Gene name:
AP1AR(PRO0971;C4orf16);
Protein name:
AP-1 complex-associated regulatory protein;
Alternative:
Adapter-related protein complex 1-associated regulatory protein;2c18;Gamma-A1-adaptin and kinesin interactor(Gadkin);Gamma-1-adaptin brefeldin A resistance protein(GBAR;Gamma-BAR);
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts (via coiled-coil domain) with AP1G1 (via GAE domain).
Function:
Necessary for AP-1 dependent transport between the trans-Golgi network and endosomes. Regulates the membrane association of AP1G1/Gamma1-adaptin, one of the subunits of the AP-1 adapter complex. The direct interaction with AP1G1/Gamma1-adaptin attenuates the release of the AP-1 complex from membranes.
Subcellular Location:
Golgi apparatus
trans-Golgi network
Late endosome
Early endosome
Localizes to the juxta-nuclear Golgi region and to tubular structures throughout the cytoplasm, which are highly mobile and cycle between the juxta-nuclear area and the cell periphery.
Protein Attributes:
50:
MGNCCWTQCF | GLLRKEAGRL | QRVGGGGGSK | YFRTCSRGEH | LTIEFENLVE |
100:
SDEGESPGSS | HRPLTEEEIV | DLRERHYDSI | AEKQKDLDKK | IQKELALQEE |
150:
KLRLEEEALY | AAQREAARAA | KQRKLLEQER | QRIVQQYHPS | NNGEYQSSGP |
200:
EDDFESCLRN | MKSQYEVFRS | SRLSSDATVL | TPNTESSCDL | MTKTKSTSGN |
250:
DDSTSLDLEW | EDEEGMNRML | PMRERSKTEE | DILRAALKYS | NKKTGSNPTS |
300:
ASDDSNGLEW | ENDFVSAEMD | DNGNSEYSGF | VNPVLELSDS | GIRHSDTDQQ |
Vaild Sequence:
Related Databases
Uniprot:
