Gene name:
Arid1a(Baf250;Baf250a;Osa1;Smarcf1);
Protein name:
AT-rich interactive domain-containing protein 1A(ARID domain-containing protein 1A);
Alternative:
BRG1-associated factor 250a(BAF250A);BRG1-associated factor 250(BAF250);SWI-like protein;Osa homolog 1;SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily F member 1;SWI/SNF complex protein p270;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Component of SWI/SNF chromatin remodeling complexes, in some of which it can be mutually exclusive with ARID1B/BAF250B. Component of the BAF (SWI/SNF-A) complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1/BAF190A, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Component of the SWI/SNF-B (PBAF) complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCD2/BAF60B, perhaps SMARCD3/BAF60C, SMARCC1/BAF155, SMARCC2/BAF170, PB1/BAF180, ARID2/BAF200, ARID1A/BAF250A or ARID1B/BAF250B and actin. Component of the SWI/SNF Brm complex, at least composed of SMARCA2/BRM/BAF190B, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, HDAC1, HDAC2, and RBAP4. Component of the SWI/SNF complex Brg1(I), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, BAF60 (one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C), SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A, SIN3A, and probably HDAC2 and RBAP4. Component of the SWI/SNF Brg1(II), at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A or ACTL6B/BAF53B, SMARCE1/BAF57, SMARCC1/BAF155, SMARCC2/BAF170, ARID1A/BAF250A and probably HDAC2 and RBAP4. Component of a SWI/SNF-like EPAFa complex, at least composed of SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, ACTL6A/BAF53A, SMARCE1/BAF57, SMARCD1/BAF60A, SMARCC1/BAF155, SMARCC2/BAF170, BAF250A and MLLT1/ENL. Component of a SWI/SNF-like complex containing ARID1A/BAF250A and ARID1B/BAF250B. Interacts through its C-terminus with SMARCA2/BRM/BAF190B and SMARCA4/BRG1/BAF190A. Component of the WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A, BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with SMARCC1/BAF155 (By similarity). Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, PHF10/BAF45A, ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin.
Function:
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Binds DNA non-specifically. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MAAQVAPAAA | SSLGNPPPPP | SELKKAEQQQ | REEAGGEAAA | AAAERGEMKA |
100:
AAGQESEGPA | VGPPQPLGKE | LQDGAESNGG | GGGGGAGSGG | GPGAEPDLKN |
150:
SNGNAGPRPA | LNNNLPEPPG | GGGGGGSSSS | DGVGAPPHSA | AAALPPPAYG |
200:
FGQAYGRSPS | AVAAAAAAVF | HQQHGGQQSP | GLAALQSGGG | GGLEPYAGPQ |
250:
QNSHDHGFPN | HQYNSYYPNR | SAYPPPPQAY | ALSSPRGGTP | GSGAAAAAGS |
300:
KPPPSSSASA | SSSSSSFAQQ | RFGAMGGGGP | SAAGGGTPQP | TATPTLNQLL |
350:
TSPSSARGYQ | GYPGGDYGGG | PQDGGAGKGP | ADMASQCWGA | AAAAAAAAAA |
