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Index > Protein center > Aptx(Gene name) > Mouse
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  • Aptx (Gene name),
  • Aprataxin (Protein name ),  APTX_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Aptx;
    Protein name:
    Aprataxin;
    Alternative:
    Forkhead-associated domain histidine triad-like protein(FHA-HIT);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with single-strand break repair proteins XRCC1, XRCC4, ADPRT and p53/TP53. Interacts with NCL. Interacts (via FHA-like domain) with MDC1 (phosphorylated).
    Function:
    DNA-binding protein involved in single-strand DNA break repair, double-strand DNA break repair and base excision repair. Resolves abortive DNA ligation intermediates formed either at base excision sites, or when DNA ligases attempt to repair non-ligatable breaks induced by reactive oxygen species. Catalyzes the release of adenylate groups covalently linked to 5'-phosphate termini, resulting in the production of 5'-phosphate termini that can be efficiently rejoined. Also able to hydrolyze adenosine 5'-monophosphoramidate (AMP-NH2) and diadenosine tetraphosphate (AppppA), but with lower catalytic activity.
    Subcellular Location:
    Nucleus nucleoplasm Nucleus nucleolus Upon genotoxic stress, colocalizes with XRCC1 at sites of DNA damage. Colocalizes with MDC1 at sites of DNA double-strand breaks. Interaction with NCL is required for nucleolar localization.
    Protein Attributes:
    Sequence length:
    342
    Sequence:
    50:
    MPEAVAKMRV | CWLVRQDSRH | QRIKLPHLEA | VVIGRSPETK | ITDKKCSRQQ | 
    100:
    VQLKAECNKG | YVKVQQMGVN | PTSIDSGVIG | KDQEKKLLPG | QVLHMVNGLY | 
    150:
    PYIVEFEEVA | ESPNLTQRKR | KRSDCDSEEM | EAESGTGLAP | GSSPSQCSVS | 
    200:
    PKKDKNGATK | KESLGHWSQG | LKMSMKDPKM | QVYKDDQVVV | IKDKYPKARH | 
    250:
    HWLVLPWASI | SSLKVVTSEH | LELLKHMHAV | GEKVIADFAG | SSKLRFRLGY | 
    300:
    HAIPSMSHVH | LHVISQDFDS | PCLKNKKHWN | SFNTEYFLES | QAVIKMVQEA | 
    342:
    GRVTVKDGTC | ELLKLPLRCH | ECQQLLPSIP | QLKEHLRKHW | GG
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    KEGG:
    String:
    SMR:
    Uniprot:
     
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    Polyclonal Antibody for Mouse Aprataxin
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    P9623Rb-h
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    Polyclonal Antibody for Mouse Aprataxin
    Polyclonal Antibody for Mouse Aprataxin
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    Polyclonal Antibody for Mouse Aprataxin
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    Monoclonal Antibody for Mouse Aprataxin
    Monoclonal Antibody for Mouse Aprataxin
    Monoclonal Antibody for Mouse Aprataxin
    Monoclonal Antibody for Mouse Aprataxin
    Monoclonal Antibody for Mouse Aprataxin
    Monoclonal Antibody for Mouse Aprataxin
    Monoclonal Antibody for Mouse Aprataxin
    Protein for Mouse Aprataxin
    Protein for Mouse Aprataxin
    Protein for Mouse Aprataxin
    Protein for Mouse Aprataxin
    Protein for Mouse Aprataxin
    Protein for Mouse Aprataxin
    Protein for Mouse Aprataxin

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    References
    1. 1.
      "Identification of FHA-HIT as a novel nuclear protein involved in cell-cycle regulation."
      Huang C.-H.
      Submitted (2001-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
      strain: BALB/c.
      strain: C57BL/6J.
    2. 2.
      "Differential polyadenylation of mouse FHA-HIT transcript."
      Chen Y. , Huang C.-H.
      Submitted (2002-12) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2; 3 AND 4)
      strain: C57BL/6J.
      strain: NOD.
      tissue: Cerebellum.
      tissue: Embryonic stem cell.
      tissue: Pituitary.
      tissue: Thymus.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      strain: Czech II.
      tissue: Mammary tumor.
    5. 5.
      "The gene mutated in ataxia-ocular apraxia 1 encodes the new HIT/Zn-finger protein aprataxin."
      Moreira M.-C. , Barbot C. , Tachi N. , Kozuka N. , Uchida E. , Gibson T. , Mendonca P. , Costa M. , Barros J. , Yanagisawa T. , Watanabe M. , Ikeda Y. , Aoki M. , Nagata T. , Coutinho P. , Sequeiros J. , Koenig M.
      Nat. Genet.29:189-193(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      "The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates."
      Ahel I. , Rass U. , El-Khamisy S.F. , Katyal S. , Clements P.M. , McKinnon P.J. , Caldecott K.W. , West S.C.
      Nature443:713-716(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
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