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Index > Protein center > AQP1(Gene name) > Human
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  • AQP1 (Gene name),
  • Aquaporin-1 (Protein name ),  AQP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    AQP1(CHIP28);
    Protein name:
    Aquaporin-1(AQP-1);
    Alternative:
    Urine water channel;Aquaporin-CHIP;Water channel protein for red blood cells and kidney proximal tubule;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer. Interacts with EPHB2; involved in endolymph production in the inner ear.
    Function:
    Forms a water-specific channel that provides the plasma membranes of red cells and kidney proximal tubules with high permeability to water, thereby permitting water to move in the direction of an osmotic gradient.
    Subcellular Location:
    Membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    269
    Sequence:
    50:
    MASEFKKKLF | WRAVVAEFLA | TTLFVFISIG | SALGFKYPVG | NNQTAVQDNV | 
    100:
    KVSLAFGLSI | ATLAQSVGHI | SGAHLNPAVT | LGLLLSCQIS | IFRALMYIIA | 
    150:
    QCVGAIVATA | ILSGITSSLT | GNSLGRNDLA | DGVNSGQGLG | IEIIGTLQLV | 
    200:
    LCVLATTDRR | RRDLGGSAPL | AIGLSVALGH | LLAIDYTGCG | INPARSFGSA | 
    250:
    VITHNFSNHW | IFWVGPFIGG | ALAVLIYDFI | LAPRSSDLTD | RVKVWTSGQV | 
    269:
    EEYDLDADDI | NSRVEMKPK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    SMR:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human AQP-1
    Cat.:
    E0579h
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    ELISA Kit for Human AQP-1
    Cat.:
    E0579m
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    MSDS:
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    Packing:
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    ELISA Kit for Human AQP-1
    Cat.:
    E0579r
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    ELISA Kit for Human AQP-1
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    E0579p
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    96T
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    ELISA Kit for Human AQP-1
    Cat.:
    E0579d
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human AQP-1
    Cat.:
    E0579b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AQP-1
    Cat.:
    U0579r
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AQP-1
    Cat.:
    U0579b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AQP-1
    Cat.:
    U0579h
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AQP-1
    Cat.:
    U0579d
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AQP-1
    Cat.:
    U0579p
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human AQP-1
    Cat.:
    U0579m
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    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human AQP-1
    Polyclonal Antibody for Human AQP-1
    Cat.:
    P0579Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AQP-1
    Polyclonal Antibody for Human AQP-1
    Cat.:
    P0579Rb-m
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human AQP-1
    Polyclonal Antibody for Human AQP-1
    Cat.:
    P0579Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human AQP-1
    Monoclonal Antibody for Human AQP-1
    Monoclonal Antibody for Human AQP-1
    Monoclonal Antibody for Human AQP-1
    Monoclonal Antibody for Human AQP-1
    Monoclonal Antibody for Human AQP-1
    Protein for Human AQP-1
    Protein for Human AQP-1
    Protein for Human AQP-1
    Protein for Human AQP-1
    Protein for Human AQP-1
    Protein for Human AQP-1

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation of the cDNA for erythrocyte integral membrane protein of 28 kilodaltons: member of an ancient channel family."
      Preston G.M. , Agre P.
      Proc. Natl. Acad. Sci. U.S.A.88:11110-11114(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
    2. 2.
      "The human aquaporin-CHIP gene. Structure, organization, and chromosomal localization."
      Moon C. , Preston G.M. , Griffin C.A. , Jabs E.W. , Agre P.
      J. Biol. Chem.268:15772-15778(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Characterization of the 3' UTR sequence encoded by the AQP-1 gene in human retinal pigment epithelium."
      Ruiz A.C. , Bok D.
      Biochim. Biophys. Acta1282:174-178(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Retinal pigment epithelium.
    4. 4.
      "The water channel gene in human uterus."
      Li X. , Yu H. , Koide S.S.
      Biochem. Mol. Biol. Int.32:371-377(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Uterus.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Mesangial cell.
    6. 6.
      SeattleSNPs variation discovery resource
      Submitted (2005-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS VAL-45 AND ASP-165
    7. 7.
      "Human protein factory for converting the transcriptome into an in vitro-expressed proteome."
      Goshima N. , Kawamura Y. , Fukumoto A. , Miura A. , Honma R. , Satoh R. , Wakamatsu A. , Yamamoto J. , Kimura K. , Nishikawa T. , Andoh T. , Iida Y. , Ishikawa K. , Ito E. , Kagawa N. , Kaminaga C. , Kanehori K. , Kawakami B. , more...
      Nat. Methods5:1011-1017(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    8. 8.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    10. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    11. 11.
      "Human chondrocytes in situ express aquaporin water channels: changes in AQP1 abundance in pathologies of articular cartilage."
      Trujillo E. , Gonzalez T. , Martin-Vasallo P. , Marples D. , Mobasheri A.
      Submitted (2002-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 5-269
      tissue: Articular cartilage.
    12. 12.
      "Erythrocyte Mr 28,000 transmembrane protein exists as a multisubunit oligomer similar to channel proteins."
      Smith B.L. , Agre P.
      J. Biol. Chem.266:6407-6415(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-36
    13. 13.
      "Appearance of water channels in Xenopus oocytes expressing red cell CHIP28 protein."
      Preston G.M. , Carroll T.P. , Guggino W.B. , Agre P.
      Science256:385-387(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "The mercury-sensitive residue at cysteine 189 in the CHIP28 water channel."
      Preston G.M. , Jung J.S. , Guggino W.B. , Agre P.
      J. Biol. Chem.268:17-20(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TARGET OF MERCURY INHIBITION
    15. 15.
      "Membrane topology of aquaporin CHIP. Analysis of functional epitope-scanning mutants by vectorial proteolysis."
      Preston G.M. , Jung J.S. , Guggino W.B. , Agre P.
      J. Biol. Chem.269:1668-1673(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TOPOLOGY
    16. 16.
      "Stomatin interacts with GLUT1/SLC2A1, band 3/SLC4A1, and aquaporin-1 in human erythrocyte membrane domains."
      Rungaldier S. , Oberwagner W. , Salzer U. , Csaszar E. , Prohaska R.
      Biochim. Biophys. Acta1828:956-966(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY;IDENTIFICATION IN A COMPLEX WITH STOM;SUBUNIT
    17. 17.
      "The three-dimensional structure of human erythrocyte aquaporin CHIP."
      Walz T. , Smith B.L. , Agre P. , Engel A.
      EMBO J.13:2985-2993(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY ELECTRON MICROSCOPY (1.6 ANGSTROMS)
    18. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY ELECTRON MICROSCOPY (6 ANGSTROMS)
    19. 19.
      "Structural determinants of water permeation through aquaporin-1."
      Murata K. , Mitsuoka K. , Hirai T. , Walz T. , Agre P. , Heymann J.B. , Engel A. , Fujiyoshi Y.
      Nature407:599-605(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY ELECTRON MICROSCOPY (3.8 ANGSTROMS)
    20. 20.
      "A refined structure of human aquaporin-1."
      de Groot B.L. , Engel A. , Grubmueller H.
      FEBS Lett.504:206-211(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY ELECTRON MICROSCOPY (3.54 ANGSTROMS)
    21. 21.
      "Visualization of a water-selective pore by electron crystallography in vitreous ice."
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