PYCARD ELISA Kit for Human(Homo sapiens) | EIAab.comPYCARD ELISA Kit for Human(Homo sapiens)

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PYCARD (Gene name),

Apoptosis-associated speck-like protein containing a CARD (Protein name ), ASC_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

PYCARD(ASC;CARD5;TMS1);

Protein name:

Apoptosis-associated speck-like protein containing a CARD(hASC);

Alternative:

PYD and CARD domain-containing protein;Caspase recruitment domain-containing protein 5;Target of methylation-induced silencing 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Forms complexes with other DAPIN domain-containing proteins. Interacts with CIAS1/PYPAF1 and PYDC1.

Function:

Promotes caspase-mediated apoptosis. This proapoptotic activity is mediated predominantly through the activation of caspase-9. May be a component of the inflammasome, a protein complex which also includes NALP2, CARD8 and CASP1 and whose function would be the activation of proinflammatory caspases.

Subcellular Location:

Cytoplasm Upstream of caspase activation, a redistribution from the cytoplasm to the aggregates occurs. These appear as hollow, perinuclear spherical, ball-like structures.

Protein Attributes:

Sequence length:

195

Sequence:

50:

100:

150:

195:

AEPTNPSKMR | KLFSFTPAWN | WTCKDLLLQA | LRESQSYLVE | DLERS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9ULZ3

KEGG:

hsa:29108

SMR:

Q9ULZ3

MIM:

606838

STRING:

9606.ENSP00000247470

Pfam:

PF00619

UniGene:

Hs.499094

Uniprot:

Q9ULZ3

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ELISA Kit for Human hASC

Cat.:

E3198m

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96T

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ELISA Kit for Human hASC

Cat.:

E3198h

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96T

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ELISA Kit for Human hASC

Cat.:

E3198b

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96T

CLIA Kit for Human hASC

Cat.:

U3198h

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96T

CLIA Kit for Human hASC

Cat.:

U3198m

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96T

CLIA Kit for Human hASC

Cat.:

U3198b

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96T

Polyclonal Antibody for Human hASC

Cat.:

P3198Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human hASC

Cat.:

P3198Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human hASC

Protein for Human hASC

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"ASC, a novel 22-kDa protein, aggregates during apoptosis of human promyelocytic leukemia HL-60 cells."
Masumoto J. , Taniguchi S. , Ayukawa K. , Sarvotham H. , Kishino T. , Niikawa N. , Hidaka E. , Katsuyama T. , Higuchi T. , Sagara J.
J. Biol. Chem.274:33835-33838(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Leukemia.
2.

"TMS1, a novel proapoptotic caspase recruitment domain protein, is a target of methylation-induced gene silencing in human breast cancers."
Conway K.E. , McConnell B.B. , Bowring C.E. , Donald C.D. , Warren S.T. , Vertino P.M.
Cancer Res.60:6236-6242(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORMS 1 AND 2)
tissue: Fibroblast.
3.

"A splice variant of ASC regulates IL-1beta release and aggregates differently from intact ASC."
Matsushita K. , Takeoka M. , Sagara J. , Itano N. , Kurose Y. , Nakamura A. , Taniguchi S.
Mediators Inflamm.2009:287387-287387(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2);FUNCTION (ISOFORM 2);MASS SPECTROMETRY (ISOFORM 2)
4.

"Pycard a PYD and CARD containing molecule."
Martinon F. , Hofmann K. , Tschopp J.
Submitted (2000-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
5.

"CARD5 protein is a CARD/PYRIN family member that is involved in apoptosis signal transduction."
Bertin J.
Submitted (2001-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Colon mucosa.
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 4-195 (ISOFORM 1)
tissue: Lymph.
tissue: Pancreas.
8.

"Activation of a caspase-9-mediated apoptotic pathway by subcellular redistribution of the novel caspase recruitment domain protein TMS1."
McConnell B.B. , Vertino P.M.
Cancer Res.60:6243-6247(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
9.

"Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis."
Geddes B.J. , Wang L. , Huang W.-J. , Lavellee M. , Manji G.A. , Brown M. , Jurman M. , Cao J. , Morgenstern J. , Merriam S. , Glucksmann M.A. , DiStefano P.S. , Bertin J.
Biochem. Biophys. Res. Commun.284:77-82(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRC4
10.

"Interaction between pyrin and the apoptotic speck protein (ASC) modulates ASC-induced apoptosis."
Richards N. , Schaner P. , Diaz A. , Stuckey J. , Shelden E. , Wadhwa A. , Gumucio D.L.
J. Biol. Chem.276:39320-39329(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MEFV
11.

"PYPAF1: a PYRIN-containing APAF1-like protein that assembles with ASC and activates NF-kB."
Manji G.A. , Wang L. , Geddes B.J. , Brown M. , Merriam S. , Al-Garawi A. , Mak S. , Lora J.M. , Briskin M. , Jurman M. , Cao J. , DiStefano P.S. , Bertin J.
J. Biol. Chem.277:11570-11575(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRP3;DOMAIN
12.

"The PYRIN-CARD protein ASC is an activating adaptor for caspase-1."
Srinivasula S.M. , Poyet J.L. , Razmara M. , Datta P. , Zhang Z. , Alnemri E.S.
J. Biol. Chem.277:21119-21122(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CASP1; NLRC4 AND CARD16
13.

"The PAAD/PYRIN-family protein ASC is a dual regulator of a conserved step in nuclear factor kappaB activation pathways."
Stehlik C. , Fiorentino L. , Dorfleutner A. , Bruey J.M. , Ariza E.M. , Sagara J. , Reed J.C.
J. Exp. Med.196:1605-1615(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CHUK AND IKBKB
14.

"The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta."
Martinon F. , Burns K. , Tschopp J.
Mol. Cell10:417-426(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN NLPR1 INFLAMMASOME
15.

"ASC is an activating adaptor for NF-kappa B and caspase-8-dependent apoptosis."
Masumoto J. , Dowds T.A. , Schaner P. , Chen F.F. , Ogura Y. , Li M. , Zhu L. , Katsuyama T. , Sagara J. , Taniguchi S. , Gumucio D.L. , Nunez G. , Inohara N.
Biochem. Biophys. Res. Commun.303:69-73(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;INTERACTION WITH CASP8;MUTAGENESIS OF LEU-12
16.

"The PAAD/PYRIN-only protein POP1/ASC2 is a modulator of ASC-mediated nuclear-factor-kappa B and pro-caspase-1 regulation."
Stehlik C. , Krajewska M. , Welsh K. , Krajewski S. , Godzik A. , Reed J.C.
Biochem. J.373:101-113(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PYDC1;PHOSPHORYLATION
17.

"Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation."
Stehlik C. , Lee S.H. , Dorfleutner A. , Stassinopoulos A. , Sagara J. , Reed J.C.
J. Immunol.171:6154-6163(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CASP1 AND RIPK2
18.

"NALP3 forms an IL-1beta-processing inflammasome with increased activity in Muckle-Wells autoinflammatory disorder."
Agostini L. , Martinon F. , Burns K. , McDermott M.F. , Hawkins P.N. , Tschopp J.
Immunity20:319-325(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NLRP2 AND NLRP3 INFLAMMASOMES;INTERACTION WITH NLRP2 AND NLRP3;SUBCELLULAR LOCATION
19.

"PYNOD, a novel Apaf-1/CED4-like protein is an inhibitor of ASC and caspase-1."
Wang Y. , Hasegawa M. , Imamura R. , Kinoshita T. , Kondo C. , Konaka K. , Suda T.
Int. Immunol.16:777-786(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRP10
20.

"Cryopyrin-induced interleukin 1beta secretion in monocytic cells: enhanced activity of disease-associated mutants and requirement for ASC."
Dowds T.A. , Masumoto J. , Zhu L. , Inohara N. , Nunez G.
J. Biol. Chem.279:21924-21928(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRP3
21.

"PAN1/NALP2/PYPAF2, an inducible inflammatory mediator that regulates NF-kappaB and caspase-1 activation in macrophages."
Bruey J.-M. , Bruey-Sedano N. , Newman R. , Chandler S. , Stehlik C. , Reed J.C.
J. Biol. Chem.279:51897-51907(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NLRP2;MUTAGENESIS OF GLU-13
22.

"ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway."
Ohtsuka T. , Ryu H. , Minamishima Y.A. , Macip S. , Sagara J. , Nakayama K.I. , Aaronson S.A. , Lee S.W.
Nat. Cell Biol.6:121-128(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS;SUBCELLULAR LOCATION;INTERACTION WITH BAX
23.

"Role of charged and hydrophobic residues in the oligomerization of the PYRIN domain of ASC."
Moriya M. , Taniguchi S. , Wu P. , Liepinsh E. , Otting G. , Sagara J.
Biochemistry44:575-583(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SELF-ASSOCIATION;MUTAGENESIS OF ILE-8; LEU-12; GLU-13; LEU-15; GLU-19; LEU-20; LYS-21; PHE-23; LEU-25; LYS-26; LEU-27; PRO-40; ARG-41; LEU-45; MET-47; ASP-48; LEU-52; LEU-56; GLU-62; GLU-67; LEU-68; VAL-72 AND MET-76
24.

"Cryopyrin and pyrin activate caspase-1, but not NF-kappaB, via ASC oligomerization."
Yu J.W. , Wu J. , Zhang Z. , Datta P. , Ibrahimi I. , Taniguchi S. , Sagara J. , Fernandes-Alnemri T. , Alnemri E.S.
Cell Death Differ.13:236-249(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ASSOCIATION WITH INFLAMMASOMES
25.

"ASC directs NF-kappaB activation by regulating receptor interacting protein-2 (RIP2) caspase-1 interactions."
Sarkar A. , Duncan M. , Hart J. , Hertlein E. , Guttridge D.C. , Wewers M.D.
J. Immunol.176:4979-4986(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CASP1
26.

"ASC mediates the induction of multiple cytokines by Porphyromonas gingivalis via caspase-1-dependent and -independent pathways."
Taxman D.J. , Zhang J. , Champagne C. , Bergstralh D.T. , Iocca H.A. , Lich J.D. , Ting J.P.
J. Immunol.177:4252-4256(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
27.

"The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation."
Fernandes-Alnemri T. , Wu J. , Yu J.W. , Datta P. , Miller B. , Jankowski W. , Rosenberg S. , Zhang J. , Alnemri E.S.
Cell Death Differ.14:1590-1604(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT
28.

"Reconstituted NALP1 inflammasome reveals two-step mechanism of caspase-1 activation."
Faustin B. , Lartigue L. , Bruey J.-M. , Luciano F. , Sergienko E. , Bailly-Maitre B. , Volkmann N. , Hanein D. , Rouiller I. , Reed J.C.
Mol. Cell25:713-724(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NLRP1 INFLAMMASOME
29.

"Mechanism of ASC-mediated apoptosis: bid-dependent apoptosis in type II cells."
Hasegawa M. , Kawase K. , Inohara N. , Imamura R. , Yeh W.C. , Kinoshita T. , Suda T.
Oncogene26:1748-1756(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS
30.

"Cellular pyrin domain-only protein 2 is a candidate regulator of inflammasome activation."
Dorfleutner A. , Bryan N.B. , Talbott S.J. , Funya K.N. , Rellick S.L. , Reed J.C. , Shi X. , Rojanasakul Y. , Flynn D.C. , Stehlik C.
Infect. Immun.75:1484-1492(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PYDC2
31.

