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Index > Protein center > APOA4(Gene name) > Human
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  • APOA4 (Gene name),
  • Apolipoprotein A-IV (Protein name ),  APOA4_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    APOA4;
    Protein name:
    Apolipoprotein A-IV(Apo-AIV;ApoA-IV);
    Alternative:
    Apolipoprotein A4;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May have a role in chylomicrons and VLDL secretion and catabolism. Required for efficient activation of lipoprotein lipase by ApoC-II; potent activator of LCAT. Apoa-IV is a major component of HDL and chylomicrons.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    396
    Sequence:
    50:
    MFLKAVVLTL | ALVAVAGARA | EVSADQVATV | MWDYFSQLSN | NAKEAVEHLQ | 
    100:
    KSELTQQLNA | LFQDKLGEVN | TYAGDLQKKL | VPFATELHER | LAKDSEKLKE | 
    150:
    EIGKELEELR | ARLLPHANEV | SQKIGDNLRE | LQQRLEPYAD | QLRTQVNTQA | 
    200:
    EQLRRQLTPY | AQRMERVLRE | NADSLQASLR | PHADELKAKI | DQNVEELKGR | 
    250:
    LTPYADEFKV | KIDQTVEELR | RSLAPYAQDT | QEKLNHQLEG | LTFQMKKNAE | 
    300:
    ELKARISASA | EELRQRLAPL | AEDVRGNLRG | NTEGLQKSLA | ELGGHLDQQV | 
    350:
    EEFRRRVEPY | GENFNKALVQ | QMEQLRQKLG | PHAGDVEGHL | SFLEKDLRDK | 
    396:
    VNSFFSTFKE | KESQDKTLSL | PELEQQQEQQ | QEQQQEQVQM | LAPLES
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    SMR:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Apo-AIV
    Cat.:
    E1967h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Apo-AIV
    Cat.:
    E1967m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Apo-AIV
    Cat.:
    E1967b
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Apo-AIV
    Cat.:
    E1967p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Apo-AIV
    Cat.:
    E1967r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Apo-AIV
    Cat.:
    U1967p
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Apo-AIV
    Cat.:
    U1967b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Apo-AIV
    Cat.:
    U1967r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Apo-AIV
    Cat.:
    U1967m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Apo-AIV
    Cat.:
    U1967h
    Price:
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human Apo-AIV
    Cat.:
    P1967Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Apo-AIV
    Cat.:
    P1967Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Apo-AIV
    Polyclonal Antibody for Human Apo-AIV
    Cat.:
    P1967Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Apo-AIV
    Monoclonal Antibody for Human Apo-AIV
    Monoclonal Antibody for Human Apo-AIV
    Monoclonal Antibody for Human Apo-AIV
    Monoclonal Antibody for Human Apo-AIV
    Monoclonal Antibody for Human Apo-AIV
    Protein for Human Apo-AIV
    Protein for Human Apo-AIV
    Protein for Human Apo-AIV
    Protein for Human Apo-AIV
    Protein for Human Apo-AIV

    R&D Technical Data
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    Precision
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    Linearity
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    References
    1. 1.
      "Structure, evolution, and tissue-specific synthesis of human apolipoprotein AIV."
      Karathanasis S.K. , Yunis I.
      Biochemistry25:3962-3970(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LYS-279
    2. 2.
      "Structure, evolution, and polymorphisms of the human apolipoprotein A4 gene (APOA4)."
      Karathanasis S.K. , Oettgen P. , Haddad I.A. , Antonarakis S.E.
      Proc. Natl. Acad. Sci. U.S.A.83:8457-8461(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LYS-279
    3. 3.
      "Structure and expression of the human apolipoprotein A-IV gene."
      Elshourbagy N.A. , Walker D.W. , Paik Y.K. , Boguski M.S. , Freeman M. , Gordon J.I. , Taylor J.M.
      J. Biol. Chem.262:7973-7981(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT APOA-IV*2 HIS-380
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Intestine.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS MET-13; HIS-77; SER-147; SER-161; SER-367 AND HIS-380
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT SER-147
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
      tissue: Colon.
    8. 8.
      "The nucleotide and derived amino acid sequence of human apolipoprotein A-IV mRNA and the close linkage of its gene to the genes of apolipoproteins A-I and C-III."
      Elshourbagy N.A. , Walker D.W. , Boguski M.S. , Gordon J.I. , Taylor J.M.
      J. Biol. Chem.261:1998-2002(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 21-396;VARIANT APOA-IV*2 HIS-380
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SIGNAL SEQUENCE CLEAVAGE SITE
    10. 10.
