR

ELISA Kit for Mouse ANK-2

Cat.:

E1633h

Price:

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Manual:

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MSDS:

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Packing:

96T

Range:

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ELISA Kit for Mouse ANK-2

Cat.:

E1633m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse ANK-2

Cat.:

U1633m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Mouse ANK-2

Cat.:

U1633h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse ANK-2

Cat.:

P1633Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse ANK-2

Cat.:

P1633Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse ANK-2

Protein for Mouse ANK-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 6; 7 AND 8);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1674 (ISOFORM 5);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1190 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3402-3897 (ISOFORM 4)
strain: C57BL/6J.
tissue: Cerebellum.
tissue: Hippocampus.
tissue: Lung.
tissue: Medulla oblongata.
tissue: Retina.
tissue: Spinal ganglion.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2922-3898 (ISOFORM 4)
strain: C57BL/6.
tissue: Brain.
4.

"440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons."
Chan W. , Kordeli E. , Bennett V.
J. Cell Biol.123:1463-1473(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
5.

"Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes."
Mohler P.J. , Yoon W. , Bennett V.
J. Biol. Chem.279:40185-40193(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;DEVELOPMENTAL STAGE
6.

"Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
Trinidad J.C. , Specht C.G. , Thalhammer A. , Schoepfer R. , Burlingame A.L.
Mol. Cell. Proteomics5:914-922(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-30 (ISOFORM 2);IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
7.

"Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence."
Mohler P.J. , Healy J.A. , Xue H. , Puca A.A. , Kline C.F. , Allingham R.R. , Kranias E.G. , Rockman H.A. , Bennett V.
PLoS ONE2:E1051-E1051(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
8.

"An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan."
Ayalon G. , Davis J.Q. , Scotland P.B. , Bennett V.
Cell135:1189-1200(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH DMD AND DCTN4;SUBCELLULAR LOCATION
9.

"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A. , Carey G.R. , Sunyaev S.R. , Gygi S.P.
J. Proteome Res.7:311-318(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-378; TYR-531 AND TYR-1349;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Brain.
10.

"Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors."
Kizhatil K. , Sandhu N.K. , Peachey N.S. , Bennett V.
Exp. Eye Res.88:57-64(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;TISSUE SPECIFICITY

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