NPR2 ELISA Kit for Human(Homo sapiens) | EIAab.comNPR2 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > NPR2(Gene name) > Human

NPR2 (Gene name),

Atrial natriuretic peptide receptor 2 (Protein name ), ANPRB_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NPR2(ANPRB);

Protein name:

Atrial natriuretic peptide receptor 2;

Alternative:

Guanylate cyclase B(GC-B);Atrial natriuretic peptide receptor type B(ANP-B;ANPR-B;NPR-B);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Receptor for the C-type natriuretic peptide NPPC/CNP hormone. Has guanylate cyclase activity upon binding of its ligand. May play a role in the regulation of skeletal growth.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

1047

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

950:

1000:

1047:

VSSTTKDALD | ELGCFQLELR | GDVEMKGKGK | MRTYWLLGER | KGPPGLL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01094

UniGene:

Hs.78518

SMR:

P20594

STRING:

9606.ENSP00000341083

String:

P20594

KEGG:

hsa:4882

MIM:

108961

Uniprot:

P20594

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ELISA Kit for Human Atrial natriuretic peptide receptor 2

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E1130h

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96T

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ELISA Kit for Human Atrial natriuretic peptide receptor 2

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E1130r

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96T

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ELISA Kit for Human Atrial natriuretic peptide receptor 2

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E1130b

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96T

ELISA Kit for Human Atrial natriuretic peptide receptor 2

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E1130m

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96T

CLIA Kit for Human Atrial natriuretic peptide receptor 2

Cat.:

U1130h

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96T

CLIA Kit for Human Atrial natriuretic peptide receptor 2

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U1130b

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96T

CLIA Kit for Human Atrial natriuretic peptide receptor 2

Cat.:

U1130m

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96T

CLIA Kit for Human Atrial natriuretic peptide receptor 2

Cat.:

U1130r

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96T

Polyclonal Antibody for Human Atrial natriuretic peptide receptor 2

Cat.:

P1130Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Atrial natriuretic peptide receptor 2

Cat.:

P1130Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Atrial natriuretic peptide receptor 2

Cat.:

P1130Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Human Atrial natriuretic peptide receptor 2

Protein for Human Atrial natriuretic peptide receptor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Differential activation by atrial and brain natriuretic peptides of two different receptor guanylate cyclases."
Chang M.S. , Lowe D.G. , Lewis M. , Hellmiss R. , Chen E. , Goeddel D.V.
Nature341:68-72(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM LONG)
tissue: Brain.
2.

"Structure of the type B human natriuretic peptide receptor gene and association of a novel microsatellite polymorphism with essential hypertension."
Rehemudula D. , Nakayama T. , Soma M. , Takahashi Y. , Uwabo J. , Sato M. , Izumi Y. , Kanmatsuse K. , Ozawa Y.
Circ. Res.84:605-610(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
tissue: Blood.
3.

"cGMP-dependent and -independent inhibition of a K+ conductance by natriuretic peptides: molecular and functional studies in human proximal tubule cells."
Hirsch J.R. , Meyer M. , Maegert H.-J. , Forssmann W.-G. , Mollerup S. , Herter P. , Weber G. , Cermak R. , Ankorina-Stark I. , Schlatter E. , Kruhoffer M.
J. Am. Soc. Nephrol.10:472-480(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT)
tissue: Kidney.
4.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

NHLBI resequencing and genotyping service (RS&G)
Submitted (2007-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG)
tissue: Brain.
8.

"Extracellular domain-IgG fusion proteins for three human natriuretic peptide receptors. Hormone pharmacology and application to solid phase screening of synthetic peptide antisera."
Bennett B.D. , Bennett G.L. , Vitangcol R.V. , Jewett J.R. , Burnier J. , Henzel W. , Lowe D.G.
J. Biol. Chem.266:23060-23067(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LIGAND-BINDING
9.

"Selective activation of the B natriuretic peptide receptor by C-type natriuretic peptide (CNP)."
Koller K.J. , Lowe D.G. , Bennett G.L. , Minamino N. , Kangawa K. , Matsuo H. , Goeddel D.V.
Science252:120-123(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"An unappreciated role for RNA surveillance."
Hillman R.T. , Green R.E. , Brenner S.E.
Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
11.

"Mutations in the transmembrane natriuretic peptide receptor NPR-B impair skeletal growth and cause acromesomelic dysplasia, type Maroteaux."
Bartels C.F. , Buekuelmez H. , Padayatti P. , Rhee D.K. , van Ravenswaaij-Arts C. , Pauli R.M. , Mundlos S. , Chitayat D. , Shih L.-Y. , Al-Gazali L.I. , Kant S. , Cole T. , Morton J. , Cormier-Daire V. , Faivre L. , Lees M. , Kirk J. , Mortier G.R. , more...
Am. J. Hum. Genet.75:27-34(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANTS AMDM THR-32; GLY-115; GLU-176; MET-297; CYS-338; THR-409; GLU-413; CYS-708; TRP-776; CYS-957 AND ALA-959;CHARACTERIZATION OF VARIANTS AMDM GLY-115; MET-297 AND GLU-413
12.

"Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B."
Yoder A.R. , Stone M.D. , Griffin T.J. , Potter L.R.
Biochemistry49:10137-10145(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-513; THR-516; SER-518; SER-523; SER-526 AND THR-529
13.

"Patterns of somatic mutation in human cancer genomes."
Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-232 AND ILE-882
14.

"An overgrowth disorder associated with excessive production of cGMP due to a gain-of-function mutation of the natriuretic peptide receptor 2 gene."
Miura K. , Namba N. , Fujiwara M. , Ohata Y. , Ishida H. , Kitaoka T. , Kubota T. , Hirai H. , Higuchi C. , Tsumaki N. , Yoshikawa H. , Sakai N. , Michigami T. , Ozono K.
PLoS ONE7:E42180-E42180(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN ECDM;VARIANT ECDM MET-882;CHARACTERIZATION OF VARIANT ECDM MET-882
15.

"A human skeletal overgrowth mutation increases maximal velocity and blocks desensitization of guanylyl cyclase-B."
Robinson J.W. , Dickey D.M. , Miura K. , Michigami T. , Ozono K. , Potter L.R.
Bone56:375-382(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT ECDM MET-882
16.

"An activating mutation in the kinase homology domain of the natriuretic peptide receptor-2 causes extremely tall stature without skeletal deformities."
Hannema S.E. , van Duyvenvoorde H.A. , Premsler T. , Yang R.B. , Mueller T.D. , Gassner B. , Oberwinkler H. , Roelfsema F. , Santen G.W. , Prickett T. , Kant S.G. , Verkerk A.J. , Uitterlinden A.G. , Espiner E. , Ruivenkamp C.A. , Oostdijk W. , Pereira A.M. , Losekoot M. , more...
J. Clin. Endocrinol. Metab.98:E1988-E1998(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ECDM CYS-655;CHARACTERIZATION OF VARIANT ECDM CYS-655
17.

"Overgrowth syndrome associated with a gain-of-function mutation of the natriuretic peptide receptor 2 (NPR2) gene."
Miura K. , Kim O.H. , Lee H.R. , Namba N. , Michigami T. , Yoo W.J. , Choi I.H. , Ozono K. , Cho T.J.
Am. J. Med. Genet. A164A:156-163(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ECDM PRO-488;CHARACTERIZATION OF VARIANT ECDM PRO-488

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