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Index > Protein center > ASPH(Gene name) > Human
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  • ASPH (Gene name),
  • Aspartyl/asparaginyl beta-hydroxylase (Protein name ),  ASPH_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ASPH;
    Protein name:
    Aspartyl/asparaginyl beta-hydroxylase;
    Alternative:
    Aspartate beta-hydroxylase(ASP beta-hydroxylase);Peptide-aspartate beta-dioxygenase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.
    Subcellular Location:
    Isoform 1 Endoplasmic reticulum membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    758
    Sequence:
    50:
    MAQRKNAKSS | GNSSSSGSGS | GSTSAGSSSP | GARRETKHGG | HKNGRKGGLS | 
    100:
    GTSFFTWFMV | IALLGVWTSV | AVVWFDLVDY | EEVLGKLGIY | DADGDGDFDV | 
    150:
    DDAKVLLGLK | ERSTSEPAVP | PEEAEPHTEP | EEQVPVEAEP | QNIEDEAKEQ | 
    200:
    IQSLLHEMVH | AEHVEGEDLQ | QEDGPTGEPQ | QEDDEFLMAT | DVDDRFETLE | 
    250:
    PEVSHEETEH | SYHVEETVSQ | DCNQDMEEMM | SEQENPDSSE | PVVEDERLHH | 
    300:
    DTDDVTYQVY | EEQAVYEPLE | NEGIEITEVT | APPEDNPVED | SQVIVEEVSI | 
    350:
    FPVEEQQEVP | PETNRKTDDP | EQKAKVKKKK | PKLLNKFDKT | IKAELDAAEK | 
    400:
    LRKRGKIEEA | VNAFKELVRK | YPQSPRARYG | KAQCEDDLAE | KRRSNEVLRG | 
    450:
    AIETYQEVAS | LPDVPADLLK | LSLKRRSDRQ | QFLGHMRGSL | LTLQRLVQLF | 
    500:
    PNDTSLKNDL | GVGYLLIGDN | DNAKKVYEEV | LSVTPNDGFA | KVHYGFILKA | 
    550:
    QNKIAESIPY | LKEGIESGDP | GTDDGRFYFH | LGDAMQRVGN | KEAYKWYELG | 
    600:
    HKRGHFASVW | QRSLYNVNGL | KAQPWWTPKE | TGYTELVKSL | ERNWKLIRDE | 
    650:
    GLAVMDKAKG | LFLPEDENLR | EKGDWSQFTL | WQQGRRNENA | CKGAPKTCTL | 
    700:
    LEKFPETTGC | RRGQIKYSIM | HPGTHVWPHT | GPTNCRLRMH | LGLVIPKEGC | 
    750:
    KIRCANETKT | WEEGKVLIFD | DSFEHEVWQD | ASSFRLIFIV | DVWHPELTPQ | 
    758:
    QRRSLPAI
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    Pfam:
    SMR:
    String:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    E12398h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Aspartyl/asparaginyl beta-hydroxylase
    MSDS:
    Please sign in first.
    ELISA Kit for Human Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    E12398m
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Aspartyl/asparaginyl beta-hydroxylase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    U12398h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    U12398m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Aspartyl/asparaginyl beta-hydroxylase
    Polyclonal Antibody for Human Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    P12398Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Aspartyl/asparaginyl beta-hydroxylase
    Monoclonal Antibody for Human Aspartyl/asparaginyl beta-hydroxylase
    Monoclonal Antibody for Human Aspartyl/asparaginyl beta-hydroxylase
    Monoclonal Antibody for Human Aspartyl/asparaginyl beta-hydroxylase
    Protein for Human Aspartyl/asparaginyl beta-hydroxylase
    Protein for Human Aspartyl/asparaginyl beta-hydroxylase
    Protein for Human Aspartyl/asparaginyl beta-hydroxylase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Cloning and characterization of the human gene encoding aspartyl beta-hydroxylase."
      Korioth F. , Gieffers C. , Frey J.
      Gene150:395-399(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Overexpression of human aspartyl(asparaginyl)beta-hydroxylase in hepatocellular carcinoma and cholangiocarcinoma."
