ASPH ELISA Kit for Human(Homo sapiens) | EIAab.comASPH ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ASPH(Gene name) > Human

ASPH (Gene name),

Aspartyl/asparaginyl beta-hydroxylase (Protein name ), ASPH_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ASPH;

Protein name:

Aspartyl/asparaginyl beta-hydroxylase;

Alternative:

Peptide-aspartate beta-dioxygenase;Aspartate beta-hydroxylase(ASP beta-hydroxylase);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Monomer.

Function:

Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.

Subcellular Location:

Isoform 1 Endoplasmic reticulum membrane Single-pass type II membrane protein

Protein Attributes:

Sequence length:

758

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

758:

QRRSLPAI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q12797

KEGG:

hsa:444

STRING:

9606.ENSP00000368767

Pfam:

PF05279

MIM:

600582

SMR:

Q12797

UniGene:

Hs.332422

Uniprot:

Q12797

FOR

ELISA Kit for Human Aspartyl/asparaginyl beta-hydroxylase

Cat.:

E12398h

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96T

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ELISA Kit for Human Aspartyl/asparaginyl beta-hydroxylase

MSDS:

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ELISA Kit for Human Aspartyl/asparaginyl beta-hydroxylase

Cat.:

E12398m

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Packing:

96T

CLIA Kit for Human Aspartyl/asparaginyl beta-hydroxylase

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CLIA Kit for Human Aspartyl/asparaginyl beta-hydroxylase

Cat.:

U12398m

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MSDS:

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Packing:

96T

CLIA Kit for Human Aspartyl/asparaginyl beta-hydroxylase

Cat.:

U12398h

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human Aspartyl/asparaginyl beta-hydroxylase

Cat.:

P12398Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Aspartyl/asparaginyl beta-hydroxylase

Monoclonal Antibody for Human Aspartyl/asparaginyl beta-hydroxylase

Protein for Human Aspartyl/asparaginyl beta-hydroxylase

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase."
Korioth F. , Gieffers C. , Frey J.
Gene150:395-399(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.

"Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma."
Lavaissiere L. , Jia S. , Nishiyama M. , de la Monte S. , Stern A.M. , Wands J.R. , Friedman P.A.
J. Clin. Invest.98:1313-1323(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.

"cDNA cloning and characterization of human cardiac junctin."
Lim K.Y. , Hong C.-S. , Kim D.H.
Gene255:35-42(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4)
tissue: Heart.
4.

"Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin."
Dinchuk J.E. , Henderson N.L. , Burn T.C. , Huber R. , Ho S.P. , Link J. , O'Neil K.T. , Focht R.J. , Scully M.S. , Hollis J.M. , Hollis G.F. , Friedman P.A.
J. Biol. Chem.275:39543-39554(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Liver.
5.

"Molecular cloning, expression, functional characterization, chromosomal localization, and gene structure of junctate, a novel integral calcium binding protein of sarco(endo)plasmic reticulum membrane."
Treves S. , Feriotto G. , Moccagatta L. , Gambari R. , Zorzato F.
J. Biol. Chem.275:39555-39568(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8);CALCIUM-BINDING;ALTERNATIVE SPLICING;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
tissue: Muscle.
6.

"Molecular cloning of junctin from human and developing rabbit heart."
Wetzel G.T. , Ding S. , Chen F.
Mol. Genet. Metab.69:252-258(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
tissue: Heart.
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 9 AND 10)
tissue: Hippocampus.
tissue: Trachea.
8.

"DNA sequence and analysis of human chromosome 8."
Nusbaum C. , Mikkelsen T.S. , Zody M.C. , Asakawa S. , Taudien S. , Garber M. , Kodira C.D. , Schueler M.G. , Shimizu A. , Whittaker C.A. , Chang J.L. , Cuomo C.A. , Dewar K. , FitzGerald M.G. , Yang X. , Allen N.R. , Anderson S. , Asakawa T. , more...
Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7)
tissue: Brain.
tissue: Pancreatic carcinoma.
11.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)."
Srikanth S. , Jew M. , Kim K.D. , Yee M.K. , Abramson J. , Gwack Y.
Proc. Natl. Acad. Sci. U.S.A.109:8682-8687(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CALCIUM-BINDING DOMAIN;INTERACTION WITH ORAI1 AND STIM1 (ISOFORM 8);MUTAGENESIS OF 91-ASP--ASP-93;SUBCELLULAR LOCATION
14.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-452 (ISOFORM 1);GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64 (ISOFORM 3)
tissue: Liver.
15.

"Calsequestrin mutant D307H exhibits depressed binding to its protein targets and a depressed response to calcium."
Houle T.D. , Ram M.L. , Cala S.E.
Cardiovasc. Res.64:227-233(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CASQ2 (ISOFORM 4);SUBCELLULAR LOCATION
16.

"Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia."
Dinchuk J.E. , Focht R.J. , Kelley J.A. , Henderson N.L. , Zolotarjova N.I. , Wynn R. , Neff N.T. , Link J. , Huber R.M. , Burn T.C. , Rupar M.J. , Cunningham M.R. , Selling B.H. , Ma J. , Stern A.A. , Hollis G.F. , Stein R.B. , Friedman P.A.
J. Biol. Chem.277:12970-12977(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 1);CATALYTIC ACTIVITY
17.

"Crystal structure of human aspartate beta-hydroxylase isoform A."
Structural genomics consortium (SGC)
Submitted (2011-05) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 562-758 IN COMPLEX WITH N-OXALYOLGLYCINE AND ZINC IONS;DISULFIDE BOND
18.

"Mutations in ASPH cause facial dysmorphism, lens dislocation, anterior-segment abnormalities, and spontaneous filtering blebs, or Traboulsi syndrome."
Patel N. , Khan A.O. , Mansour A. , Mohamed J.Y. , Al-Assiri A. , Haddad R. , Jia X. , Xiong Y. , Megarbane A. , Traboulsi E.I. , Alkuraya F.S.
Am. J. Hum. Genet.94:755-759(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN FDLAB;VARIANT FDLAB TRP-735

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