400:
VSGGAQQRSH | HAPMSPGSSG | GGGQPLARTP | QSSSPMDQMG | KMRPQPYGGT |
450:
NPYSQQQGPP | SGPQQGHGYP | GQPYGSQTPQ | RYPMTMQGRA | QSAMGSLSYA |
500:
QQIPPYGQQG | PSAYGQQGQT | PYYNQQSPHP | QQQPPYAQQP | PSQTPHAQPS |
550:
YQQQPQTQQP | QLQSSQPPYS | QQPSQPPHQQ | SPTPYPSQQS | TTQQHPQSQP |
600:
PYSQPQAQSP | YQQQQPQQPA | SSSLSQQAAY | PQPQPQQSQQ | TAYSQQRFPP |
650:
PQELSQDSFG | SQASSAPSMT | SSKGGQEDMN | LSLQSRPSSL | PDLSGSIDDL |
700:
PMGTEGALSP | GVSTSGISSS | QGEQSNPAQS | PFSPHTSPHL | PGIRGPSPSP |
750:
VGSPASVAQS | RSGPLSPAAV | PGNQMPPRPP | SGQSDSIMHP | SMNQSSIAQD |
800:
RGYMQRNPQM | PQYTSPQPGS | ALSPRQPSGG | QMHSGVGSYQ | QNSMGSYGPQ |
850:
GSQYGPQGGY | PRQPNYNALP | NANYPNAGMA | GSMNPMGAGG | QMHGQPGIPP |
900:
YGTLPPGRMA | HASMGNRPYG | PNMANMPPQV | GSGMCPPPGG | MNRKTQESAV |
950:
AMHVAANSIQ | NRPPGYPNMN | QGGMMGTGPP | YGQGINSMAG | MINPQGPPYP |
1000:
MGGTMANNSA | GMAASPEMMG | LGDVKLTPAT | KMNNKADGTP | KTESKSKKSS |
1050:
SSTTTNEKIT | KLYELGGEPE | RKMWVDRYLA | FTEEKAMGMT | NLPAVGRKPL |
1100:
DLYRLYVSVK | EIGGLTQVNK | NKKWRELATN | LNVGTSSSAA | SSLKKQYIQC |
1150:
LYAFECKIER | GEDPPPDIFA | AADSKKSQPK | IQPPSPAGSG | SMQGPQTPQS |
1200:
TSSSMAEGGD | LKPPTPASTP | HSQIPPLPGM | SRSNSVGIQD | AFPDGSDPTF |
1250:
QKRNSMTPNP | GYQPSMNTSD | MMGRMSYEPN | KDPYGSMRKA | PGSDPFMSSG |
1300:
QGPNGGMGDP | YSRAAGPGLG | SVAMGPRQHY | PYGGPYDRVR | TEPGIGPEGN |
1350:
MGTGAPQPNL | MPSTPDSGMY | SPSRYPPQQQ | QQQQQQHDSY | GNQFSTQGTP |
1400:
SSSPFPSQQT | TMYQQQQQNY | KRPMDGTYGP | PAKRHEGEMY | SVPYSAGQGQ |
1450:
PQQQQLPAAQ | SQPASQPQAA | QPSPQQDVYN | QYSNAYPASA | TAATDRRPAG |
1500:
GPQNQFPFQF | GRDRVSAPPG | SSAQQNMPPQ | MMGGPIQASA | EVAQQGTMWQ |
1550:
GRNDMTYNYA | NRQNTGSATQ | GPAYHGVNRT | DEMLHTDQRA | NHEGPWPSHG |
1600:
TRQPPYGPSA | PVPPMTRPPP | SNYQPPPSMP | NHIPQVSSPA | PLPRPMENRT |
1650:
SPSKSPFLHS | GMKMQKAGPP | VPASHIAPTP | VQPPMIRRDI | TFPPGSVEAT |
1700:
QPVLKQRRRL | TMKDIGTPEA | WRVMMSLKSG | LLAESTWALD | TINILLYDDN |
1750:
SIMTFNLSQL | PGLLELLVEY | FRRCLIEIFG | ILKEYEVGDP | GQRTLLDPGR |
1800:
FTKVYSPAHT | EEEEEEHLDP | KLEEEEEEGV | GNDEEMAFLG | KDKPSSENNE |
1850:
EKLVSKFDKL | PVKIVQRNDP | FVVDCSDKLG | RVQEFDSGLL | HWRIGGGDTT |
1900:
EHIQTHFESK | IELLPSRPYV | PCPTPPRKHL | TTVEGTPGTT | EQEGPPPDGL |
1950:
PEKRITATMD | DMLSTRSSTL | TDEGAKSAEA | TKESSKFPFG | ISPAQSHRNI |
2000:
KILEDEPHSK | DETPLCTLLD | WQDSLAKRCV | CVSNTIRSLS | FVPGNDFEMS |
2050:
KHPGLLLILG | KLILLHHKHP | ERKQAPLTYE | KEEEQDQGVS | CDKVEWWWDC |
2100:
LEMLRENTLV | TLANISGQLD | LSPYPESICL | PVLDGLLHWA | VCPSAEAQDP |
2150:
FSTLGPNAVL | SPQRLVLETL | SKLSIQDNNV | DLILATPPFS | RLEKLYSTMV |
2200:
RFLSDRKNPV | CREMAVVLLA | NLAQGDSLAA | RAIAVQKGSI | GNLLGFLEDS |
2250:
LAATQFQQSQ | ASLLHMQNPP | FEPTSVDMMR | RAARALLALA | KVDENHSEFT |
2283:
LYESRLLDIS | VSPLMNSLVS | QVICDVLFLI | GQS
Vaild Sequence:
Related Databases
Uniprot:
