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Index > Protein center > APOC2(Gene name) > Human
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  • APOC2 (Gene name),
  • Apolipoprotein C-II (Protein name ),  APOC2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Vaild Sequence
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  • Gene name:
    APOC2(APC2);
    Protein name:
    Apolipoprotein C-II(Apo-CII;ApoC-II);
    Alternative:
    Apolipoprotein C2;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Component of the very low density lipoprotein (VLDL) fraction in plasma, and is an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    101
    Sequence:
    50:
    MGTRLLPALF | LVLLVLGFEV | QGTQQPQQDE | MPSPTFLTQV | KESLSSYWES | 
    100:
    AKTAAQNLYE | KTYLPAVDEK | LRDLYSKSTA | AMSTYTGIFT | DQVLSVLKGE | 
    101:
    E
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    Pfam:
    String:
    MIM:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Human Apo-CII
    Cat.:
    E1996h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Apo-CII
    Cat.:
    E1996d
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Apo-CII
    Cat.:
    E1996m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human Apo-CII
    Cat.:
    E1996b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Apo-CII
    Cat.:
    U1996m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Apo-CII
    Cat.:
    U1996h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Apo-CII
    Cat.:
    U1996d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human Apo-CII
    Cat.:
    U1996b
    Price:
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    Packing:
    96T
    Polyclonal Antibody for Human Apo-CII
    Cat.:
    P1996Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Apo-CII
    Cat.:
    P1996Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Apo-CII
    Polyclonal Antibody for Human Apo-CII
    Monoclonal Antibody for Human Apo-CII
    Monoclonal Antibody for Human Apo-CII
    Monoclonal Antibody for Human Apo-CII
    Monoclonal Antibody for Human Apo-CII
    Protein for Human Apo-CII
    Protein for Human Apo-CII
    Protein for Human Apo-CII
    Protein for Human Apo-CII

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    Linearity
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    References
    1. 1.
      "The human preproapolipoprotein C-II gene. Complete nucleic acid sequence and genomic organization."
      Fojo S.S. , Law S.W. , Brewer H.B. Jr.
      FEBS Lett.213:221-226(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    2. 2.
      "Human apolipoprotein C-II: complete nucleic acid sequence of preapolipoprotein C-II."
      Fojo S.S. , Law S.W. , Brewer H.B. Jr.
      Proc. Natl. Acad. Sci. U.S.A.81:6354-6357(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    3. 3.
      "Human apolipoproteins AI, AII, CII and CIII. cDNA sequences and mRNA abundance."
      Sharpe C.R. , Sidoli A. , Shelley C.S. , Lucero M.A. , Shoulders C.C. , Baralle F.E.
      Nucleic Acids Res.12:3917-3932(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    4. 4.
      "The human apolipoprotein C-II gene sequence contains a novel chromosome 19-specific minisatellite in its third intron."
      Das H.K. , Jackson C.L. , Miller D.A. , Leff T. , Breslow J.L.
      J. Biol. Chem.262:4787-4793(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "The structure of the human apolipoprotein C-II gene. Electron microscopic analysis of RNA:DNA hybrids, complete nucleotide sequence, and identification of 5' homologous sequences among apolipoprotein genes."
      Wei C.F. , Tsao Y.K. , Robberson D.L. , Gotto A.M. Jr. , Brown K. , Chan L.
      J. Biol. Chem.260:15211-15221(1985) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
    6. 6.
      Nickerson D.A. , Smith J.D. , Fullerton S.M. , Clark A.G. , Stengard J.H. , Salomaa V. , Boerwinkle E. , Sing C.F. , Weiss K.M.
      Submitted (2003-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    7. 7.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    8. 8.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2008-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Skeletal muscle.
    11. 11.
      "The isolation and characterization of cDNA clones for human apolipoprotein CII."
      Myklebost O. , Williamson B. , Markham A.F. , Myklebost S.R. , Rogers J. , Woods D.E. , Humphries S.E.
      J. Biol. Chem.259:4401-4404(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-101;TISSUE SPECIFICITY
    12. 12.
      "Isolation of cDNA and genomic clones for apolipoprotein C-II."
      Jackson C.L. , Bruns G.A.P. , Breslow J.L.
      Methods Enzymol.128:788-800(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 11-101
    13. 13.
      "Amino acid sequence of human plasma apolipoprotein C-II from normal and hyperlipoproteinemic subjects."
      Hospattankar A.V. , Fairwell T. , Ronan R. , Brewer H.B. Jr.
      J. Biol. Chem.259:318-322(1984) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-101
    14. 14.
      "Primary structure of very low density apolipoprotein C-II of human plasma."
      Jackson R.L. , Baker H.N. , Gilliam E.B. , Gotto A.M. Jr.
      Proc. Natl. Acad. Sci. U.S.A.74:1942-1945(1977) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 23-101
    15. 15.
      "Human preproapolipoprotein C-II. Analysis of major plasma isoforms."
      Fojo S.S. , Taam L. , Fairwell T. , Ronan R. , Bishop C. , Meng M.S. , Hoeg J.M. , Sprecher D.L. , Brewer H.B. Jr.
      J. Biol. Chem.261:9591-9594(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 29-35;PROTEOLYTIC PROCESSING;GLYCOSYLATION;SUBCELLULAR LOCATION
    16. 16.
      "Expression of the apolipoprotein C-II gene during myelomonocytic differentiation of human leukemic cells."
      Chun E.M. , Park Y.J. , Kang H.S. , Cho H.M. , Jun D.Y. , Kim Y.H.
      J. Leukoc. Biol.69:645-650(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 77-101
    17. 17.
      "Primary structure of the bovine analogues to human apolipoproteins CII and CIII. Studies on isoforms and evidence for proteolytic processing."
      Bengtsson-Olivecrona G. , Sletten K.
      Eur. J. Biochem.192:515-521(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    18. 18.
      "A review of the role of apolipoprotein C-II in lipoprotein metabolism and cardiovascular disease."
      Kei A.A. , Filippatos T.D. , Tsimihodimos V. , Elisaf M.S.
      Metabolism61:906-921(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    19. 19.
      "LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
      Halim A. , Ruetschi U. , Larson G. , Nilsson J.
      J. Proteome Res.12:573-584(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;IDENTIFICATION BY MASS SPECTROMETRY
    20. 20.
      "Sequence specific 1H-NMR assignments and secondary structure of a carboxy-terminal functional fragment of apolipoprotein CII."
      Lycksell P.-O. , Oehman A. , Bengtsson-Olivecrona G. , Johansson L.B.-A. , Wijmenga S.S. , Wernic D. , Graeslund A.
      Eur. J. Biochem.205:223-231(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 72-101
    21. 21.
      "A refined three-dimensional solution structure of a carboxy terminal fragment of apolipoprotein CII."
      Oehman A. , Lycksell P.-O. , Graeslund A.
      Eur. Biophys. J.22:351-357(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 72-101
    22. 22.
      "A variant primary structure of apolipoprotein C-II in individuals of African descent."
      Menzel H.-J. , Kane J.P. , Malloy M.J. , Havel R.J.
      J. Clin. Invest.77:595-601(1986) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT AFRICA GLN-77
    23. 23.
      "Molecular cloning and characteristics of a new apolipoprotein C-II mutant identified in three unrelated individuals with hypercholesterolemia and hypertriglyceridemia."
      Pullinger C.R. , Zysow B.R. , Hennessy L.K. , Frost P.H. , Malloy M.J. , Kanr J.P.
      Hum. Mol. Genet.2:69-74(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SAN FRANCISCO LYS-60
    24. 24.
      "An apolipoprotein CII mutation, CII Lys-19-->Thr identified in patients with hyperlipidemia."
      Hegele R.A. , Connelly P.W. , Maguire G.F. , Huff M.W. , Leiter L. , Wolfe B.M. , Evans A.J. , Little J.A.
      Dis. Markers9:73-80(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-41
    25. 25.
      "The apolipoprotein C-II variant apoC-II Lys-19-->Thr is not associated with dyslipidemia in an affected kindred."
      Zysow B.R. , Pullinger C.R. , Hennessy L.K. , Farese R.V. Jr. , Ghassemzadeh M. , Kane J.P.
      Clin. Genet.45:292-297(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT THR-41
    26. 26.
      "A missense mutation (Trp 26-->Arg) in exon 3 of the apolipoprotein CII gene in a patient with apolipoprotein CII deficiency (apo CII-Wakayama)."
      Inadera H. , Hibino A. , Kobayashi J. , Kanzaki T. , Shirai K. , Yukawa S. , Saito Y. , Yoshida S.
      Biochem. Biophys. Res. Commun.193:1174-1183(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HLPP1B WAKAYAMA ARG-48
    27. 27.
      "Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis."
      Halushka M.K. , Fan J.-B. , Bentley K. , Hsie L. , Shen N. , Weder A. , Cooper R. , Lipshutz R. , Chakravarti A.
      Nat. Genet.22:239-247(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GLN-77
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