"Pyrin-only protein 2 modulates NF-kappaB and disrupts ASC:CLR interactions."
Bedoya F. , Sandler L.L. , Harton J.A.
J. Immunol.178:3837-3845(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PYDC2
32.

"Mapping of POP1-binding site on pyrin domain of ASC."
Srimathi T. , Robbins S.L. , Dubas R.L. , Chang H. , Cheng H. , Roder H. , Park Y.C.
J. Biol. Chem.283:15390-15398(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PYDC1;MUTAGENESIS OF GLU-13; TYR-36 AND ASP-48
33.

"Activation of inflammasomes requires intracellular redistribution of the apoptotic speck-like protein containing a caspase recruitment domain."
Bryan N.B. , Dorfleutner A. , Rojanasakul Y. , Stehlik C.
J. Immunol.182:3173-3182(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
34.

"Mechanism and repertoire of ASC-mediated gene expression."
Hasegawa M. , Imamura R. , Motani K. , Nishiuchi T. , Matsumoto N. , Kinoshita T. , Suda T.
J. Immunol.182:7655-7662(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
35.

"AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA."
Fernandes-Alnemri T. , Yu J.W. , Datta P. , Wu J. , Alnemri E.S.
Nature458:509-513(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AIM2 INFLAMMASOME;INTERACTION WITH AIM2
36.

"AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC."
Hornung V. , Ablasser A. , Charrel-Dennis M. , Bauernfeind F. , Horvath G. , Caffrey D.R. , Latz E. , Fitzgerald K.A.
Nature458:514-518(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AIM2 INFLAMMASOME;INTERACTION WITH AIM2
37.

"Differential splicing of the apoptosis-associated speck like protein containing a caspase recruitment domain (ASC) regulates inflammasomes."
Bryan N.B. , Dorfleutner A. , Kramer S.J. , Yun C. , Rojanasakul Y. , Stehlik C.
J. Inflamm. (Lond.)7:23-23(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORMS 2 AND 3)
38.

"Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production."
Poeck H. , Bscheider M. , Gross O. , Finger K. , Roth S. , Rebsamen M. , Hannesschlager N. , Schlee M. , Rothenfusser S. , Barchet W. , Kato H. , Akira S. , Inoue S. , Endres S. , Peschel C. , Hartmann G. , Hornung V. , Ruland J.
Nat. Immunol.11:63-69(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDX58
39.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
40.

"IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection."
Kerur N. , Veettil M.V. , Sharma-Walia N. , Bottero V. , Sadagopan S. , Otageri P. , Chandran B.
Cell Host Microbe9:363-375(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IFI16
41.

"The NLR adaptor ASC/PYCARD regulates DUSP10, mitogen-activated protein kinase (MAPK), and chemokine induction independent of the inflammasome."
Taxman D.J. , Holley-Guthrie E.A. , Huang M.T. , Moore C.B. , Bergstralh D.T. , Allen I.C. , Lei Y. , Gris D. , Ting J.P.
J. Biol. Chem.286:19605-19616(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
42.

"Central and overlapping role of cathepsin B and inflammasome adaptor ASC in antigen presenting function of human dendritic cells."
Guo X. , Dhodapkar K.M.
Hum. Immunol.73:871-878(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
43.

"A role for mitochondria in NLRP3 inflammasome activation."
Zhou R. , Yazdi A.S. , Menu P. , Tschopp J.
Nature469:221-225(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
44.

"The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition."
Liepinsh E. , Barbals R. , Dahl E. , Sharipo A. , Staub E. , Otting G.
J. Mol. Biol.332:1155-1163(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 1-91;FUNCTION OF DAPIN DOMAIN
45.

"Structure and interdomain dynamics of apoptosis-associated speck-like protein containing a CARD (ASC)."
de Alba E.
J. Biol. Chem.284:32932-32941(2009) [PubMed] [Europe PMC] [Abstract]

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