Protein name:
Apolipoprotein A-I (Apo-AI;ApoA-I) ;
Alternative:
Apolipoprotein A1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin.
Function:
Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility.
Subcellular Location:
Secreted
Protein Attributes:
50:
MKAAVLTLAV | LFLTGSQARH | FWQQDEPPQS | PWDRVKDLAT | VYVDVLKDSG |
100:
RDYVSQFEGS | ALGKQLNLKL | LDNWDSVTST | FSKLREQLGP | VTQEFWDNLE |
150:
KETEGLRQEM | SKDLEEVKAK | VQPYLDDFQK | KWQEEMELYR | QKVEPLRAEL |
200:
QEGARQKLHE | LQEKLSPLGE | EMRDRARAHV | DALRTHLAPY | SDELRQRLAA |
250:
RLEALKENGG | ARLAEYHAKA | TEHLSTLSEK | AKPALEDLRQ | GLLPVLESFK |
267:
VSFLSALEEY | TKKLNTQ
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Rabbit
Pig
Dog
Bovine
Chicken
ELISA Kit for Human Apo-AI
ELISA Kit for Human Apo-AI
ELISA Kit for Human Apo-AI
ELISA Kit for Human Apo-AI
ELISA Kit for Human Apo-AI
ELISA Kit for Human Apo-AI
ELISA Kit for Human Apo-AI
ELISA Kit for Human Apo-AI
CLIA Kit for Human Apo-AI
CLIA Kit for Human Apo-AI
CLIA Kit for Human Apo-AI
CLIA Kit for Human Apo-AI
CLIA Kit for Human Apo-AI
CLIA Kit for Human Apo-AI
CLIA Kit for Human Apo-AI
CLIA Kit for Human Apo-AI
Polyclonal Antibody for Human Apo-AI
Polyclonal Antibody for Human Apo-AI
Polyclonal Antibody for Human Apo-AI
Polyclonal Antibody for Human Apo-AI
Polyclonal Antibody for Human Apo-AI
Polyclonal Antibody for Human Apo-AI
Polyclonal Antibody for Human Apo-AI
Polyclonal Antibody for Human Apo-AI
Monoclonal Antibody for Human Apo-AI
Monoclonal Antibody for Human Apo-AI
Monoclonal Antibody for Human Apo-AI
Monoclonal Antibody for Human Apo-AI
Monoclonal Antibody for Human Apo-AI
Monoclonal Antibody for Human Apo-AI
Monoclonal Antibody for Human Apo-AI
Monoclonal Antibody for Human Apo-AI
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (VARIANT TANGIER)
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Nat. Genet.36:40-45(2004)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Testis .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA]
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Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
15.
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
tissue :
Skeletal muscle .
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 19-27
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 25-267
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 25-267
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 25-56
20.
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Cited for : PROTEIN SEQUENCE OF 25-50;FUNCTION;IDENTIFICATION IN THE SPAP COMPLEX
tissue :
Serum .
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 25-48
22.
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Cited for : PROTEIN SEQUENCE OF 25-43
23.
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Cited for : PROTEIN SEQUENCE OF 25-42
tissue :
Heart .
24.
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Cited for : PROTEIN SEQUENCE OF 25-34
tissue :
Platelet .
25.
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Cited for : PROTEIN SEQUENCE OF 25-33;INTERACTION WITH APOA1BP AND CLU
26.
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Cited for : PROTEIN SEQUENCE OF 35-64; 70-101; 121-140; 165-173; 185-195 AND 240-263;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
Brain .
tissue :
Cajal-Retzius cell .
tissue :
Fetal brain cortex .
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 118-267
28.
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Cited for : PALMITOYLATION
29.
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Cited for : PROTEOLYTIC PROCESSING
30.
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Cited for : GLYCATION AT LYS-263
31.
"Cloning and characterization of a novel apolipoprotein A-I-binding protein, AI-BP, secreted by cells of the kidney proximal tubules in response to HDL or ApoA-I."
Ritter M.
,
Buechler C.
,
Boettcher A.
,
Barlage S.
,
Schmitz-Madry A.
,
Orso E.
,
Bared S.M.
,
Schmiedeknecht G.
,
Baehr C.H.
,
Fricker G.
,
Schmitz G.
Genomics79:693-702(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH APOA1BP
32.
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Cited for : MASS SPECTROMETRY;OXIDATION AT MET-110 AND MET-136;TISSUE SPECIFICITY
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NDRG1
35.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 190-209
37.
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Cited for : X-RAY CRYSTALLOGRAPHY (4.0 ANGSTROMS) OF 67-267
38.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISEASE
39.
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Cited for : DISEASE
40.
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Cited for : VARIANT MILANO CYS-197
41.
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Cited for : VARIANT TANGIER
42.
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Cited for : VARIANT GIESSEN ARG-167
43.
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Cited for : VARIANT NORWAY LYS-160
44.
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Cited for : PROTEIN SEQUENCE OF 25-107;VARIANT AMYL8 ARG-50
45.
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Cited for : VARIANT AMYL8 ARG-50
46.
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Cited for : PROTEIN SEQUENCE OF 25-267;VARIANT FUKUOKA LYS-134
47.
"Apolipoprotein AI mutation Arg-60 causes autosomal dominant amyloidosis."
Soutar A.K.
,
Hawkins P.N.
,
Vigushin D.M.
,
Tennent G.A.
,
Booth S.E.
,
Hutton T.
,
Nguyen O.
,
Totty N.F.
,
Feest T.G.
,
Hsuan J.J.
,
Pepys M.B.
Proc. Natl. Acad. Sci. U.S.A.89:7389-7393(1992)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : PROTEIN SEQUENCE OF 25-112;VARIANT AMYL8 ARG-84
48.
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Cited for : VARIANT BALTIMORE LEU-34
49.
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Cited for : VARIANTS ARG-27; ARG-28 AND ARG-189
50.
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Cited for : VARIANTS GLU-113; MET-131; GLY-163; VAL-171 AND LYS-222
51.
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Cited for : VARIANTS HITA AND TSUSHIMA
52.
"Familial nephropathic systemic amyloidosis caused by apolipoprotein AI variant Arg26."
Vigushin D.M.
,
Gough J.
,
Allan D.
,
Alguacil A.
,
Penner B.
,
Pettigrew N.M.
,
Quinonez G.
,
Bernstein K.
,
Booth S.E.
,
Booth D.R.
,
Soutar A.K.
,
Hawkins P.N.
,
Pepys M.B.
Q. J. Med.87:149-154(1994)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT AMYL8 ARG-50
53.
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Cited for : VARIANT AOITA GLU-180
54.
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Cited for : VARIANT ZARAGOZA ARG-168
55.
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Cited for : VARIANT ILE-92
56.
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Cited for : VARIANT ILE-92;IDENTIFICATION BY MASS SPECTROMETRY