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Index > Protein center > NPR2(Gene name) > Human
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  • NPR2 (Gene name),
  • Atrial natriuretic peptide receptor 2 (Protein name ),  ANPRB_HUMAN from NCBI database.
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  • General Annotation
  • |
  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    NPR2(ANPRB);
    Protein name:
    Atrial natriuretic peptide receptor 2;
    Alternative:
    Guanylate cyclase B(GC-B);Atrial natriuretic peptide receptor type B(ANP-B;ANPR-B;NPR-B);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1047
    Sequence:
    50:
    MALPSLLLLV | AALAGGVRPP | GARNLTLAVV | LPEHNLSYAW | AWPRVGPAVA | 
    100:
    LAVEALGRAL | PVDLRFVSSE | LEGACSEYLA | PLSAVDLKLY | HDPDLLLGPG | 
    150:
    CVYPAASVAR | FASHWRLPLL | TAGAVASGFS | AKNDHYRTLV | RTGPSAPKLG | 
    200:
    EFVVTLHGHF | NWTARAALLY | LDARTDDRPH | YFTIEGVFEA | LQGSNLSVQH | 
    250:
    QVYAREPGGP | EQATHFIRAN | GRIVYICGPL | EMLHEILLQA | QRENLTNGDY | 
    300:
    VFFYLDVFGE | SLRAGPTRAT | GRPWQDNRTR | EQAQALREAF | QTVLVITYRE | 
    350:
    PPNPEYQEFQ | NRLLIRARED | FGVELGPSLM | NLIAGCFYDG | ILLYAEVLNE | 
    400:
    TIQEGGTRED | GLRIVEKMQG | RRYHGVTGLV | VMDKNNDRET | DFVLWAMGDL | 
    450:
    DSGDFQPAAH | YSGAEKQIWW | TGRPIPWVKG | APPSDNPPCA | FDLDDPSCDK | 
    500:
    TPLSTLAIVA | LGTGITFIMF | GVSSFLIFRK | LMLEKELASM | LWRIRWEELQ | 
    550:
    FGNSERYHKG | AGSRLTLSLR | GSSYGSLMTA | HGKYQIFANT | GHFKGNVVAI | 
    600:
    KHVNKKRIEL | TRQVLFELKH | MRDVQFNHLT | RFIGACIDPP | NICIVTEYCP | 
    650:
    RGSLQDILEN | DSINLDWMFR | YSLINDLVKG | MAFLHNSIIS | SHGSLKSSNC | 
    700:
    VVDSRFVLKI | TDYGLASFRS | TAEPDDSHAL | YAKKLWTAPE | LLSGNPLPTT | 
    750:
    GMQKADVYSF | GIILQEIALR | SGPFYLEGLD | LSPKEIVQKV | RNGQRPYFRP | 
    800:
    SIDRTQLNEE | LVLLMERCWA | QDPAERPDFG | QIKGFIRRFN | KEGGTSILDN | 
    850:
    LLLRMEQYAN | NLEKLVEERT | QAYLEEKRKA | EALLYQILPH | SVAEQLKRGE | 
    900:
    TVQAEAFDSV | TIYFSDIVGF | TALSAESTPM | QVVTLLNDLY | TCFDAIIDNF | 
    950:
    DVYKVETIGD | AYMVVSGLPG | RNGQRHAPEI | ARMALALLDA | VSSFRIRHRP | 
    1000:
    HDQLRLRIGV | HTGPVCAGVV | GLKMPRYCLF | GDTVNTASRM | ESNGQALKIH | 
    1047:
    VSSTTKDALD | ELGCFQLELR | GDVEMKGKGK | MRTYWLLGER | KGPPGLL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    SMR:
    String:
    KEGG:
    MIM:
    Uniprot:
     
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    CLIA Kit for Human Atrial natriuretic peptide receptor 2
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    Polyclonal Antibody for Human Atrial natriuretic peptide receptor 2
    Polyclonal Antibody for Human Atrial natriuretic peptide receptor 2
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    Polyclonal Antibody for Human Atrial natriuretic peptide receptor 2
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    Polyclonal Antibody for Human Atrial natriuretic peptide receptor 2
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    Packing:
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    Monoclonal Antibody for Human Atrial natriuretic peptide receptor 2
    Monoclonal Antibody for Human Atrial natriuretic peptide receptor 2
    Monoclonal Antibody for Human Atrial natriuretic peptide receptor 2
    Monoclonal Antibody for Human Atrial natriuretic peptide receptor 2
    Protein for Human Atrial natriuretic peptide receptor 2
    Protein for Human Atrial natriuretic peptide receptor 2
    Protein for Human Atrial natriuretic peptide receptor 2
    Protein for Human Atrial natriuretic peptide receptor 2

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    References
    1. 1.
      "Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases."
      Chang M.S. , Lowe D.G. , Lewis M. , Hellmiss R. , Chen E. , Goeddel D.V.
      Nature341:68-72(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM LONG)
      tissue: Brain.
    2. 2.
      "Structure of the type B human natriuretic peptide receptor gene and association of a novel microsatellite polymorphism with essential hypertension."
      Rehemudula D. , Nakayama T. , Soma M. , Takahashi Y. , Uwabo J. , Sato M. , Izumi Y. , Kanmatsuse K. , Ozawa Y.
      Circ. Res.84:605-610(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Blood.
    3. 3.
      "cGMP-dependent and -independent inhibition of a K+ conductance by natriuretic peptides: molecular and functional studies in human proximal tubule cells."
      Hirsch J.R. , Meyer M. , Maegert H.-J. , Forssmann W.-G. , Mollerup S. , Herter P. , Weber G. , Cermak R. , Ankorina-Stark I. , Schlatter E. , Kruhoffer M.
      J. Am. Soc. Nephrol.10:472-480(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
      tissue: Kidney.
    4. 4.
      "DNA sequence and analysis of human chromosome 9."
      Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
      Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
      tissue: Brain.
    8. 8.
      "Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
      Bennett B.D. , Bennett G.L. , Vitangcol R.V. , Jewett J.R. , Burnier J. , Henzel W. , Lowe D.G.
      J. Biol. Chem.266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND-BINDING
    9. 9.
      "Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
      Koller K.J. , Lowe D.G. , Bennett G.L. , Minamino N. , Kangawa K. , Matsuo H. , Goeddel D.V.
      Science252:120-123(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "An unappreciated role for RNA surveillance."
      Hillman R.T. , Green R.E. , Brenner S.E.
      Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
    11. 11.
      "Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux."
      Bartels C.F. , Buekuelmez H. , Padayatti P. , Rhee D.K. , van Ravenswaaij-Arts C. , Pauli R.M. , Mundlos S. , Chitayat D. , Shih L.-Y. , Al-Gazali L.I. , Kant S. , Cole T. , Morton J. , Cormier-Daire V. , Faivre L. , Lees M. , Kirk J. , Mortier G.R. , more...
      Am. J. Hum. Genet.75:27-34(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANTS AMDM THR-32; GLY-115; GLU-176; MET-297; CYS-338; THR-409; GLU-413; CYS-708; TRP-776; CYS-957 AND ALA-959;CHARACTERIZATION OF VARIANTS AMDM GLY-115; MET-297 AND GLU-413
    12. 12.
      "Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B."
      Yoder A.R. , Stone M.D. , Griffin T.J. , Potter L.R.
      Biochemistry49:10137-10145(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-513; THR-516; SER-518; SER-523; SER-526 AND THR-529
    13. 14.
      "An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene."
      Miura K. , Namba N. , Fujiwara M. , Ohata Y. , Ishida H. , Kitaoka T. , Kubota T. , Hirai H. , Higuchi C. , Tsumaki N. , Yoshikawa H. , Sakai N. , Michigami T. , Ozono K.
      PLoS ONE7:E42180-E42180(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ECDM;VARIANT ECDM MET-882;CHARACTERIZATION OF VARIANT ECDM MET-882
    14. 15.
      "A human skeletal overgrowth mutation increases maximal velocity and blocks desensitization of guanylyl cyclase-B."
      Robinson J.W. , Dickey D.M. , Miura K. , Michigami T. , Ozono K. , Potter L.R.
      Bone56:375-382(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT ECDM MET-882
    15. 16.
      "An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities."
      Hannema S.E. , van Duyvenvoorde H.A. , Premsler T. , Yang R.B. , Mueller T.D. , Gassner B. , Oberwinkler H. , Roelfsema F. , Santen G.W. , Prickett T. , Kant S.G. , Verkerk A.J. , Uitterlinden A.G. , Espiner E. , Ruivenkamp C.A. , Oostdijk W. , Pereira A.M. , Losekoot M. , more...
      J. Clin. Endocrinol. Metab.98:E1988-E1998(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ECDM CYS-655;CHARACTERIZATION OF VARIANT ECDM CYS-655
    16. 17.
      "Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene."
      Miura K. , Kim O.H. , Lee H.R. , Namba N. , Michigami T. , Yoo W.J. , Choi I.H. , Ozono K. , Cho T.J.
      Am. J. Med. Genet. A164A:156-163(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ECDM PRO-488;CHARACTERIZATION OF VARIANT ECDM PRO-488
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