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Index > Protein center > ARAF(Gene name) > Human
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  • ARAF (Gene name),
  • Serine/threonine-protein kinase A-Raf (Protein name ),  ARAF_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ARAF(ARAF1;PKS;PKS2);
    Protein name:
    Serine/threonine-protein kinase A-Raf;
    Alternative:
    Proto-oncogene A-Raf-1;Proto-oncogene A-Raf;Proto-oncogene Pks;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with TH1L/NELFD.
    Function:
    Involved in the transduction of mitogenic signals from the cell membrane to the nucleus.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    606
    Sequence:
    50:
    MEPPRGPPAN | GAEPSRAVGT | VKVYLPNKQR | TVVTVRDGMS | VYDSLDKALK | 
    100:
    VRGLNQDCCV | VYRLIKGRKT | VTAWDTAIAP | LDGEELIVEV | LEDVPLTMHN | 
    150:
    FVRKTFFSLA | FCDFCLKFLF | HGFRCQTCGY | KFHQHCSSKV | PTVCVDMSTN | 
    200:
    RQQFYHSVQD | LSGGSRQHEA | PSNRPLNELL | TPQGPSPRTQ | HCDPEHFPFP | 
    250:
    APANAPLQRI | RSTSTPNVHM | VSTTAPMDSN | LIQLTGQSFS | TDAAGSRGGS | 
    300:
    DGTPRGSPSP | ASVSSGRKSP | HSKSPAEQRE | RKSLADDKKK | VKNLGYRDSG | 
    350:
    YYWEVPPSEV | QLLKRIGTGS | FGTVFRGRWH | GDVAVKVLKV | SQPTAEQAQA | 
    400:
    FKNEMQVLRK | TRHVNILLFM | GFMTRPGFAI | ITQWCEGSSL | YHHLHVADTR | 
    450:
    FDMVQLIDVA | RQTAQGMDYL | HAKNIIHRDL | KSNNIFLHEG | LTVKIGDFGL | 
    500:
    ATVKTRWSGA | QPLEQPSGSV | LWMAAEVIRM | QDPNPYSFQS | DVYAYGVVLY | 
    550:
    ELMTGSLPYS | HIGCRDQIIF | MVGRGYLSPD | LSKISSNCPK | AMRRLLSDCL | 
    600:
    KFQREERPLF | PQILATIELL | QRSLPKIERS | ASEPSLHRTQ | ADELPACLLS | 
    606:
    AARLVP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    UniGene:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serine/threonine-protein kinase A-Raf
    ELISA Kit for Human Serine/threonine-protein kinase A-Raf
    ELISA Kit for Human Serine/threonine-protein kinase A-Raf
    ELISA Kit for Human Serine/threonine-protein kinase A-Raf
    CLIA Kit for Human Serine/threonine-protein kinase A-Raf
    CLIA Kit for Human Serine/threonine-protein kinase A-Raf
    CLIA Kit for Human Serine/threonine-protein kinase A-Raf
    CLIA Kit for Human Serine/threonine-protein kinase A-Raf
    Polyclonal Antibody for Human Serine/threonine-protein kinase A-Raf
    Polyclonal Antibody for Human Serine/threonine-protein kinase A-Raf
    Polyclonal Antibody for Human Serine/threonine-protein kinase A-Raf
    Polyclonal Antibody for Human Serine/threonine-protein kinase A-Raf
    Monoclonal Antibody for Human Serine/threonine-protein kinase A-Raf
    Monoclonal Antibody for Human Serine/threonine-protein kinase A-Raf
    Monoclonal Antibody for Human Serine/threonine-protein kinase A-Raf
    Monoclonal Antibody for Human Serine/threonine-protein kinase A-Raf
    Protein for Human Serine/threonine-protein kinase A-Raf
    Protein for Human Serine/threonine-protein kinase A-Raf
    Protein for Human Serine/threonine-protein kinase A-Raf
    Protein for Human Serine/threonine-protein kinase A-Raf

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "The complete coding sequence of the human A-raf-1 oncogene and transforming activity of a human A-raf carrying retrovirus."
      Beck T.W. , Huleihel M. , Gunnell M. , Bonner T.I. , Rapp U.R.
      Nucleic Acids Res.15:595-609(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "The complete sequence and promoter activity of the human A-raf-1 gene (ARAF1)."
      Lee J.-E. , Beck T.W. , Brennscheidt U. , DeGennaro L.J. , Rapp U.R.
      Genomics20:43-55(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    3. 3.
      "DA-Raf1, a competent intrinsic dominant-negative antagonist of the Ras-ERK pathway, is required for myogenic differentiation."
      Yokoyama T. , Takano K. , Yoshida A. , Katada F. , Sun P. , Takenawa T. , Andoh T. , Endo T.
      J. Cell Biol.177:781-793(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION (ISOFORM 2);ALTERNATIVE SPLICING
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    5. 5.
      "Full-length cDNA libraries and normalization."
      Li W.B. , Gruber C. , Jessee J. , Polayes D.
      Submitted (2003-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Placenta.
    6. 6.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 292-589 (ISOFORM 1)
    9. 9.
      "Identification of TH1 as an interaction partner of A-Raf kinase."
      Yin X.L. , Chen S. , Gu J.X.
      Mol. Cell. Biochem.231:69-74(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NELFD
    10. 10.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-257;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 13.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-186;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-318;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    16. 16.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 18.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    19. 19.
      "PRR5L degradation promotes mTORC2-mediated PKC-delta phosphorylation and cell migration downstream of Galpha12."
      Gan X. , Wang J. , Wang C. , Sommer E. , Kozasa T. , Srinivasula S. , Alessi D. , Offermanns S. , Simon M.I. , Wu D.
      Nat. Cell Biol.14:686-696(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TOR SIGNALING
    20. 20.
      "Solution structure of the N-terminal RAS-binding domain (RBD) in human A-RAF kinase."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2005-07) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 19-91
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