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Index > Protein center > MAOA(Gene name) > Human
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  • MAOA (Gene name),
  • Amine oxidase [flavin-containing] A (Protein name ),  AOFA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MAOA;
    Protein name:
    Amine oxidase [flavin-containing] A;
    Alternative:
    Monoamine oxidase type A(MAO-A);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.
    Function:
    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine.
    Subcellular Location:
    Mitochondrion outer membrane Single-pass type IV membrane protein Cytoplasmic side
    Protein Attributes:
    Sequence length:
    527
    Sequence:
    50:
    MENQEKASIA | GHMFDVVVIG | GGISGLSAAK | LLTEYGVSVL | VLEARDRVGG | 
    100:
    RTYTIRNEHV | DYVDVGGAYV | GPTQNRILRL | SKELGIETYK | VNVSERLVQY | 
    150:
    VKGKTYPFRG | AFPPVWNPIA | YLDYNNLWRT | IDNMGKEIPT | DAPWEAQHAD | 
    200:
    KWDKMTMKEL | IDKICWTKTA | RRFAYLFVNI | NVTSEPHEVS | ALWFLWYVKQ | 
    250:
    CGGTTRIFSV | TNGGQERKFV | GGSGQVSERI | MDLLGDQVKL | NHPVTHVDQS | 
    300:
    SDNIIIETLN | HEHYECKYVI | NAIPPTLTAK | IHFRPELPAE | RNQLIQRLPM | 
    350:
    GAVIKCMMYY | KEAFWKKKDY | CGCMIIEDED | APISITLDDT | KPDGSLPAIM | 
    400:
    GFILARKADR | LAKLHKEIRK | KKICELYAKV | LGSQEALHPV | HYEEKNWCEE | 
    450:
    QYSGGCYTAY | FPPGIMTQYG | RVIRQPVGRI | FFAGTETATK | WSGYMEGAVE | 
    500:
    AGERAAREVL | NGLGKVTEKD | IWVQEPESKD | VPAVEITHTF | WERNLPSVSG | 
    527:
    LLKIIGFSTS | VTALGFVLYK | YKLLPRS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    MIM:
    SMR:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Amine oxidase [flavin-containing] A
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    E0661r
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    ELISA Kit for Human Amine oxidase [flavin-containing] A
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    E0661h
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    ELISA Kit for Human Amine oxidase [flavin-containing] A
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    E0661m
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    ELISA Kit for Human Amine oxidase [flavin-containing] A
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    E0661d
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    ELISA Kit for Human Amine oxidase [flavin-containing] A
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    E0661p
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    ELISA Kit for Human Amine oxidase [flavin-containing] A
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    E0661b
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    Packing:
    96T
    CLIA Kit for Human Amine oxidase [flavin-containing] A
    Cat.:
    U0661d
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    96T
    CLIA Kit for Human Amine oxidase [flavin-containing] A
    Cat.:
    U0661b
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    96T
    CLIA Kit for Human Amine oxidase [flavin-containing] A
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    U0661m
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    96T
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    CLIA Kit for Human Amine oxidase [flavin-containing] A
    Cat.:
    U0661r
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    Packing:
    96T
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    CLIA Kit for Human Amine oxidase [flavin-containing] A
    Cat.:
    U0661h
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Amine oxidase [flavin-containing] A
    Cat.:
    U0661p
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    Packing:
    96T
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] A
    Cat.:
    P0661Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] A
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] A
    Cat.:
    P0661Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] A
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] A
    Cat.:
    P0661Rb-r
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] A
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] A
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] A
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] A
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] A
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] A
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] A
    Protein for Human Amine oxidase [flavin-containing] A
    Protein for Human Amine oxidase [flavin-containing] A
    Protein for Human Amine oxidase [flavin-containing] A
    Protein for Human Amine oxidase [flavin-containing] A
    Protein for Human Amine oxidase [flavin-containing] A
    Protein for Human Amine oxidase [flavin-containing] A

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Structural features of human monoamine oxidase A elucidated from cDNA and peptide sequences."
      Hsu Y.-P.P. , Weyler W. , Chen S. , Sims K.B. , Rinehart W.B. , Utterback M.C. , Powell J.F. , Breakefield X.O.
      J. Neurochem.51:1321-1324(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties."
      Bach A.W.J. , Lan N.C. , Johnson D.L. , Abell C.W. , Bembenek M.E. , Kwan S.W. , Seeburg P.H. , Shih J.C.
      Proc. Natl. Acad. Sci. U.S.A.85:4934-4938(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Liver.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      "Human monoamine oxidase A and B genes exhibit identical exon-intron organization."
      Grimsby J. , Chen K. , Wang L.J. , Lan N.C. , Shih J.C.
      Proc. Natl. Acad. Sci. U.S.A.88:3637-3641(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Cerebellum.
    6. 6.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Ovary.
    8. 8.
      "Promoter organization and activity of human monoamine oxidase (MAO) A and B genes."
      Zhu Q.S. , Grimsby J.S. , Chen K. , Shih J.C.
      J. Neurosci.12:4437-4446(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24
    9. 9.
      "The promoter of the human monoamine oxidase A gene."
      Denney R.M.
      Prog. Brain Res.106:57-66(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-27
    10. 10.
      "A new look at the promoter of the human monoamine oxidase A gene: mapping transcription initiation sites and capacity to drive luciferase expression."
      Denney R.M. , Sharma A. , Dave S.K. , Waguespack A.
      J. Neurochem.63:843-856(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-33
    11. 11.
      "Partial amino acid sequence analysis of human placenta monoamine oxidase A and bovine liver monoamine oxidase B."
      Chen S.-Y. , Weyler W.
      Biochem. Biophys. Res. Commun.156:445-450(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 31-45; 62-78; 109-129; 268-288; 298-315; 318-332; 336-352; 372-412; 430-440 AND 458-493
      tissue: Placenta.
    12. 12.
      "Monoamine oxidase A from human placenta and monoamine oxidase B from bovine liver both have one FAD per subunit."
      Weyler W.
      Biochem. J.260:725-729(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DETERMINATION OF PROTEIN-FAD RATIO
      tissue: Placenta.
    13. 13.
      "High-level expression of human liver monoamine oxidase A in Pichia pastoris: comparison with the enzyme expressed in Saccharomyces cerevisiae."
      Li M. , Hubalek F. , Newton-Vinson P. , Edmondson D.E.
      Protein Expr. Purif.24:152-162(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;ACETYLATION AT MET-1;MASS SPECTROMETRY
    14. 14.
      "Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines."
      Wu H.F. , Chen K. , Shih J.C.
      Mol. Pharmacol.43:888-893(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-165; CYS-266; CYS-306; CYS-321; CYS-323; CYS-374; CYS-398 AND CYS-406
    15. 15.
      "Abnormal behavior associated with a point mutation in the structural gene for monoamine oxidase A."
      Brunner H.G. , Nelen M. , Breakefield X.O. , Ropers H.-H. , van Oost B.A.
      Science262:578-580(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN BRUNNER SYNDROME
    16. 16.
      "A functional polymorphism in the monoamine oxidase A gene promoter."
      Sabol S.Z. , Hu S. , Hamer D.
      Hum. Genet.103:273-279(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM IN THE PROMOTER REGION
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS);COFACTOR;SUBUNIT
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      "Structure of human monoamine oxidase A at 2.2-A resolution: the control of opening the entry for substrates/inhibitors."
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.17 ANGSTROMS) OF 12-524 IN COMPLEX WITH FAD AND THE INHIBITOR HARMINE;COFACTOR;TOPOLOGY
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      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLU-15
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