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Index > Protein center > Asph(Gene name) > Mouse
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  • Asph (Gene name),
  • Aspartyl/asparaginyl beta-hydroxylase (Protein name ),  ASPH_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Asph;
    Protein name:
    Aspartyl/asparaginyl beta-hydroxylase;
    Alternative:
    Peptide-aspartate beta-dioxygenase;Aspartate beta-hydroxylase(ASP beta-hydroxylase);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer.
    Function:
    Specifically hydroxylates an Asp or Asn residue in certain epidermal growth factor-like (EGF) domains of a number of proteins.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type II membrane protein
    Protein Attributes:
    Sequence length:
    741
    Sequence:
    50:
    MAPRKNAKGG | GGNSSSSGSG | SGSGSGSPST | GSSGSSSSPG | ARREAKHGGH | 
    100:
    KNGRRGGISG | GSFFTWFMVI | ALLGVWTSVA | VVWFDLVDYE | EVLGKLGVYD | 
    150:
    ADGDGDFDVD | DAKVLLGLKE | RSPSERTFPP | EEEAETHAEL | EEQAPEGADI | 
    200:
    QNVEDEVKEQ | IQSLLQESVH | TDHDLEADGL | AGEPQPEVED | FLTVTDSDDR | 
    250:
    FEDLEPGTVH | EEIEDTYHVE | DTASQNHPND | MEEMTNEQEN | SDPSEAVTDA | 
    300:
    GVLLPHAEEV | RHQDYDEPVY | EPSEHEGVAI | SDNTIDDSSI | ISEEINVASV | 
    350:
    EEQQDTPPVK | KKKPKLLNKF | DKTIKAELDA | AEKLRKRGKI | EEAVNAFEEL | 
    400:
    VRKYPQSPRA | RYGKAQCEDD | LAEKQRSNEV | LRRAIETYQE | AADLPDAPTD | 
    450:
    LVKLSLKRRS | ERQQFLGHMR | GSLLTLQRLV | QLFPSDTTLK | NDLGVGYLLL | 
    500:
    GDNDSAKKVY | EEVLNVTPND | GFAKVHYGFI | LKAQNKISES | IPYLKEGIES | 
    550:
    GDPGTDDGRF | YFHLGDAMQR | VGNKEAYKWY | ELGHKRGHFA | SVWQRSLYNV | 
    600:
    NGLKAQPWWT | PRETGYTELV | KSLERNWKLI | RDEGLMVMDK | AKGLFLPEDE | 
    650:
    NLREKGDWSQ | FTLWQQGRKN | ENACKGAPKT | CALLEKFSET | TGCRRGQIKY | 
    700:
    SIMHPGTHVW | PHTGPTNCRL | RMHLGLVIPK | EGCKIRCANE | TRTWEEGKVL | 
    741:
    IFDDSFEHEV | WQDASSFRLI | FIVDVWHPEL | TPQQRRSLPA | I
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    UniGene:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    E12398h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Mouse Aspartyl/asparaginyl beta-hydroxylase
    MSDS:
    Please sign in first.
    ELISA Kit for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    E12398m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Aspartyl/asparaginyl beta-hydroxylase
    MSDS:
    Please sign in first.
    CLIA Kit for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    U12398m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    U12398h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Cat.:
    P12398Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Polyclonal Antibody for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Monoclonal Antibody for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Monoclonal Antibody for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Monoclonal Antibody for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Protein for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Protein for Mouse Aspartyl/asparaginyl beta-hydroxylase
    Protein for Mouse Aspartyl/asparaginyl beta-hydroxylase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Purification, primary structure, and immunological characterization of the 26-kDa calsequestrin binding protein (junctin) from cardiac junctional sarcoplasmic reticulum."
      Jones L.R. , Zhang L. , Sanborn K. , Jorgensen A.O. , Kelley J.
      J. Biol. Chem.270:30787-30796(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY;SUBCELLULAR LOCATION
      tissue: Heart muscle.
    2. 2.
      "Aspartyl beta -hydroxylase (Asph) and an evolutionarily conserved isoform of Asph missing the catalytic domain share exons with junctin."
      Dinchuk J.E. , Henderson N.L. , Burn T.C. , Huber R. , Ho S.P. , Link J. , O'Neil K.T. , Focht R.J. , Scully M.S. , Hollis J.M. , Hollis G.F. , Friedman P.A.
      J. Biol. Chem.275:39543-39554(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
      strain: BALB/c.
      tissue: Liver.
    3. 3.
      "Mouse junctin-1 mRNA."
      Hong C. , Kim D.H.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: BALB/c.
      tissue: Heart.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
    6. 6.
      "Absence of post-translational aspartyl beta-hydroxylation of epidermal growth factor domains in mice leads to developmental defects and an increased incidence of intestinal neoplasia."
      Dinchuk J.E. , Focht R.J. , Kelley J.A. , Henderson N.L. , Zolotarjova N.I. , Wynn R. , Neff N.T. , Link J. , Huber R.M. , Burn T.C. , Rupar M.J. , Cunningham M.R. , Selling B.H. , Ma J. , Stern A.A. , Hollis G.F. , Stein R.B. , Friedman P.A.
      J. Biol. Chem.277:12970-12977(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;CATALYTIC ACTIVITY;TISSUE SPECIFICITY
    7. 7.
      "Triadin/junctin double null mouse reveals a differential role for triadin and junctin in anchoring CASQ to the jSR and regulating Ca(2+) homeostasis."
      Boncompagni S. , Thomas M. , Lopez J.R. , Allen P.D. , Yuan Q. , Kranias E.G. , Franzini-Armstrong C. , Perez C.F.
      PLoS ONE7:E39962-E39962(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    8. 8.
      "Mutations in ASPH cause facial dysmorphism, lens dislocation, anterior-segment abnormalities, and spontaneous filtering blebs, or Traboulsi syndrome."
      Patel N. , Khan A.O. , Mansour A. , Mohamed J.Y. , Al-Assiri A. , Haddad R. , Jia X. , Xiong Y. , Megarbane A. , Traboulsi E.I. , Alkuraya F.S.
      Am. J. Hum. Genet.94:755-759(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE
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