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Index > Protein center > MAOB(Gene name) > Human
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  • MAOB (Gene name),
  • Amine oxidase [flavin-containing] B (Protein name ),  AOFB_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MAOB;
    Protein name:
    Amine oxidase [flavin-containing] B;
    Alternative:
    Monoamine oxidase type B(MAO-B);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer, homo- or heterodimer (containing two subunits of similar size). Each subunit contains a covalently bound flavin. Enzymatically active as monomer.
    Function:
    Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine.
    Subcellular Location:
    Mitochondrion outer membrane Single-pass type IV membrane protein Cytoplasmic side
    Protein Attributes:
    Sequence length:
    520
    Sequence:
    50:
    MSNKCDVVVV | GGGISGMAAA | KLLHDSGLNV | VVLEARDRVG | GRTYTLRNQK | 
    100:
    VKYVDLGGSY | VGPTQNRILR | LAKELGLETY | KVNEVERLIH | HVKGKSYPFR | 
    150:
    GPFPPVWNPI | TYLDHNNFWR | TMDDMGREIP | SDAPWKAPLA | EEWDNMTMKE | 
    200:
    LLDKLCWTES | AKQLATLFVN | LCVTAETHEV | SALWFLWYVK | QCGGTTRIIS | 
    250:
    TTNGGQERKF | VGGSGQVSER | IMDLLGDRVK | LERPVIYIDQ | TRENVLVETL | 
    300:
    NHEMYEAKYV | ISAIPPTLGM | KIHFNPPLPM | MRNQMITRVP | LGSVIKCIVY | 
    350:
    YKEPFWRKKD | YCGTMIIDGE | EAPVAYTLDD | TKPEGNYAAI | MGFILAHKAR | 
    400:
    KLARLTKEER | LKKLCELYAK | VLGSLEALEP | VHYEEKNWCE | EQYSGGCYTT | 
    450:
    YFPPGILTQY | GRVLRQPVDR | IYFAGTETAT | HWSGYMEGAV | EAGERAAREI | 
    500:
    LHAMGKIPED | EIWQSEPESV | DVPAQPITTT | FLERHLPSVP | GLLRLIGLTT | 
    520:
    IFSATALGFL | AHKRGLLVRV | 
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    SMR:
    String:
    KEGG:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Amine oxidase [flavin-containing] B
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    E9775h
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    ELISA Kit for Human Amine oxidase [flavin-containing] B
    MSDS:
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    ELISA Kit for Human Amine oxidase [flavin-containing] B
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    E9775r
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    96T
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    ELISA Kit for Human Amine oxidase [flavin-containing] B
    Cat.:
    E9775m
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    ELISA Kit for Human Amine oxidase [flavin-containing] B
    MSDS:
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    ELISA Kit for Human Amine oxidase [flavin-containing] B
    Cat.:
    E9775p
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    Packing:
    96T
    CLIA Kit for Human Amine oxidase [flavin-containing] B
    Cat.:
    U9775p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Amine oxidase [flavin-containing] B
    Cat.:
    U9775r
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Amine oxidase [flavin-containing] B
    Cat.:
    U9775m
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Human Amine oxidase [flavin-containing] B
    MSDS:
    Please sign in first.
    CLIA Kit for Human Amine oxidase [flavin-containing] B
    Cat.:
    U9775b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Amine oxidase [flavin-containing] B
    Cat.:
    U9775h
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] B
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] B
    Cat.:
    P9775Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] B
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] B
    Cat.:
    P9775Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] B
    Polyclonal Antibody for Human Amine oxidase [flavin-containing] B
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] B
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] B
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] B
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] B
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] B
    Monoclonal Antibody for Human Amine oxidase [flavin-containing] B
    Protein for Human Amine oxidase [flavin-containing] B
    Protein for Human Amine oxidase [flavin-containing] B
    Protein for Human Amine oxidase [flavin-containing] B
    Protein for Human Amine oxidase [flavin-containing] B
    Protein for Human Amine oxidase [flavin-containing] B
    Protein for Human Amine oxidase [flavin-containing] B