      "Genetic polymorphism of apolipoprotein A-IV."
      Lohse P. , Brewer H.B. Jr.
      Curr. Opin. Lipidol.2:90-95(1991)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON POLYMORPHISM
    11. 11.
      "Genetic polymorphism of human plasma apolipoprotein A-IV is due to nucleotide substitutions in the apolipoprotein A-IV gene."
      Lohse P. , Kindt M.R. , Rader D.J. , Brewer H.B. Jr.
      J. Biol. Chem.265:10061-10064(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALLELES APOA-IV*1 AND APOA-IV*2;VARIANT HIS-380
    12. 12.
      "Human plasma apolipoproteins A-IV-0 and A-IV-3. Molecular basis for two rare variants of apolipoprotein A-IV-1."
      Lohse P. , Kindt M.R. , Rader D.J. , Brewer H.B. Jr.
      J. Biol. Chem.265:12734-12739(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALLELES A-IV*0 AND A-IV*3;VARIANTS LYS-250 AND GLU-GLN-GLN-GLN-381 INS
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      "The structure of dimeric apolipoprotein A-IV and its mechanism of self-association."
      Deng X. , Morris J. , Dressmen J. , Tubb M.R. , Tso P. , Jerome W.G. , Davidson W.S. , Thompson T.B.
      Structure20:767-779(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 84-355;SUBUNIT
    15. 15.
      "The mutation causing the common apolipoprotein A-IV polymorphism is a glutamine to histidine substitution of amino acid 360."
      Tenkanen H. , Lukka M. , Jauhiainen M. , Metso J. , Baumann M. , Peltonen L. , Ehnholm C.
      Arterioscler. Thromb.11:851-856(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-380
    16. 16.
      "Three genetic variants of human plasma apolipoprotein A-IV: apoA-IV-1(Thr-347-->Ser), apoA-IV-0(Lys-167-->Glu,Gln-360-->His), and apoA-IV-3(Glu-165-->Lys)."
      Lohse P. , Kindt M.R. , Rader D.J. , Brewer H.B. Jr.
      J. Biol. Chem.266:13513-13518(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALLELES A-IV*0; A-IV*1; A-IV*2 AND A-IV*3;VARIANTS LYS-185; GLU-187; SER-367 AND HIS-380
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    18. 18.
      "Nonsynonymous polymorphic sites in the apolipoprotein (apo) A-IV gene are associated with changes in the concentration of apo B- and apo A-I-containing lipoproteins in a normal population."
      von Eckardstein A. , Funke H. , Schulte M. , Erren M. , Schulte H. , Assmann G.
      Am. J. Hum. Genet.50:1115-1128(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-13
    19. 19.
      "A novel polymorphism of apolipoprotein A-IV is the result of an asparagine to serine substitution at residue 127."
      Tenkanen H. , Koskinen P. , Metso J. , Baumann M. , Lukka M. , Kauppinen-Makelin R. , Kontula K. , Taskinen M.R. , Manttari M. , Manninen V. , Ehnholm C.
      Biochim. Biophys. Acta1138:27-33(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SER-147
    20. 20.
      "Molecular basis of a unique African variant (A-IV 5) of human apolipoprotein A-IV and its significance in lipid metabolism."
      Kamboh M.I. , Williams E.R. , Law J.C. , Aston C.E. , Bunker C.H. , Ferrell R.E. , Pollitzer W.S.
      Genet. Epidemiol.9:379-388(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALLELE A-IV*5;VARIANT GLU-GLN-GLN-GLN-381 INS
    21. 21.
      "Apolipoprotein A-IV polymorphism in the Hungarian population: gene frequencies, effect on lipid levels, and sequence of two new variants."
      Menzel H.J. , Dieplinger H. , Sandholzer C. , Karadi I. , Utermann G. , Csaszar A.
      Hum. Mutat.5:58-65(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS BUDAPEST-2 LYS-44; BUDAPEST-1 CYS-305 AND SER-367
    22. 22.
      "Two novel apolipoprotein A-IV variants in individuals with familial combined hyperlipidemia and diminished levels of lipoprotein lipase activity."
      Deeb S.S. , Nevin D.N. , Iwasaki L. , Brunzell J.D.
      Hum. Mutat.8:319-325(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SEATTLE-3 SER-161; SEATTLE-1 LEU-178 AND SEATTLE-2 GLN-264
    23. 23.
      "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
      Halushka M.K. , Fan J.-B. , Bentley K. , Hsie L. , Shen N. , Weder A. , Cooper R. , Lipshutz R. , Chakravarti A.
      Nat. Genet.22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HIS-380
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