ANKRD28 ELISA Kit for Human(Homo sapiens) | EIAab.comANKRD28 ELISA Kit for Human(Homo sapiens) | EIAab.com

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ANKRD28 (Gene name),

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A (Protein name ), ANR28_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

ANKRD28(KIAA0379);

Protein name:

Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A(PP6-ARS-A;Serine/threonine-protein phosphatase 6 regulatory subunit ARS-A);

Alternative:

Phosphatase interactor targeting protein hnRNP K(PITK);Ankyrin repeat domain-containing protein 28;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Protein phospatase 6 (PP6) holoenzyme is proposed to be a heterotrimeric complex formed by the catalytic subunit, a SAPS domain-containing subunit (PP6R) and an ankyrin repeat-domain containing regulatory subunit (ARS). Interacts with PPP1C and HNRPK. Interacts with PPP6C, PPP6R1 and PPP6R3.

Function:

Putative regulatory subunit of protein phospatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation.

Subcellular Location:

Nucleus nucleoplasm Seems to be excluded from nucleoli.

Protein Attributes:

Sequence length:

1053

Sequence:

50:

MAFLKLRDQP | SLVQAIFNGD | PDEVRALIFK | KEDVNFQDNE | KRTPLHAAAY |

100:

LGDAEIIELL | ILSGARVNAK | DSKWLTPLHR | AVASCSEEAV | QVLLKHSADV |

150:

NARDKNWQTP | LHIAAANKAV | KCAEALVPLL | SNVNVSDRAG | RTALHHAAFS |

200:

GHGEMVKLLL | SRGANINAFD | KKDRRAIHWA | AYMGHIEVVK | LLVSHGAEVT |

250:

CKDKKSYTPL | HAAASSGMIS | VVKYLLDLGV | DMNEPNAYGN | TPLHVACYNG |

300:

QDVVVNELID | CGAIVNQKNE | KGFTPLHFAA | ASTHGALCLE | LLVGNGADVN |

350:

MKSKDGKTPL | HMTALHGRFS | RSQTIIQSGA | VIDCEDKNGN | TPLHIAARYG |

400:

HELLINTLIT | SGADTAKRGI | HGMFPLHLAA | LSGFSDCCRK | LLSSGFDIDT |

450:

PDDFGRTCLH | AAAAGGNLEC | LNLLLNTGAD | FNKKDKFGRS | PLHYAAANCN |

500:

YQCLFALVGS | GASVNDLDER | GCTPLHYAAT | SDTDGKCLEY | LLRNDANPGI |

550:

RDKQGYNAVH | YSAAYGHRLC | LQLIASETPL | DVLMETSGTD | MLSDSDNRAT |

600:

ISPLHLAAYH | GHHQALEVLV | QSLLDLDVRN | SSGRTPLDLA | AFKGHVECVD |

650:

VLINQGASIL | VKDYILKRTP | IHAAATNGHS | ECLRLLIGNA | EPQNAVDIQD |

700:

GNGQTPLMLS | VLNGHTDCVY | SLLNKGANVD | AKDKWGRTAL | HRGAVTGHEE |

750:

CVDALLQHGA | KCLLRDSRGR | TPIHLSAACG | HIGVLGALLQ | SAASMDANPA |

800:

TADNHGYTAL | HWACYNGHET | CVELLLEQEV | FQKTEGNAFS | PLHCAVINDN |

850:

EGAAEMLIDT | LGASIVNATD | SKGRTPLHAA | AFTDHVECLQ | LLLSHNAQVN |

900:

SVDSTGKTPL | MMAAENGQTN | TVEMLVSSAS | AELTLQDNSK | NTALHLACSK |

950:

GHETSALLIL | EKITDRNLIN | ATNAALQTPL | HVAARNGLTM | VVQELLGKGA |

1000:

SVLAVDENGY | TPALACAPNK | DVADCLALIL | ATMMPVSSSS | PLSSLTFNAI |

1050:

NRYTNTSKTV | SFEALPIMRN | EPSSYCSFNN | IGGEQEYLYT | DVDELNDSDS |

1053:

ETY

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Pfam:

MIM:

STRING:

9606.ENSP00000382379

UniGene:

KEGG:

SMR:

Uniprot:

FOR

ELISA Kit for Human PP6-ARS-A

ELISA Kit for Human PP6-ARS-A

CLIA Kit for Human PP6-ARS-A

CLIA Kit for Human PP6-ARS-A

Polyclonal Antibody for Human PP6-ARS-A

Polyclonal Antibody for Human PP6-ARS-A

Monoclonal Antibody for Human PP6-ARS-A

Monoclonal Antibody for Human PP6-ARS-A

Protein for Human PP6-ARS-A

Protein for Human PP6-ARS-A

R&D Technical Data

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Precision

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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References

1.

"Cloning a new transcript of KIAA0379 protein in testis."
Lu L. , Huang X.Y. , Yin L.L. , Xu M. , Li J.M. , Zhou Z.M. , Sha J.H.
Submitted (2003-08) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Testis.
2.

"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T. , Ishikawa K. , Nakajima D. , Ohira M. , Seki N. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.4:141-150(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Brain.
3.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-767 (ISOFORM 3)
tissue: Amygdala.
tissue: Cerebellum.
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-752 (ISOFORMS 3 AND 4)
6.

"PITK, a PP1 targeting subunit that modulates the phosphorylation of the transcriptional regulator hnRNP K."
Kwiek N.C. , Thacker D.F. , Datto M.B. , Megosh H.B. , Haystead T.A.J.
Cell. Signal.18:1769-1778(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PPP1C AND HNRPK;PHOSPHORYLATION AT SER-1007 AND SER-1011;MUTAGENESIS OF 1007-SER--SER-1011
7.

"Protein phosphatase 6 regulatory subunits composed of ankyrin repeat domains."
Stefansson B. , Ohama T. , Daugherty A.E. , Brautigan D.L.
Biochemistry47:1442-1451(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH PPP6C; PPP6R1 AND PPP6R3
8.

"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"Large-scale proteomics analysis of the human kinome."
Oppermann F.S. , Gnad F. , Olsen J.V. , Hornberger R. , Greff Z. , Keri G. , Mann M. , Daub H.
Mol. Cell. Proteomics8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]

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