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    Linearity

     

     

     

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    References
    1. 1.
      "Human monoamine oxidase A and B genes exhibit identical exon-intron organization."
      Grimsby J. , Chen K. , Wang L.J. , Lan N.C. , Shih J.C.
      Proc. Natl. Acad. Sci. U.S.A.88:3637-3641(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "cDNA cloning of human liver monoamine oxidase A and B: molecular basis of differences in enzymatic properties."
      Bach A.W.J. , Lan N.C. , Johnson D.L. , Abell C.W. , Bembenek M.E. , Kwan S.W. , Seeburg P.H. , Shih J.C.
      Proc. Natl. Acad. Sci. U.S.A.85:4934-4938(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "The deduced amino acid sequences of human platelet and frontal cortex monoamine oxidase B are identical."
      Chen K. , Wu H.F. , Shih J.C.
      J. Neurochem.61:187-190(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
    5. 5.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "Promoter organization and activity of human monoamine oxidase (MAO) A and B genes."
      Zhu Q.S. , Grimsby J.S. , Chen K. , Shih J.C.
      J. Neurosci.12:4437-4446(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-15
    8. 8.
      "High-level expression of human liver monoamine oxidase B in Pichia pastoris."
      Newton-Vinson P. , Hubalek F. , Edmondson D.E.
      Protein Expr. Purif.20:334-345(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-17;ACETYLATION AT SER-2;MASS SPECTROMETRY
    9. 9.
      "Investigation on the structure of the active site of monoamine oxidase-B by affinity labeling with the selective inhibitor lazabemide and by site-directed mutagenesis."
      Cesura A.M. , Gottowik J. , Lahm H.-W. , Lang G. , Imhof R. , Malherbe P. , Roethlisberger U. , Da Prada M.
      Eur. J. Biochem.236:996-1002(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 371-391;MUTAGENESIS OF THR-158; HIS-382; LYS-386; CYS-389 AND SER-394
    10. 10.
      "Site-directed mutagenesis of monoamine oxidase A and B: role of cysteines."
      Wu H.F. , Chen K. , Shih J.C.
      Mol. Pharmacol.43:888-893(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF CYS-5; CYS-156; CYS-172; CYS-192; CYS-297; CYS-312; CYS-365; CYS-389 AND CYS-397
    11. 11.
      "Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders."
      Binda C. , Newton-Vinson P. , Hubalek F. , Edmondson D.E. , Mattevi A.
      Nat. Struct. Biol.9:22-26(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS)
    12. 12.
      "Insights into the mode of inhibition of human mitochondrial monoamine oxidase B from high-resolution crystal structures."
      Binda C. , Li M. , Hubalek F. , Restelli N. , Edmondson D.E. , Mattevi A.
      Proc. Natl. Acad. Sci. U.S.A.100:9750-9755(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) IN COMPLEXES WITH INHIBITORS
    13. 13.
      "Crystal structures of monoamine oxidase B in complex with four inhibitors of the N-propargylaminoindan class."
      Binda C. , Hubalek F. , Li M. , Herzig Y. , Sterling J. , Edmondson D.E. , Mattevi A.
      J. Med. Chem.47:1767-1774(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) IN COMPLEXES WITH INHIBITORS
    14. 14.
      "Demonstration of isoleucine 199 as a structural determinant for the selective inhibition of human monoamine oxidase B by specific reversible inhibitors."
      Hubalek F. , Binda C. , Khalil A. , Li M. , Mattevi A. , Castagnoli N. , Edmondson D.E.
      J. Biol. Chem.280:15761-15766(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF MUTANT PHE-199 IN COMPLEXES WITH INHIBITORS
    15. 15.
      "Binding of rasagiline-related inhibitors to human monoamine oxidases: a kinetic and crystallographic analysis."
      Binda C. , Hubalek F. , Li M. , Herzig Y. , Sterling J. , Edmondson D.E. , Mattevi A.
      J. Med. Chem.48:8148-8154(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEXES WITH INHIBITORS
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