      Lavaissiere L. , Jia S. , Nishiyama M. , de la Monte S. , Stern A.M. , Wands J.R. , Friedman P.A.
      J. Clin. Invest.98:1313-1323(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "cDNA cloning and characterization of human cardiac junctin."
      Lim K.Y. , Hong C.-S. , Kim D.H.
      Gene255:35-42(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4)
      tissue: Heart.
    4. 4.
      "Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin."
      Dinchuk J.E. , Henderson N.L. , Burn T.C. , Huber R. , Ho S.P. , Link J. , O'Neil K.T. , Focht R.J. , Scully M.S. , Hollis J.M. , Hollis G.F. , Friedman P.A.
      J. Biol. Chem.275:39543-39554(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Liver.
    5. 5.
      "Molecular cloning, expression, functional characterization, chromosomal localization, and gene structure of junctate, a novel integral calcium binding protein of sarco(endo)plasmic reticulum membrane."
      Treves S. , Feriotto G. , Moccagatta L. , Gambari R. , Zorzato F.
      J. Biol. Chem.275:39555-39568(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 8);CALCIUM-BINDING;ALTERNATIVE SPLICING;TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      tissue: Muscle.
    6. 6.
      "Molecular cloning of junctin from human and developing rabbit heart."
      Wetzel G.T. , Ding S. , Chen F.
      Mol. Genet. Metab.69:252-258(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
      tissue: Heart.
    7. 7.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 9 AND 10)
      tissue: Hippocampus.
      tissue: Trachea.
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    9. 10.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 5; 6 AND 7)
      tissue: Brain.
      tissue: Pancreatic carcinoma.
    10. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 13.
      "Junctate is a Ca2+-sensing structural component of Orai1 and stromal interaction molecule 1 (STIM1)."
      Srikanth S. , Jew M. , Kim K.D. , Yee M.K. , Abramson J. , Gwack Y.
      Proc. Natl. Acad. Sci. U.S.A.109:8682-8687(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CALCIUM-BINDING DOMAIN;INTERACTION WITH ORAI1 AND STIM1 (ISOFORM 8);MUTAGENESIS OF 91-ASP--ASP-93;SUBCELLULAR LOCATION
    13. 14.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-452 (ISOFORM 1);GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-64 (ISOFORM 3)
      tissue: Liver.
    14. 15.
      "Calsequestrin mutant D307H exhibits depressed binding to its protein targets and a depressed response to calcium."
      Houle T.D. , Ram M.L. , Cala S.E.
      Cardiovasc. Res.64:227-233(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CASQ2 (ISOFORM 4);SUBCELLULAR LOCATION
    15. 16.
      "Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia."
      Dinchuk J.E. , Focht R.J. , Kelley J.A. , Henderson N.L. , Zolotarjova N.I. , Wynn R. , Neff N.T. , Link J. , Huber R.M. , Burn T.C. , Rupar M.J. , Cunningham M.R. , Selling B.H. , Ma J. , Stern A.A. , Hollis G.F. , Stein R.B. , Friedman P.A.
      J. Biol. Chem.277:12970-12977(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION (ISOFORM 1);CATALYTIC ACTIVITY
    16. 17.
      "Crystal structure of human aspartate beta-hydroxylase isoform A."
      Structural genomics consortium (SGC)
      Submitted (2011-05) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.05 ANGSTROMS) OF 562-758 IN COMPLEX WITH N-OXALYOLGLYCINE AND ZINC IONS;DISULFIDE BOND
    17. 18.
      "Mutations in ASPH cause facial dysmorphism, lens dislocation, anterior-segment abnormalities, and spontaneous filtering blebs, or Traboulsi syndrome."
      Patel N. , Khan A.O. , Mansour A. , Mohamed J.Y. , Al-Assiri A. , Haddad R. , Jia X. , Xiong Y. , Megarbane A. , Traboulsi E.I. , Alkuraya F.S.
      Am. J. Hum. Genet.94:755-759(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN FDLAB;VARIANT FDLAB TRP-735
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