Arap3 ELISA Kit for Mouse(Mus musculus) | EIAab.comArap3 ELISA Kit for Mouse(Mus musculus)

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Arap3 (Gene name),

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3 (Protein name ), ARAP3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Arap3(Centd3;Drag1;Kiaa4097);

Protein name:

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3;

Alternative:

Dual specificity Rho- and Arf-GTPase-activating protein 1;Centaurin-delta-3(Cnt-d3);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with INPPL1/SHIP2.

Function:

Phosphatidylinositol-3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol-3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Acts preferentially on ARF5 and on RHOA.

Subcellular Location:

Cytoplasm Cell membrane Peripheral membrane protein Cytoplasm cytoskeleton Cell projection lamellipodium Cell projection ruffle Cytoplasmic, and associated with F-actin-rich membrane ruffles and lamellipodia.

Protein Attributes:

Sequence length:

1538

Sequence:

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1538:

SQPTSPQAPS | PTSLPTPTPS | LPTQPPCTSN | PPSSQPLT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.247642

KEGG:

mmu:106952

Pfam:

PF01412

SMR:

Q8R5G7

String:

Q8R5G7

Uniprot:

Q8R5G7

FOR

ELISA Kit for Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

CLIA Kit for Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Polyclonal Antibody for Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Monoclonal Antibody for Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

Protein for Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"ARAP3 is transiently tyrosine phosphorylated in cells attaching to fibronectin and inhibits cell spreading in a RhoGAP-dependent manner."
Stacey T.T.I. , Nie Z. , Stewart A. , Najdovska M. , Hall N.E. , He H. , Randazzo P.A. , Lock P.
J. Cell Sci.117:6071-6084(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);FUNCTION;MUTAGENESIS OF ARG-938; TYR-1399 AND TYR-1404;PHOSPHORYLATION AT TYR-1399 AND TYR-1404;SUBCELLULAR LOCATION
strain: NIH Swiss.
tissue: Embryo.
2.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6.
tissue: Brain.
4.

"Prediction of the coding sequences of mouse homologues of KIAA gene. The complete nucleotide sequences of mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N. , Kikuno R.F. , Ohara R. , Inamoto S. , Nagase T. , Ohara O. , Koga H.
Submitted (2005-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 619-1538 (ISOFORM 3)
tissue: Brain.
5.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-1404;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.

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